Viral and Immune Disorders and Cancers
Assistant Clinical Professor, Allergy-Immunology-Rheumatology Unit, Department of Pediatrics, University of Montreal.
Clinician Scientist, CHU Sainte-Justine Research Center.
PhD (Immunology), Pasteur Institute, Université Pierre et Marie Curie (UPMC), Paris, 2006-2010.
Master’s (Immunology), Faculty of Medicine, Necker Hospital for Sick Children, UPMC, Paris, 2004-2005.
Fellowship in Pediatric Immunology and Rheumatology, Necker Hospital for Sick Children, Paris, 2003-2005.
Specialized Studies Diploma in Pediatrics, University of Montreal, 1999-2003.
MD, McGill University, 1994-1999.
The ability to develop and maintain a population of memory cells after an infection or vaccination is the hallmark of adaptive responses and the basis of preventive vaccination against infectious pathogens. Understanding the mechanisms implicated in the differentiation of CD8+ T -lymphocytes is therefore essential for improving immunological memory after vaccination and developing novel cell-based therapies for the treatment of chronic viral infections and cancer. For this reason, our research interests focus, on the one hand, on the study of cell factors that are essential for eliminating a viral pathogen or a tumoral antigen and, on the other hand, on generating and maintaining antigen-specific memory CD8+ T -lymphocytes. By using transgenic mice, we are concentrating our efforts on the role of common gamma-chain dependent cytokines in the differentiation and generation of memory CD8+ T -lymphocytes after an viral infection or vaccination. We are also interested in the cytotoxic mechanisms that are essential for the effective elimination of viral or tumoral antigens, and on the development of T cell exhaustion in these contexts. Finally, we are interested in the kinetics of the reconstitution and function of CD8+ T -lymphocytes after bone marrow transplant.
Awards and Distinctions
Clinical Research Scholar Junior 1 Award, Fonds de Recherche en Santé du Québec (FRSQ), 2012-2016
Canadian Child Health Clinician Scientist Career Development Award (CCHCSP), 2011-2015
Cole Foundation Transition Award, 2011-2014
Research Award, Canadian Louis Pasteur Foundation, 2008-2010
Doctorate Award, Fonds de Recherche en Santé du Québec (FRSQ), 2008-2009
Canadian Institutes of Health Research (CIHR) Industry Partnered Award, 2006-2008
Junior Research Fellowship Award, Association de Recherche sur le Cancer, 2006
Samuels ME, Majewski J, Aljazaeri A, Fernandez I, Casals F, Patey N, Decaluwé H, Gosselin I, Haddad E, Hodgkinson A, Idaghdour Y, Marchand V, Michaud JL, Rodrigue MA, Desjardins S, Dubois S, Le Deist F, Awadalla P, Raymond V, Maranda B,
Exome sequencing identifies mutations in the gene TTC7A in French-Canadian cases with hereditary multiple intestinal atresia
J Med Genet
Perreault S, Bernard G, Lortie A, Le Deist F, Decaluwé H,
Ataxia-telangiectasia presenting with a novel immunodeficience
Bader-Meunier B, Decaluwé H, Barnerias C, Gherardi R, Quartier P, Faye A, Guigonis V, Pagnier A, Brochard K, Sibilia J, Gottenberg JE, Bodemer C, Club Rhumatismes et Inflammation,
Safety and efficacy of rituximab in severe juvenile dermatomyositis: results from 9 patients from the French Autoimmunity and Rituximab registry
Decaluwé H, Taillardet M, Corcuff E, Munitic I, Law HK, Rocha B, Rivière Y, Di Santo JP,
Gamma(c) deficiency precludes CD8+ T cell memory despite formation of potent T cell effectors
Proc Natl Acad Sci USA
Munitic I, Decaluwé H, Evaristo C, Lemos S, Wlodarczyk M, Worth A, Le Bon A, Selin LK, Rivière Y, Di Santo JP, Borrow P, Rocha B,
Epitope specificity and relative clonal abundance do not affect CD8 differentiation patterns during lymphocytic choriomeningitis virus infection
Neven B, Leroy S, Decaluwé H, Le Deist F, Picard C, Moshous D, Mahlaoui N, Debre M, Casanova JL, Dal Cortivo L, Madec Y, Hacein-Bey-Abina S, de Saint Basile G, de Villartay JP, Blanche S, Cavazzana-Calvo M, Fischer A,
Long-term outcome after hematopoietic stem cell transplantation of a single-center cohort of 90 patients with severe combined immunodeficiency
Rottman M, Soudais C, Vogt G, Renia L, Emile JF, Decaluwé H, Gaillard JL, Casanova JL,
IFN-gamma mediates the rejection of haematopoietic stem cells in IFN-gammaR1-deficient hosts
Masse GX, Corcuff E, Decaluwé H, Bommhardt U, Lantz O, Buer J, Di Santo JP,
Gamma(c) cytokines provide multiple homeostatic signals to naive CD4(+) T cells
Eur J Immunol