Researchers

Details

    Hélène Decaluwe , M.D. , Ph.D. , FRCPC

    helene.decaluwe@umontreal.ca
    Hélène Decaluwe
    Research Axis
    Viral and Immune Disorders and Cancers
    Research Theme
    Viral Diseases
    Address
    CHUSJ

    Phone
    514 345-4713

    Fax
    514 345-4897

    Title

    • Assistant Clinical Professor, Allergy-Immunology-Rheumatology Unit, Department of Pediatrics, University of Montreal.
    • Clinician Scientist, CHU Sainte-Justine Research Center.

    Education

    • PhD (Immunology), Pasteur Institute, Université Pierre et Marie Curie (UPMC), Paris, 2006-2010.
    • Master’s (Immunology), Faculty of Medicine, Necker Hospital for Sick Children, UPMC, Paris, 2004-2005.
    • Fellowship in Pediatric Immunology and Rheumatology, Necker Hospital for Sick Children, Paris, 2003-2005.
    • Specialized Studies Diploma in Pediatrics, University of Montreal, 1999-2003.
    • MD, McGill University, 1994-1999.

    Research Interests

    The ability to develop and maintain a population of memory cells after an infection or vaccination is the hallmark of adaptive responses and the basis of preventive vaccination against infectious pathogens. Understanding the mechanisms implicated in the differentiation of CD8+ T -lymphocytes is therefore essential for improving immunological memory after vaccination and developing novel cell-based therapies for the treatment of chronic viral infections and cancer. For this reason, our research interests focus, on the one hand, on the study of cell factors that are essential for eliminating a viral pathogen or a tumoral antigen and, on the other hand, on generating and maintaining antigen-specific memory CD8+ T -lymphocytes. By using transgenic mice, we are concentrating our efforts on the role of common gamma-chain dependent cytokines in the differentiation and generation of memory CD8+ T -lymphocytes after an viral infection or vaccination. We are also interested in the cytotoxic mechanisms that are essential for the effective elimination of viral or tumoral antigens, and on the development of T cell exhaustion in these contexts. Finally, we are interested in the kinetics of the reconstitution and function of CD8+ T -lymphocytes after bone marrow transplant.

    Awards and Distinctions

    • Clinical Research Scholar Junior 1 Award, Fonds de Recherche en Santé du Québec (FRSQ), 2012-2016
    • Canadian Child Health Clinician Scientist Career Development Award (CCHCSP), 2011-2015
    • Cole Foundation Transition Award, 2011-2014
    • Research Award, Canadian Louis Pasteur Foundation, 2008-2010
    • Doctorate Award, Fonds de Recherche en Santé du Québec (FRSQ), 2008-2009
    • Canadian Institutes of Health Research (CIHR) Industry Partnered Award, 2006-2008
    • Junior Research Fellowship Award, Association de Recherche sur le Cancer, 2006

Publications

Samuels ME, Majewski J, Aljazaeri A, Fernandez I, Casals F, Patey N, Decaluwé H, Gosselin I, Haddad E, Hodgkinson A, Idaghdour Y, Marchand V, Michaud JL, Rodrigue MA, Desjardins S, Dubois S, Le Deist F, Awadalla P, Raymond V, Maranda B,
Exome sequencing identifies mutations in the gene TTC7A in French-Canadian cases with hereditary multiple intestinal atresia
J Med Genet 2013 50(5): 324-329.

Perreault S, Bernard G, Lortie A, Le Deist F, Decaluwé H,
Ataxia-telangiectasia presenting with a novel immunodeficience
Pediatr Neurol 2012 46(5): 322-324.

Bader-Meunier B, Decaluwé H, Barnerias C, Gherardi R, Quartier P, Faye A, Guigonis V, Pagnier A, Brochard K, Sibilia J, Gottenberg JE, Bodemer C, Club Rhumatismes et Inflammation,
Safety and efficacy of rituximab in severe juvenile dermatomyositis: results from 9 patients from the French Autoimmunity and Rituximab registry
J Rheumatol 2011 38(7): 1436-1440.

Decaluwé H, Taillardet M, Corcuff E, Munitic I, Law HK, Rocha B, Rivière Y, Di Santo JP,
Gamma(c) deficiency precludes CD8+ T cell memory despite formation of potent T cell effectors
Proc Natl Acad Sci USA 2010 107(20): 9311-9116.

Munitic I, Decaluwé H, Evaristo C, Lemos S, Wlodarczyk M, Worth A, Le Bon A, Selin LK, Rivière Y, Di Santo JP, Borrow P, Rocha B,
Epitope specificity and relative clonal abundance do not affect CD8 differentiation patterns during lymphocytic choriomeningitis virus infection
J Virol 2009 83(22): 11795-11807.

Neven B, Leroy S, Decaluwé H, Le Deist F, Picard C, Moshous D, Mahlaoui N, Debre M, Casanova JL, Dal Cortivo L, Madec Y, Hacein-Bey-Abina S, de Saint Basile G, de Villartay JP, Blanche S, Cavazzana-Calvo M, Fischer A,
Long-term outcome after hematopoietic stem cell transplantation of a single-center cohort of 90 patients with severe combined immunodeficiency
Blood 2009 113(17): 4114-4124.

Rottman M, Soudais C, Vogt G, Renia L, Emile JF, Decaluwé H, Gaillard JL, Casanova JL,
IFN-gamma mediates the rejection of haematopoietic stem cells in IFN-gammaR1-deficient hosts
PLOS Medicine 2008 5(1): e26.

Masse GX, Corcuff E, Decaluwé H, Bommhardt U, Lantz O, Buer J, Di Santo JP,
Gamma(c) cytokines provide multiple homeostatic signals to naive CD4(+) T cells
Eur J Immunol 2007 37(9): 2606-1616.

 
 
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Edited by Olivier Cozette
Updated on 10/1/2014
Created on 9/18/2014
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Researchers