Chercheur

    Helen Trottier , Ph.D.

    helen.trottier@umontreal.ca
    Helen Trottier
    Axe de recherche
    Maladies virales, immunitaires et cancers
    Thème de recherche
    Infection et immunité
    Adresse
    CHUSJ - Centre de Recherche

    Téléphone
    514-345-4931, poste 7152

    Fax
    514 345-4801

    Titres

    • Professeur agrégé, Département de médecine sociale et préventive, Université de Montréal, 2008
    • Chercheur, Centre de recherche CHU Sainte-Justine, 2008

    Formation

    • Postdoctorat, Épidémiologie, Université McGill, 2008
    • PhD, Santé publique/épidémiologie, Université de Montréal, 2004
    • Certificat, Modélisation et épidémiologie des maladies infectieuses, London School of Hygiene and Tropical Medicine, 2002
    • Maîtrise, Démographie de la santé, Université de Montréal, 1999

    Intérêts de recherche

    Les principaux intérêts de recherche épidémiologique du Dr Helen Trottier concernent le domaine des maladies infectieuses, plus spécialement la dynamique des maladies infectieuses communes de l’enfance, la vaccination et les maladies infectieuses liées au cancer comme le virus du papillome humain (HPV), le virus d’Epstein-Barr (EBV) et autres virus Herpes Humain (HHV). Elle s’intéresse particulière à la transmission périnatale d’agents infectieux et à la transmission infectieuse par l’entremise de produits sanguins. Dr Trottier est titulaire de nombreux fonds de recherche et de bourses salariales des IRSC et du FRQS.

    Expertises de recherche

    • Epidémiologie
    • Transmission maladies infectieuses
    • Transmission périnatale d’agents infectieux
    • Virus associés au développement de cancer (HPV, HHV)
    • Produits sanguins / transfusion

    Prix et distinctions

    • Chercheur-boursier Junior 1, Fonds de la recherche en santé du Québec, 2009-2013.
    • Bourse salariale pour nouveau chercheur, Instituts de recherche en santé du Canada (IRSC), 2014-2019
    • Chercheur-Boursier Junior 2, Fonds de la recherche en santé du Canada, 2014-2018
    • Plusieurs millions en fonds de recherche des IRSC, Canadian Blood Services , fonds privés et autres. 

    Présentations

    1. Trottier H.  HPV carriage: the urgent need for education of physicians and public. EUROGIN 2016 Key findings in HPV related Cancer Bridging the gap between research and practice. Salzburg, Austria.  June 15, 2016.
    2. Trottier H.  How to respond effectively to negative press and reassure patients on safety of HPV Immunization.  EUROGIN 2016 Key findings in HPV related Cancer Bridging the gap between research and practice. Salzburg, Austria.  June 15, 2016.
    3. Trottier H.  Transmission of HPV: frequent patient questions. EUROGIN 2016 Key findings in HPV related Cancer Bridging the gap between research and practice. Salzburg, Austria.  June 15, 2016.
    4. Trottier H.  The risk of HPV vertical transmission routes. EUROGIN 2016 Key findings in HPV related Cancer Bridging the gap between research and practice. Salzburg, Austria.  June 18, 2016.
    5. Trottier H. Presentation of a research program on the perinatal transmission of Human Papillomavirus (HPV) and the impact of HPV among children. Meeting of the HPV Institute, Instituto de Pesquisa da Santa Casa de São Paulo, Brazil, March 25-26, 2013.
    6. Trottier H. Infection and Re-infection with HPV. Meeting of the HPV Instituto de Pesquisa da Santa Casa de São Paulo, Brazil, March 25-26, 2013.
    7. Trottier H. An updated in the TREASuRE study: transfusion-related Epstein-Barr Virus (EBV) infection among allogeneic stem cell transplant pediatric recipients: a multicenter prospective cohort study. 21st PALISI (Pediatric Acute Lung Injury & Sepsis Investigators), International meeting, Blood Net meeting, Snowbird, Utah, USA, March 13, 2013.
    8. Trottier H. Expert international invité. Public Health Workshop: screening, vaccine, research, surveillance and evaluation. 26th International Papillomavirus Conference, Montreal, Canada, 3-4 July 2010.
    9. Trottier H. Epidemiology of genital HPV infection in women: new evidences. EUROGIN 2010, Cervical Cancer Prevention: 20 Years of Progress and a Path to the Future - Monte-Carlo, France, February 20, 2010.
    10. Trottier H. Pathologies associées aux HPV, progrès et perspectives : Étendue de l'infection à HPV France, Europe et Monde. Progin 2010. Grimaldi Forum, Monte-Carlo (Monaco, France).  17 février 2010.

    Publications significatives

    Les noms soulignés sont les étudiants post-gradués du Dr Trottier.

    1. Trottier H, Mayrand MH, Coutlée F, Monnier P, Laporte L, Niyibizi J, Carceller AM, Fraser WD, Brassard P, Lacroix J, Francoeur D, Bédard MJ, Girard I, Audibert F. Human papillomavirus (HPV) perinatal transmission and risk of HPV persistence among children: design, methods and preliminary results of the HERITAGE study. Papillomavirus Research. 2016 Dec; 2: 145–152
    2. Trottier H, Robitaille N, Delage G, Buteau C, Tucci M, Lacroix J, Alfieri C. Detection Of Epstein-Barr Virus In Leukoreduced Blood Products. Vox Sang. 2016 Feb;110(2):199-201.
    3. Ndiaye C, Mena M, Alemany L, Arbyn M, Castellsagué X, Laporte L, Bosch FX, de Sanjosé S, Trottier H.  HPV DNA, E6/E7 mRNA, and p16INK4a detection in head and neck cancers: a systematic review and meta-analysis.  Lancet Oncol. 2014 Nov 15(12): 1319-31                   
    4. Rodier C, Lapointe A, Coutlée F, Mayrand MH, Dal Soglio D, Roger M, Trottier H.  Juvenile Respiratory Papillomatosis: Can we identify risk factors for severity? Journal of Clinical Virology. 2013; 85:1447–1458.
    5. Laprise C, De Pokomandy A, Baril JG, Dufresne S, Trottier H. Virologic failure following persistent low-level viremia in a cohort of HIV-positive patients: results from 12 years of observation. Clin Infect Dis. 2013 Nov;57(10):1489-96.
    6. Trottier H, Buteau C, Robitaille N, Duval M, Tucci M, Lacroix J, Alfieri C. Transfusion-related Epstein-Barr virus infection among stem cell transplant recipients: a retrospective cohort study in children. Transfusion.  2012 Dec;52(12):2653-63.
    7. Trottier H, Ferreira S, Thomann P, Costa MC, Sobrinho JS, Prado JC, Rohan TE, Villa LL, Franco EL. HPV infection and re-infection in adult women: the role of sexual activity and natural immunity. Cancer Res. 2010 Nov 1;70(21):8569-77. 

Publications

Association between Tenofovir exposure and reduced kidney function in a cohort of HIV-positive patients: Results from 10 years of follow-up - Laprise C, Baril JG, Dufresne S, Trottier H. Association between Tenofovir exposure and reduced kidney function in a cohort of HIV-positive patients: Results from 10 years of follow-up. Clin Infect Dis 2013; 56(4): 567-575.

Juvenile respiratory papillomatosis: risk factors for severity - Rodier C, Lapointe A, Coutlée F, Mayrand MH, Bouron-Dal Soglio D, Roger M, Trottier H. Juvenile respiratory papillomatosis: risk factors for severity. J Med Virol 2013; 85(8): 1447-1458.

Transfusion-related Epstein-Barr virus infection among stem cell transplant recipients: a retrospective cohort study in children - Trottier H, Buteau C, Robitaille N, Duval M, Tucci M, Lacroix J, Alfieri C. Transfusion-related Epstein-Barr virus infection among stem cell transplant recipients: a retrospective cohort study in children. Transfusion 2012; 52(12): 2653-2663.

Epidemiology of mucosal human papillomavirus (HPV) infections among adult and children - Trottier H. Epidemiology of mucosal human papillomavirus (HPV) infections among adult and children. Dans: Vanden Broeck D (ed.). Human Papillomavirus and Related Diseases - From Bench to Bedside - Research aspects. InTech, 2012; 1-17.

Human papillomavirus distribution in invasive cervical carcinoma in sub-Saharan Africa: could HIV explain the differences? - Ndiaye C, Alemany L, Ndiaye N, Kamaté B, Diop Y, Odida M, Banjo K, Tous S, Klaustermeier JE, Clavero O, Castellsagué X, Xavier Bosch F, Trottier H, de Sanjosé S. Human papillomavirus distribution in invasive cervical carcinoma in sub-Saharan Africa: could HIV explain the differences?. Trop Med Int Health 2012; 17(12): 1432-1440.

HAART and progression to high-grade anal intraepithelial neoplasia in men who have sex with men and are infected with HIV - de Pokomandy A, Rouleau D, Ghattas G, Trottier H, Vézina S, Côté P, Macleod J, Allaire G, Hadjeres R, Franco EL, Coutlée F. HAART and progression to high-grade anal intraepithelial neoplasia in men who have sex with men and are infected with HIV. Clin Infect Dis 2011; 52(9): 1174-1181.

Benefits of vaccinating young adult women against cervical cancer: a review of the evidence - Skinner SR, Allen D, Trottier H, Ronsse V, Castellsagué X. Benefits of vaccinating young adult women against cervical cancer: a review of the evidence. Gynecol Oncol 2011; 121(suppl.): S10-20.

Infectious diseases and cancer: HPV - Trottier H, Franco A. Infectious diseases and cancer: HPV. Dans: Krämer K), Kretzschmar M, Krickeberg K (eds,) . Modern infectious disease epidemiology: Concept, methods, mathematical models, public health. Springer, 2010; 409-430.

Human papillomavirus infection and reinfection in adult women: the role of sexual activity and natural immunity - Trottier H, Ferreira S, Thomann P, Costa MC, Sobrinho JS, Prado JC, Rohan TE, Villa L, Franco EL. Human papillomavirus infection and reinfection in adult women: the role of sexual activity and natural immunity. Cancer Res 2010; 70(21): 8569-8577.

Determinants of delays in treatment initiation in children and adolescents diagnosed with leukemia or lymphoma in Canada - Dang-Tan T, Trottier H, Mery LS, Morrison H, Barr R, Greenberg ML, Franco EL. Determinants of delays in treatment initiation in children and adolescents diagnosed with leukemia or lymphoma in Canada. Int J Cancer 2010; 126(8): 1936-1943.

Red blood cell transfusion threshold in postsurgical pediatric intensive care patients: A randomized clinical trial - Rouette J, Trottier H, Ducruet T, Beaunoyer M, Lacroix J, Tucci M, for the Canadian Critical Care Trials Group, and the PALISI Network. Red blood cell transfusion threshold in postsurgical pediatric intensive care patients: A randomized clinical trial. Ann Surg 2010; 251(3): 421-427.

Transfuser ou ne pas transfuser: Un choix déterminant pour les enfants hospitalisés en service de soins intensifs. [Improving use of red-cell transfusion in pediatric intensive care units] - Lacroix J, Trottier H, Tucci M. Transfuser ou ne pas transfuser: Un choix déterminant pour les enfants hospitalisés en service de soins intensifs. [Improving use of red-cell transfusion in pediatric intensive care units]. Médecine Sciences 2010; 25(11): 963-965.

Validation of dot blot hybridization and denaturing high performance liquid chromatography as reliable methods for TP53 codon 72 genotyping in molecular epidemiologic studies - Rabachini T, Trottier H, Franco EL, Villa L. Validation of dot blot hybridization and denaturing high performance liquid chromatography as reliable methods for TP53 codon 72 genotyping in molecular epidemiologic studies. BMC Genet 2010; 11: 44 (on line).

Persistence of an incident human papillomavirus infection and timing of cervical lesions in previously unexposed young women - Trottier H, Mahmud SM, Lindsay L, Jenkins D, Quint W, Wieting S, Schuind A, Franco EL, GSK HPV-001 Vaccine Study Group. Persistence of an incident human papillomavirus infection and timing of cervical lesions in previously unexposed young women. Cancer Epidemiol Biomarkers Prev 2009; 18(3): 854-862.

Epidemiology of mucosal human papillomavirus infection and associated diseases - Trottier H, Burchell AN. Epidemiology of mucosal human papillomavirus infection and associated diseases. Pub Health Genomics 2009; 12(5-6): 291-307.

[Improving use of red-cell transfusion in pediatric intensive care units] - Lacroix J, Tucci M, Trottier H. [Improving use of red-cell transfusion in pediatric intensive care units]. Méd Sci (Paris) 2009; 25(11): 963-966.

Low-risk human papillomavirus type 6 DNA load and integration in cervical samples from women with squamous intraepithelial lesions - Coutlée F, Trottier H, Gagnon S, Koushik A, Richardson H, Roger M, Ferenczy A, Franco EL. Low-risk human papillomavirus type 6 DNA load and integration in cervical samples from women with squamous intraepithelial lesions. J Clin Virol 2009; 45(2): 96-99.

Type-specific duration of human papillomavirus infection: implications for human papillomavirus screening and vaccination - Trottier H, Mahmud SM, Prado JCM, Sobrinho JS, Costa MC, Rohan TE, Villa L, Franco E. Type-specific duration of human papillomavirus infection: implications for human papillomavirus screening and vaccination. J Infect Dis 2008; 197(10): 1436-1447.

Reassessing the epidemiology of human papillomavirus infection: back to basics - Franco E, Trottier H. Reassessing the epidemiology of human papillomavirus infection: back to basics. Sex Transm Infect 2008; 35(3): 283-285.

Delays in diagnosis and treatment among children and adolescents with cancer in Canada - Dang-Tan T, Trottier H, Mery LS, Morrison H, Barr R, Greenberg ML, Franco EL. Delays in diagnosis and treatment among children and adolescents with cancer in Canada. Pediatr Blood Cancer 2008; 51(4): 468-474.

Role of repeated biopsy of the prostate in predicting disease progression in patients with prostate cancer on active surveillance - Al Otaibi M, Ross P, Fahmy N, Jeyaganth S, Trottier H, Sircar K, Bégin L, Souhami L, Kassouf W, Aprikian A, Tanguay S. Role of repeated biopsy of the prostate in predicting disease progression in patients with prostate cancer on active surveillance. Cancer 2008; 113(2): 286-292.

The epidemiology of genital human papillomavirus infection - Trottier H, Franco EL. The epidemiology of genital human papillomavirus infection. Vaccine 2006; Suppl 1 : S1-15.

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Créée le 22 juillet 2014
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