Viral and Immune Disorders and Cancers
CHUSJ - Centre de Recherche
514 345-4931 #3907
Associate Professor, Department of Microbiology and Immunology, University of Montreal.
Posdoctorate, Microbiology, University of Lausanne, 1999.
PhD, Microbiology, University of Montreal, 1997.
Hugo Soudeyn trained in microbiology and immunology. He has been mostly active in three main areas of HIV/AIDS research.
The development and testing of antiretroviral drugs
This work, performed during my master's degree, led to the identification of lamivudine (3TC), a widely-prescribed antiretroviral compound.
The molecular genetics of HIV-1 gene expression
This work led to the identification of intragenic hormone response elements within the HIV-1 genome.
The study of host cell-mediated immune responses during acute and chronic HIV infection
We observed TCR chain-specific expansions of T cells during primary HIV infection (PI), and realized that these expanded cell populations comprised HIV-specific cytotoxic T lymphocytes (CTL). We discovered that some of these clones underwent clonal exhaustion during PI, studied the compartmentalization of HIV-specific CTL between lymph nodes and peripheral blood, identified molecular evidence for the selection of CTL escape mutants during PI, and defined the effects of antiretrovirals on the mobilization of CTL responses.
In collaboration with the CHU Sainte-Justine Centre maternel et infantile sur le sida, Dr Soudeyns has been involved in long-term efforts to characterize CTL responses in HIV-infected children. This work led to the identification of important differences in cell-mediated immunity between adults and children, and contributed to the understanding of the pathogenesis of paediatric HIV infection. In January 2000, Dr Soudeyns opened a research unit devoted to the study of viral immuno-pathology and childhood auto-immune diseases. His primary research interests now focus on mother-to-child transmission of hepatitis C virus (HCV), HCV-specific cell-mediated immunity during pregnancy and childhood, as well as T cell migration and targeting.
Awards and Distinctions
PhD thesis featured on the Dean's Honor List, McGill University, 1997.
New Investigator Award (Basic Science), Canadian Association for HIV Research, 1996.
Ransy DG, Motorina A, Merindol N, Akouamba BS, Samson J, Lie Y, Napolitano LA, Lapointe N, Boucher M, Soudeyns H,
Evolution of HIV-1 coreceptor usage and coreceptor switching during pregnancy
AIDS Res Hum Retroviruses
Escobar-Gutiérrez A, Soudeyns H, Larouche A, Carpio-Pedroza JC, Martinez-Guarneros A, Vazquez-Chacon CA, Fonseca-Coronado S, Yamasaki LH, Ruiz-Tovar K, Cruz-Rivera M,
Vertical transmission of hepatitis C virus: a tale of multiple outcomes
Infect Genet Evol
Le Campion A, Larouche A, Fauteux-Daniel S, Soudeyns H,
Pathogenesis of hepatitis C during pregnancy and childhood
Merindol N, Salem Fourati I, Brito RM, Grenier A, Charrier E, Cordeiro P, Caty M, Mezziani S, Malette B, Duval M, Alfieri C, Ovetchkine P, Le Deist F, Soudeyns H,
Reconstitution of protective immune responses against cytomegalovirus and varicella zoster virus does not require disease development in pediatric recipients of umbilical cord blood transplantation
Larouche A, Gaëtan G, El-Bilali N, Quesnel-Vallières M, Martin S, Alvarez F, Shoukry NH, Soudeyns H,
Seronegative hepatitis C virus infection in a child infected via mother-to-child transmission
J Clin Microbiol
Côté H, Soudeyns H, Thorne A, Alimenti A, Lamarre V, Maan EJ, Sattha B, Singer J, Lapointe N, Money DM, Forbes J, CIHR Emerging Team in HIV therapy, aging (CARMA), Wong J, Bitnun A, Samson L, Brophy J, Burdge D, Pick N, van Schalkwyk J, Montaner J, Harris M, Janssen P,
Leukocyte telomere length in HIV-infected and HIV-exposed uninfected children: shorter telomeres with uncontrolled HIV viremia
Imam T, Jitratkosol MH, Soudeyns H, Sattha B, Gadawski I, Maan E, Forbes J, Alimenti A, Lapointe N, Lamarre V, Money DM, Côté H, CIHR Team in Children's Pain,
Leukocyte telomere length in HIV-infected pregnant women treated with antiretroviral drugs during pregnancy and their uninfected infants
J Acquir Immune Defic Syndr
Van der Linden D, Lapointe N, Kakkar F, Ransy DG, Motorina A, Maurice F, Soudeyns H, Lamarre V,
The young and the resistant: HIV-infected Canadian adolescents at the time of transfer to adult care
J Ped Infect Dis Soc
Lapierre P, Troesch M, Alvarez F, Soudeyns H,
Structural basis for broad neutralization of hepatitis C virus quasispecies
Quesnel-Vallières M, Kouzayha I, Tran E, Barry I, Lasgi C, Merindol N, Boucher M, Lapointe N, Soudeyns H,
Novel HIV-1 recombinant forms in antenatal cohort, Montreal, Canada
Emerg Infect Dis
Merindol N, Champagne MA, Duval M, Soudeyns H,
CD8+ T-cell reconstitution in recipients of umbilical cord blood transplantation and characteristics associated with leukemic relapse
Merindol N, Charrier E, Duval M, Soudeyns H,
Complementary and contrasting roles of NK cells and T cells in pediatric umbilical cord blood transplantation
J Leukoc Biol
Merindol N, Grenier A, Caty M, Charrier E, Duval A, Duval M, Champagne MA, Soudeyns H,
Umbilical cord blood T cells respond against the Melan-A/MART-1 tumor antigen and exhibit reduced alloreactivity as compared with adult blood-derived T cells
Lavoie PM, Huang Q, Jolette E, Whalen M, Nuyt A-M, Audibert F, Speert D, Lacaze-Masmonteil T, Soudeyns H, Kollmann TK,
Profound lack of Interleukin (IL)-12/IL-23p40 in neonates born early in gestation is associated with an increased risk of sepsis
J Infect Dis
Drouin C, Lamarche S, Bruneau J, Soudeyns H, Shoukry NH,
Cell-mediated immune responses directed against hepatitis C virus (HCV) alternate reading frame protein (ARFP) are undetectable during acute infection
J Clin Virol
Allan SE, Alstad AN, Merindol N, Crellin NK, Amendola S, Bacchetta R, Naldini L, Roncarolo MG, Soudeyns H, Levings MK,
Generation of potent and stable human CD4+ T regulatory cells by activation-independent expression of FOXP3
Quesnel-Vallières M, Lemay M, Lapointe N, Martin S, Soudeyns H,
HCV quasispecies evolution during treatment with interferon alfa-2b and ribavirin in two children coinfected with HCV and HIV-1
J Clin Virol
Ransy DG, Akouamba BS, Samson J, Lapointe N, Soudeyns H,
Immunité maternelle et transmission mère-enfant du VIH et du VHC: progrès récents et nouveaux défis
Boulassel MR, Samson J, Khammy A, Lapointe N, Soudeyns H, Routy JP,
Predictive value of interleukin-7 levels for virological response to treatment in HIV-1-infected children
Troesch M, Meunier I, Lapierre P, Lapointe N, Alvarez F, Boucher M, Soudeyns H,
Study of a novel hypervariable region in hepatitis C virus (HCV) E2 envelope glycoprotein
Marceau G, Lapierre P, Soudeyns H, Alvarez F,
LKM1 autoantibodies in chronic hepatitis C infection : a case of molecular mimicry?
Akouamba BS, Viel J, Charest H, Merindol N, Samson J, Lapointe N, Brenner B, Lalonde R, Harrigan PR, Boucher M, Soudeyns H,
HIV-1 genetic diversity in antenatal cohort, Canada
Emerg Infect Dis
Troesch M, Jalbert E, Canobio S, Boulassel MR, Routy JP, Bernard N, Bruneau J, Lapointe N, Boucher M, Soudeyns H,
Characterization of humoral and cell-mediated immune responses directed against hepatitis C virus F protein in subjects co-infected with hepatitis C virus and HIV-1
Martin S, Lapointe N, Soudeyns H,
Coinfection with hepatitis C virus and human immunodeficiency virus 1 in children: pathogenesis and screening
Arch Pediat Adol Med
Canobio S, Guilbert C, Troesch M, Samson J, Lemay M, Pelletier V, Bernard-Bonnin A-C, Kozielski R, Lapointe N, Martin S, Soudeyns H,
Differing patterns of liver disease progression and hepatitis C virus (HCV) quasispecies evolution in children vertically coinfected with HCV and human immunodeficiency virus type 1
J Clin Microbiol
Analysis of the T cell receptor repertoire in HIV infection
Cellular aspects of HIV infection
John Wiley-Liss Inc.
Soudeyns H, Pantaleo G,
Cytotoxic T cell responses in acute and chronic human immunodeficiency virus type-1 infection
Soudeyns H, Campi G, Rizzardi GP, Lenge C, Demarest JF, Corey L, Tambussi G, Lazzarin A, Kaufmann D, Casorati G, Pantaleo G,
Initiation of antiretroviral therapy during primary HIV-1 infection induces rapid stabilization of the T cell receptor b chain repertoire and reduces the level of T cell oligoclonality
Soudeyns H, Champagne P, Holloway C, Silvestri G, Ringuette N, Samson J, Lapointe N, Sékaly R,
Transcient T cell receptor BV-specific expansions of CD4+ and CD8+ T cells during the early phase of pediatric human immunodeficiency virus infection: characterization of expanded cell populations by T cell receptor phenotype
J Infect Dis