Chercheur

    Johnny Deladoëy , M.D. , Ph.D.

    johnny.deladoey@umontreal.ca
    Johnny Deladoëy
    Axe de recherche
    Santé métabolique et maladies complexes
    Thème de recherche
    Maladies génétiques et métaboliques au Québec : diagnostics, mécanismes et interventions
    Adresse
    CHUSJ

    Téléphone
    514 345-4931 #5032

    Formation

    • Spécialisation en endocrinologie et diabétologie pédiatrique (FMH), 2008
    • Spécialisation en pédiatrie (FMH), 2006
    • PhD en endocrinologie moléculaire, Université de Berne, Suisse, 2001
    • MD avec thèse, Université de Berne, Suisse, 1998
    • Cours en médecine expérimentale et biologie, Université de Zurich, Suisse, 1997-1998
    • Diplôme de médecine, Université de Berne, Suisse, 1996

    Intérêts de recherche

    Je me concentre sur les mécanismes moléculaires de l'hypothyroïdie congénitale (HC) secondaire à un défaut de migration de la thyroïde. L’HC est essentiellement sporadique, et des phénomènes non mendéliens pourraient être à l’origine de cette pathologie. Ma recherche vise à découvrir ces phénomènes, soit les variations du nombre de copies de novo et les modifications épigénétiques au niveau somatique.

Publications

Role for tissue-dependent methylation differences in the expression of FOXE1 in non-tumoral thyroid glands - Abu-Khudir R, Magne F, Chanoine JP, Deal C, Van Vliet G, Deladoëy J. Role for tissue-dependent methylation differences in the expression of FOXE1 in non-tumoral thyroid glands. J Clin Endocrinol Metab 2014; (sous presse).

Autonomous adenomas caused by somatic mutations of the thyroid-stimulating hormone receptor in children - Grob F, Deladoëy J, Legault L, Spigelblatt L, Fournier A, Vassart G, Van Vliet G. Autonomous adenomas caused by somatic mutations of the thyroid-stimulating hormone receptor in children. Horm Res Ped 2014; 81(2): 73-79.

Linear association between household income and metabolic control in children with insulin-dependent diabetes mellitus despite free access to health care - Deladoëy J, Henderson M, Geoffroy L. Linear association between household income and metabolic control in children with insulin-dependent diabetes mellitus despite free access to health care. J Clin Endocrinol Metab 2013; 98(5): E882-885.

Treating congenital hypothyroidism--which levothyroxine? - Deladoëy J, Van Vliet G. Treating congenital hypothyroidism--which levothyroxine?. Nat Rev Endocrinol 2013; 9(5) : 257-258.

A search for variables predicting cortisol response to low-dose corticotropin stimulation following supraphysiological doses of glucocorticoids - Wildi-Runge S, Deladoëy J, Bélanger C, Deal C, Van Vliet G, Alos N, Huot C. A search for variables predicting cortisol response to low-dose corticotropin stimulation following supraphysiological doses of glucocorticoids. J Pediatr 2013; 163(2): 484-488.e1.

Hypothyroidism in infants and children: neonatal screening - Van Vliet G, Deladoëy J. Hypothyroidism in infants and children: neonatal screening. Dans: Braverman LE, Cooper D (eds). The Thyroid: A Fundamental and Clinical Text, 10th edition. Philadelphia, PA. Lippincott, Williams & Wilkins, 2013; 787-802.

Thyroid function from birth to adolescence in Prader-Willi syndrome - Sharkia M, Michaud S, Berthier MT, Giguere Y, Stewart L, Deladoëy J, Deal C, Van Vliet G, Chanoine JP. Thyroid function from birth to adolescence in Prader-Willi syndrome. Hum Brain Mapp 2013; 163(3): 800-805.

Whole exome sequencing: opportunities in pediatric endocrinology - Samuels ME, Hasselmann C, Deal C, Deladoëy J, Van Vliet G. Whole exome sequencing: opportunities in pediatric endocrinology. Personalized Med 2013; (sous presse).

Bioinactive ACTH causing glucocorticoid deficiency - Samuels ME, Gallo-Payet N, Pinard S, Hasselmann C, Magne F, Patry L, Chouinard L, Schwartzentruber JA, René P, Sawyer N, Bouvier M, Djemli A, Delvin EE, Huot C, Eugène D, Deal C, Van Vliet G, Majewski J, Deladoëy J, FORGE Canada Consortium. Bioinactive ACTH causing glucocorticoid deficiency. J Clin Endocrinol Metab 2013; 98(2): 736-742.

Congenital hypothyroidism due to thyroid dysgenesis: from epidemiology to molecular mechanisms - Deladoëy J. Congenital hypothyroidism due to thyroid dysgenesis: from epidemiology to molecular mechanisms. Dans: Springer D (ed.). A New Look at Hypothyroidism. Rijeka (Croatia). InTech Publishing, 2012; 229-242.

A high prevalence of dual thyroid ectopy in congenital hypothyroidism: evidence for insufficient signaling gradients during embryonic thyroid migration or for the polyclonal nature of the thyroid gland? - Wildi-Runge S, Stoppa-Vaucher S, Lambert R, Turpin S, Van Vliet G, Deladoëy J. A high prevalence of dual thyroid ectopy in congenital hypothyroidism: evidence for insufficient signaling gradients during embryonic thyroid migration or for the polyclonal nature of the thyroid gland?. J Clin Endocrinol Metab 2012; 97(6): E978-981.

Evidence for calcitonin-producing cells in human lingual thyroids - Vandernoot I, Sartelet H, Abu-Khudir R, Chanoine JP, Deladoëy J. Evidence for calcitonin-producing cells in human lingual thyroids. J Clin Endocrinol Metab 2012; 97(3): 951-956.

46, XY gonadal dysgenesis: new SRY point mutation in two siblings with paternal germ line mosaicism - Stoppa-Vaucher S, Ayabe T, Paquette J, Patey N, Francoeur D, Vuissoz JM, Deladoëy J, Samuels ME, Ogata K, Deal C. 46, XY gonadal dysgenesis: new SRY point mutation in two siblings with paternal germ line mosaicism. Clin Genet 2012; 82(6): 505-513.

Is the incidence of congenital hypothyroidism really increasing? A 20-year retrospective population-based study in Québec - Deladoëy J, Ruel J, Giguere Y, Van Vliet G. Is the incidence of congenital hypothyroidism really increasing? A 20-year retrospective population-based study in Québec. J Clin Endocrinol Metab 2011; 96(8): 2422-2429.

An 8-year old girl with a lingual mass - Deladoëy J. An 8-year old girl with a lingual mass. Dans: Wartofsky L (ed.). Diagnostic Dilemmas: Images in Endocrinology. Endocrine Society, 2011; 160-163.

Is ultrasonography useful in predicting thyroid cancer in children with thyroid nodules and apparently benign cytopathologic features? - Saavedra J, Deladoëy J, Saint-Vil D, Boivin Y, Alos N, Deal C, Van Vliet G, Huot C. Is ultrasonography useful in predicting thyroid cancer in children with thyroid nodules and apparently benign cytopathologic features?. Horm Res Ped 2011; 75(4): 269-275.

Discovery of a fetal goiter on prenatal ultrasound in women treated for Graves' disease: first, do no harm - Stoppa-Vaucher S, Van Vliet G, Deladoëy J. Discovery of a fetal goiter on prenatal ultrasound in women treated for Graves' disease: first, do no harm. Thyroid 2011; 21(8): 931; author reply 932-933.

Variation by ethnicity in the prevalence of congenital hypothyroidism due to thyroid dysgenesis - Stoppa-Vaucher S, Van Vliet G, Deladoëy J. Variation by ethnicity in the prevalence of congenital hypothyroidism due to thyroid dysgenesis. Thyroid 2011; 21(1): 13-18.

Are guidelines for glucocorticoid coverage in adrenal insufficiency currently followed? - Leblicq C, Rottembourg D, Deladoëy J, Van Vliet G, Deal C. Are guidelines for glucocorticoid coverage in adrenal insufficiency currently followed?. J Pediatr 2011; 158(3): 492-498.e1.

Ectopic thyroid gland causing dysphonia: imaging and molecular studies - Stoppa-Vaucher S, Lapointe A, Turpin S, Rydlewski C, Vassart G, Deladoëy J. Ectopic thyroid gland causing dysphonia: imaging and molecular studies. J Clin Endocrinol Metab 2010; 95(10): 4509-4510.

Non-immune goiter and hypothyroidism in a 19-week fetus: a plea for conservative treatment - Stoppa-Vaucher S, Francoeur D, Grignon A, Alos N, Polhenz J, Hermanns P, Van Vliet G, Deladoëy J. Non-immune goiter and hypothyroidism in a 19-week fetus: a plea for conservative treatment. J Pediatr 2010; 156(6): 1026-1029.

Transcriptome, methylome and genomic variations analysis of ectopic thyroid glands - Abu-Khudir R, Paquette J, Lefort A, Libert F, Chanoine JP, Vassard G, Deladoëy J. Transcriptome, methylome and genomic variations analysis of ectopic thyroid glands. PLoS ONE 2010; 5(10): e13420.

Lethal respiratory failure and mild primary hypothyroidism in a term girl with a de novo heterozygous mutation in the TITF1/NKX2.1 gene - Maquet E, Costagliola S, Parma J, Christophe-Hobertus C, Oligny LL, Fournet JC, Robitaille Y, Vuissoz JM, Payot A, Laberge S, Vassard G, Van Vliet G, Deladoëy J. Lethal respiratory failure and mild primary hypothyroidism in a term girl with a de novo heterozygous mutation in the TITF1/NKX2.1 gene. J Clin Endocrinol Metab 2009; 94(1): 197-203.

A novel presentation of diffuse lung disease caused by congenital hypothyroidism - Shenoy A, Esquibies AE, Dunbar N, Dishop MK, Reyes-Mugica M, Langston C, Deladoëy J, Abu-Khudir R, Carpenter T, Bazzy-Asaad A. A novel presentation of diffuse lung disease caused by congenital hypothyroidism. J Pediatr 2009; 155(4): 593-595.

Pseudodominant inheritance of goitrous congenital hypothyroidism caused by TPO mutations: molecular and in silico studies - Deladoëy J, Pfarr N, Vuissoz JM, Parma J, Vassart G, Biesterfeld S, Polhenz J, Van Vliet G. Pseudodominant inheritance of goitrous congenital hypothyroidism caused by TPO mutations: molecular and in silico studies. J Clin Endocrinol Metab 2008; 93(2): 627-633.

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Créée le 22 juillet 2014
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