Researchers

Details

    Hugo Soudeyns , Ph.D.

    hugo.soudeyns@recherche-ste-justine.qc.ca
    Hugo Soudeyns
    Research Axis
    Viral and Immune Disorders and Cancers
    Research Theme
    Viral Diseases
    Address
    CHUSJ - Centre de Recherche

    Phone
    514 345-4931 #3907

    Fax
    514 345-4801

    Title

    • Associate Professor, Department of Microbiology and Immunology, University of Montreal.

    Education

    • Posdoctorate, Microbiology, University of Lausanne, 1999.
    • PhD, Microbiology, University of Montreal, 1997.

    Research Interests

    Hugo Soudeyn trained in microbiology and immunology. He has been mostly active in three main areas of HIV/AIDS research.

    The development and testing of antiretroviral drugs
    This work, performed during my master's degree, led to the identification of lamivudine (3TC), a widely-prescribed antiretroviral compound.

    The molecular genetics of HIV-1 gene expression
    This work led to the identification of intragenic hormone response elements within the HIV-1 genome.

    The study of host cell-mediated immune responses during acute and chronic HIV infection
    We observed TCR chain-specific expansions of T cells during primary HIV infection (PI), and realized that these expanded cell populations comprised HIV-specific cytotoxic T lymphocytes (CTL). We discovered that some of these clones underwent clonal exhaustion during PI, studied the compartmentalization of HIV-specific CTL between lymph nodes and peripheral blood, identified molecular evidence for the selection of CTL escape mutants during PI, and defined the effects of antiretrovirals on the mobilization of CTL responses.

    In collaboration with the CHU Sainte-Justine Centre maternel et infantile sur le sida, Dr Soudeyns has been involved in long-term efforts to characterize CTL responses in HIV-infected children. This work led to the identification of important differences in cell-mediated immunity between adults and children, and contributed to the understanding of the pathogenesis of paediatric HIV infection. In January 2000, Dr Soudeyns opened a research unit devoted to the study of viral immuno-pathology and childhood auto-immune diseases. His primary research interests now focus on mother-to-child transmission of hepatitis C virus (HCV), HCV-specific cell-mediated immunity during pregnancy and childhood, as well as T cell migration and targeting.

    Awards and Distinctions

    • PhD thesis featured on the Dean's Honor List, McGill University, 1997.
    • New Investigator Award (Basic Science), Canadian Association for HIV Research, 1996.

Publications

Ransy DG, Motorina A, Merindol N, Akouamba BS, Samson J, Lie Y, Napolitano LA, Lapointe N, Boucher M, Soudeyns H,
Evolution of HIV-1 coreceptor usage and coreceptor switching during pregnancy
AIDS Res Hum Retroviruses 2013 (sous presse).

Escobar-Gutiérrez A, Soudeyns H, Larouche A, Carpio-Pedroza JC, Martinez-Guarneros A, Vazquez-Chacon CA, Fonseca-Coronado S, Yamasaki LH, Ruiz-Tovar K, Cruz-Rivera M,
Vertical transmission of hepatitis C virus: a tale of multiple outcomes
Infect Genet Evol 2013 20: 465-70.

Le Campion A, Larouche A, Fauteux-Daniel S, Soudeyns H,
Pathogenesis of hepatitis C during pregnancy and childhood
Viruses 2012 4(12): 3531-3550.

Merindol N, Salem Fourati I, Brito RM, Grenier A, Charrier E, Cordeiro P, Caty M, Mezziani S, Malette B, Duval M, Alfieri C, Ovetchkine P, Le Deist F, Soudeyns H,
Reconstitution of protective immune responses against cytomegalovirus and varicella zoster virus does not require disease development in pediatric recipients of umbilical cord blood transplantation
J Immunol 2012 189(10): 5016-5028.

Larouche A, Gaëtan G, El-Bilali N, Quesnel-Vallières M, Martin S, Alvarez F, Shoukry NH, Soudeyns H,
Seronegative hepatitis C virus infection in a child infected via mother-to-child transmission
J Clin Microbiol 2012 50(7): 2515-2519.

Côté H, Soudeyns H, Thorne A, Alimenti A, Lamarre V, Maan EJ, Sattha B, Singer J, Lapointe N, Money DM, Forbes J, CIHR Emerging Team in HIV therapy, aging (CARMA), Wong J, Bitnun A, Samson L, Brophy J, Burdge D, Pick N, van Schalkwyk J, Montaner J, Harris M, Janssen P,
Leukocyte telomere length in HIV-infected and HIV-exposed uninfected children: shorter telomeres with uncontrolled HIV viremia
PLoS ONE 2012 7(7): e39266.

Imam T, Jitratkosol MH, Soudeyns H, Sattha B, Gadawski I, Maan E, Forbes J, Alimenti A, Lapointe N, Lamarre V, Money DM, Côté H, CIHR Team in Children's Pain,
Leukocyte telomere length in HIV-infected pregnant women treated with antiretroviral drugs during pregnancy and their uninfected infants
J Acquir Immune Defic Syndr 2012 60(5): 495-502.

Van der Linden D, Lapointe N, Kakkar F, Ransy DG, Motorina A, Maurice F, Soudeyns H, Lamarre V,
The young and the resistant: HIV-infected Canadian adolescents at the time of transfer to adult care
J Ped Infect Dis Soc 2012 (sous presse).

Lapierre P, Troesch M, Alvarez F, Soudeyns H,
Structural basis for broad neutralization of hepatitis C virus quasispecies
PLoS ONE 2011 (10): e26981.

Quesnel-Vallières M, Kouzayha I, Tran E, Barry I, Lasgi C, Merindol N, Boucher M, Lapointe N, Soudeyns H,
Novel HIV-1 recombinant forms in antenatal cohort, Montreal, Canada
Emerg Infect Dis 2011 17(2): 271-274.

Merindol N, Champagne MA, Duval M, Soudeyns H,
CD8+ T-cell reconstitution in recipients of umbilical cord blood transplantation and characteristics associated with leukemic relapse
Blood 2011 118(16): 4480-4488.

Merindol N, Charrier E, Duval M, Soudeyns H,
Complementary and contrasting roles of NK cells and T cells in pediatric umbilical cord blood transplantation
J Leukoc Biol 2011 90(1): 49-60.

Merindol N, Grenier A, Caty M, Charrier E, Duval A, Duval M, Champagne MA, Soudeyns H,
Umbilical cord blood T cells respond against the Melan-A/MART-1 tumor antigen and exhibit reduced alloreactivity as compared with adult blood-derived T cells
J Immunol 2010 185(2): 856-866.

Lavoie PM, Huang Q, Jolette E, Whalen M, Nuyt A-M, Audibert F, Speert D, Lacaze-Masmonteil T, Soudeyns H, Kollmann TK,
Profound lack of Interleukin (IL)-12/IL-23p40 in neonates born early in gestation is associated with an increased risk of sepsis
J Infect Dis 2010 202(11): 1754-1763.

Drouin C, Lamarche S, Bruneau J, Soudeyns H, Shoukry NH,
Cell-mediated immune responses directed against hepatitis C virus (HCV) alternate reading frame protein (ARFP) are undetectable during acute infection
J Clin Virol 2010 47(1): 102-103.

Allan SE, Alstad AN, Merindol N, Crellin NK, Amendola S, Bacchetta R, Naldini L, Roncarolo MG, Soudeyns H, Levings MK,
Generation of potent and stable human CD4+ T regulatory cells by activation-independent expression of FOXP3
Mol Ther 2008 16(1): 194-202.

Quesnel-Vallières M, Lemay M, Lapointe N, Martin S, Soudeyns H,
HCV quasispecies evolution during treatment with interferon alfa-2b and ribavirin in two children coinfected with HCV and HIV-1
J Clin Virol 2008 43(2): 236-240.

Ransy DG, Akouamba BS, Samson J, Lapointe N, Soudeyns H,
Immunité maternelle et transmission mère-enfant du VIH et du VHC: progrès récents et nouveaux défis
Médecine Sciences 2007 23(11): 991-996.

Boulassel MR, Samson J, Khammy A, Lapointe N, Soudeyns H, Routy JP,
Predictive value of interleukin-7 levels for virological response to treatment in HIV-1-infected children
Viral Immunol 2007 20(4): 649-656.

Troesch M, Meunier I, Lapierre P, Lapointe N, Alvarez F, Boucher M, Soudeyns H,
Study of a novel hypervariable region in hepatitis C virus (HCV) E2 envelope glycoprotein
Virology 2006 352(2): 357-367.

Marceau G, Lapierre P, Soudeyns H, Alvarez F,
LKM1 autoantibodies in chronic hepatitis C infection : a case of molecular mimicry?
Hepatology 2005 42(3): 675-682.

Akouamba BS, Viel J, Charest H, Merindol N, Samson J, Lapointe N, Brenner B, Lalonde R, Harrigan PR, Boucher M, Soudeyns H,
HIV-1 genetic diversity in antenatal cohort, Canada
Emerg Infect Dis 2005 11(8): 1230-1234.

Troesch M, Jalbert E, Canobio S, Boulassel MR, Routy JP, Bernard N, Bruneau J, Lapointe N, Boucher M, Soudeyns H,
Characterization of humoral and cell-mediated immune responses directed against hepatitis C virus F protein in subjects co-infected with hepatitis C virus and HIV-1
AIDS 2005 19(8): 775-784.

Martin S, Lapointe N, Soudeyns H,
Coinfection with hepatitis C virus and human immunodeficiency virus 1 in children: pathogenesis and screening
Arch Pediat Adol Med 2005 159(6): 598-599.

Canobio S, Guilbert C, Troesch M, Samson J, Lemay M, Pelletier V, Bernard-Bonnin A-C, Kozielski R, Lapointe N, Martin S, Soudeyns H,
Differing patterns of liver disease progression and hepatitis C virus (HCV) quasispecies evolution in children vertically coinfected with HCV and human immunodeficiency virus type 1
J Clin Microbiol 2004 42(9): 4365-4369.

Soudeyns H,
Analysis of the T cell receptor repertoire in HIV infection
Cellular aspects of HIV infection John Wiley-Liss Inc. 2002 127-146.

Soudeyns H, Pantaleo G,
Cytotoxic T cell responses in acute and chronic human immunodeficiency virus type-1 infection
Retroviral Immunology Humana Press 2001 213-235.

Soudeyns H, Campi G, Rizzardi GP, Lenge C, Demarest JF, Corey L, Tambussi G, Lazzarin A, Kaufmann D, Casorati G, Pantaleo G,
Initiation of antiretroviral therapy during primary HIV-1 infection induces rapid stabilization of the T cell receptor b chain repertoire and reduces the level of T cell oligoclonality
Blood 2000 95: 1743-1751.

Soudeyns H, Champagne P, Holloway C, Silvestri G, Ringuette N, Samson J, Lapointe N, Sékaly R,
Transcient T cell receptor BV-specific expansions of CD4+ and CD8+ T cells during the early phase of pediatric human immunodeficiency virus infection: characterization of expanded cell populations by T cell receptor phenotype
J Infect Dis 2000 181: 107-120.

 
 
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Edited by Olivier Cozette
Updated on 10/1/2014
Created on 9/18/2014
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