Chercheur

    Cheri Deal , Ph.D. , M.D.

    cheri.l.deal@umontreal.ca
    Cheri Deal
    Axe de recherche
    Pathologies fœtomaternelles et néonatales
    Thème de recherche
    Étude des mécanismes des malformations congénitales
    Adresse
    CHUSJ - Centre de Recherche

    Téléphone
    514 345-4931 #6209

    Fax
    514 345-4988

    Sommaire de carrière

    Cheri Deal a obtenu une bourse du Conseil de recherches médicales du Canada (IRSC) pour faire son doctorat (PhD) en médecine expérimentale à l'Université McGill, puis elle a complété son doctorat en médecine (MD) à l'Université de Montréal. Elle détient des certificats de spécialiste en pédiatrie pour les États-Unis et le Canada (CHU Sainte-Justine/Hôpital de Montréal pour enfants) et en endocrinologie pédiatrique. Elle a obtenu une bourse postdoctorale du Conseil de recherches médicales du Canada pour poursuivre des recherches en endocrinologie pédiatrique au sein du laboratoire du Dr Ron Rosenfeld à la Stanford University de 1989 à 1991. Cheri Deal est membre de l'équipe du service d'endocrinologie au CHU Sainte-Justine depuis 1992. Elle est également professeure titulaire au Département de pédiatrie de l'Université de Montréal et membre associée de la Faculté de médecine, Division médecine expérimentale de l'Université McGill. Au niveau administratif, elle était présidente du Groupe des endocrinologues pédiatriques du Canada (GPEC) de 1999 à 2001, présidente de la Société canadienne de l'endocrinologie et métabolisme (SCEM) de 2009 à 2011 ainsi que membre et secrétaire du Conseil d'administration du Fonds de la recherche en santé du Québec (FRSQ) de 1999 à 2006.

    Son principal intérêt de recherche porte sur la contribution de l'axe hormonal GH-IGF à la régulation de la croissance, et la biologie moléculaire des maladies rares. Dans son laboratoire elle a entre autres effectué des recherches sur la régulation génétique et épigénétique du facteur de croissance IGF-2. Elle a obtenu une subvention de l'Initiative canadienne pour la recherche sur le cancer du sein (ICRCS) pour examiner le rôle d'IGF-2 et de son récepteur dans le cancer du sein. Son deuxième champ d'intérêt concerne la régulation d'aspects divers de l'axe GH-IGF pendant la période postnatale, leur rôle dans le cadre de la carcinogenèse et de l'obésité chez l'enfant prépubère et à titre de cible d'intervention clinique chez les enfants ayant un syndrome de Turner. Dre Deal se voue à la recherche centrée sur les besoins des patients. Elle a contribué à l'élucidation des anomalies moléculaires associées à une vaste gamme de troubles endocriniens peu courants chez l'enfant, telles que le sydrome polyglandulaire autoimmune type 1 (APECED) et l’hypopituitarisme congénitale.. Elle a également participé aux études cliniques dont l'objectif était d'améliorer les conséquences des pathologies endocriniennes chez l'enfant telles que l'hypothyroïdisme congénitale et diverses syndromes tels que le S. de Turner et de Prader-Willi. Elle a plus que 100 articles publiés.

    Prix et distinctions

    • Prix de chercheur clinicien Lawson Wilkins Pediatric Endocrine Society Clinical Scholar, 1994
    • Bourses du Fonds de la recherche en santé du Québec, 1996, 2001 et 2004

Publications

Role for tissue-dependent methylation differences in the expression of FOXE1 in non-tumoral thyroid glands - Abu-Khudir R, Magne F, Chanoine JP, Deal C, Van Vliet G, Deladoëy J. Role for tissue-dependent methylation differences in the expression of FOXE1 in non-tumoral thyroid glands. J Clin Endocrinol Metab 2014; (sous presse).

Exploring the association between DICER1 mutations and differentiated thyroid carcinoma - de Kock L, Sabbaghian N, Bouron-Dal Soglio D, Guillerman RP, Park BK, Chami R, Deal C, Priest JR, Foulkes W. Exploring the association between DICER1 mutations and differentiated thyroid carcinoma. J Clin Endocrinol Metab 2014; (sous presse).

50 years ago in the Journal of Pediatrics: autoimmune disorders of endocrine glands - Deal C, Rogol A. 50 years ago in the Journal of Pediatrics: autoimmune disorders of endocrine glands. J Pediatr 2013; 163(6): 1669.

Associations between pituitary imaging abnormalities and clinical and biochemical phenotypes in children with congenital growth hormone deficiency: data from an international observational study - Deal C, Hasselmann C, Pfäffle RW, Zimmermann AG, Quigley CA, Child CJ, Shavrikova EP, Cutler GB Jr, Blum WF. Associations between pituitary imaging abnormalities and clinical and biochemical phenotypes in children with congenital growth hormone deficiency: data from an international observational study. Horm Res Ped 2013; 79(5): 283-292.

Growth Hormone Research Society Workshop Summary: Consensus guidelines for recombinant human growth hormone therapy in Prader-Willi syndrome - Deal C, Tony M, Höybye C, Allen DB, Tauber M, Christiansen JS, the 2011 GH in PWS Clinical Care Guidelines Workshop Participants. Growth Hormone Research Society Workshop Summary: Consensus guidelines for recombinant human growth hormone therapy in Prader-Willi syndrome. J Clin Endocrinol Metab 2013; 98(6): E1072-1087.

Development of additional pituitary hormone deficiencies in pediatric patients originally diagnosed with idiopathic isolated growth hormone deficiency - Blum WF, Deal C, Zimmermann AG, Shavrikova EP, Child CJ, Quigley CA, Drop SL, Cutler GB, Rosenfeld RG. Development of additional pituitary hormone deficiencies in pediatric patients originally diagnosed with idiopathic isolated growth hormone deficiency. Eur J Endocrinol 2013; 170(1): 13-21.

Quality of referral of short children to the paediatric endocrinologist and impact of a fax communication system - Chiniara L, Perry RJ, Van Vliet G, Huot C, Deal C. Quality of referral of short children to the paediatric endocrinologist and impact of a fax communication system. Paediatr Child Health 2013; 18(10): 533-537.

A pharmacogenomic approach to the treatment of children with GH deficiency or Turner syndrome - Clayton P, Chatelain P, Tatò L, Yoo H, Ambler GR, Belgorosky A, Quinteiro S, Deal C, Stevens A, Raelson J, Croteau P, Destenaves B, Olivier C. A pharmacogenomic approach to the treatment of children with GH deficiency or Turner syndrome. Eur J Endocrinol 2013; 169(3): 277-289.

Personalized approach to growth hormone treatment: clinical use of growth prediction models - Wit JM, Ranke MB, Albertsson-Wikland K, Carrascosa A, Rosenfeld RG, Van Buuren S, Kristrom B, Schoenau E, Audi L, Hokken-Koelega A, Bang P, Jung H, Blum WF, Silverman L, Cohen P, Cianfarani S, Deal C, Clayton P, de Graaff L, Dahlgren J, Kleintjens J, Roelants M. Personalized approach to growth hormone treatment: clinical use of growth prediction models. Horm Res Ped 2013; 79(5): 257-270.

GH treatment to final height produces similar height gains in patients with SHOX deficiency and Turner syndrome: results of a multicenter trial - Blum WF, Ross JL, Zimmermann AG, Quigley CA, Child CJ, Kalifa G, Deal C, Drop SL, Rappold G, Cutler GB Jr. GH treatment to final height produces similar height gains in patients with SHOX deficiency and Turner syndrome: results of a multicenter trial. J Clin Endocrinol Metab 2013; 98(8): E1383-1392.

Thyroid function from birth to adolescence in Prader-Willi syndrome - Sharkia M, Michaud S, Berthier MT, Giguere Y, Stewart L, Deladoëy J, Deal C, Van Vliet G, Chanoine JP. Thyroid function from birth to adolescence in Prader-Willi syndrome. Hum Brain Mapp 2013; 163(3): 800-805.

Maternal and fetal leptin, adiponectin levels and associations with fetal insulin sensitivity - Luo ZC, Nuyt A-M, Delvin EE, Fraser W, Julien P, Audibert F, Girard I, Shatenstein B, Deal C, Grenier E, Garofalo C, Levy E. Maternal and fetal leptin, adiponectin levels and associations with fetal insulin sensitivity. Obesity 2013; 21(1): 210-216.

Bioinactive ACTH causing glucocorticoid deficiency - Samuels ME, Gallo-Payet N, Pinard S, Hasselmann C, Magne F, Patry L, Chouinard L, Schwartzentruber JA, René P, Sawyer N, Bouvier M, Djemli A, Delvin EE, Huot C, Eugène D, Deal C, Van Vliet G, Majewski J, Deladoëy J, FORGE Canada Consortium. Bioinactive ACTH causing glucocorticoid deficiency. J Clin Endocrinol Metab 2013; 98(2): 736-742.

A search for variables predicting cortisol response to low-dose corticotropin stimulation following supraphysiological doses of glucocorticoids - Wildi-Runge S, Deladoëy J, Bélanger C, Deal C, Van Vliet G, Alos N, Huot C. A search for variables predicting cortisol response to low-dose corticotropin stimulation following supraphysiological doses of glucocorticoids. J Pediatr 2013; 163(2): 484-488.e1.

Whole exome sequencing: opportunities in pediatric endocrinology - Samuels ME, Hasselmann C, Deal C, Deladoëy J, Van Vliet G. Whole exome sequencing: opportunities in pediatric endocrinology. Personalized Med 2013; (sous presse).

Abnormal motor cortex excitability is associated with reduced cortical thickness in X monosomy - Lepage JF, Clouchoux C, Lassonde M, Evans AC, Deal C, Théorêt H. Abnormal motor cortex excitability is associated with reduced cortical thickness in X monosomy. Hum Brain Mapp 2013; 34(4): 936-944.

Muscle-bone characteristics in children with Prader-Willi syndrome - Edouard T, Deal C, Van Vliet G, Gaulin N, Moreau A, Rauch F, Alos N. Muscle-bone characteristics in children with Prader-Willi syndrome. J Clin Endocrinol Metab 2012; 97(2): E275-281.

46, XY gonadal dysgenesis: new SRY point mutation in two siblings with paternal germ line mosaicism - Stoppa-Vaucher S, Ayabe T, Paquette J, Patey N, Francoeur D, Vuissoz JM, Deladoëy J, Samuels ME, Ogata K, Deal C. 46, XY gonadal dysgenesis: new SRY point mutation in two siblings with paternal germ line mosaicism. Clin Genet 2012; 82(6): 505-513.

Maternal and fetal IGF-I and IGF-II levels, fetal growth, and gestational diabetes - Luo ZC, Nuyt A-M, Delvin EE, Audibert F, Girard I, Shatenstein B, Cloutier A, Cousineau J, Djemli A, Deal C, Levy E, Wu Y, Julien P, Fraser W. Maternal and fetal IGF-I and IGF-II levels, fetal growth, and gestational diabetes. J Clin Endocrinol Metab 2012; 97(5): 1720-1728.

Pituitary blastoma: a unique embryonal tumor - Scheithauer BW, Horvath E, Abel TW, Robital Y, Park SH, Osamura RY, Deal C, Lloyd RV, Kovacs K. Pituitary blastoma: a unique embryonal tumor. Pituitary 2012; 15(3): 365-373.

Meier-Gorlin syndrome: growth and secondary sexual development of a microcephalic primordial dwarfism disorder - de Munnik SA, Otten BJ, Schoots J, Bicknell LS, Aftimos S, Al-Aama J, van Bever Y, Bober M, Born GF, Clayton-Smith J, Deal C, Edrees AY, Feingold M, Fryer A, Van Hagen JM, Hennekam RC, Jansweijer MC, Johnson D, Kant SG, Opitz JM, Ramadevi AR, Reardon W, Ross A, Sarda P, Schrander-Stumpel CT, Sluiter AE, Temple IK, Terhal PA, Toutain A, Wise CA, Wright M, Skidmore D, Samuels ME, Hoefsloot LH, Knoers NV, Brunner HG, Jackson AP, Bongers EM. Meier-Gorlin syndrome: growth and secondary sexual development of a microcephalic primordial dwarfism disorder. Am J Med Genet A 2012; 158A(11): 2733-2742.

Pituitary choriocarcinoma in an adolescent male: tumor-derived CG and GH delay diagnosis - Wildi-Runge S, Crevier L, Carret AS, Robitaille Y, Deal C. Pituitary choriocarcinoma in an adolescent male: tumor-derived CG and GH delay diagnosis. Growth Horm IGF Res 2011; 21(3): 181-184.

Severe cortisol deficiency associated with reversible growth hormone deficiency in two infants: what is the link? - McEachern RR, Drouin J, Metherell L, Huot C, Van Vliet G, Deal C. Severe cortisol deficiency associated with reversible growth hormone deficiency in two infants: what is the link?. J Clin Endocrinol Metab 2011; 96(9): 2670-2674.

Are guidelines for glucocorticoid coverage in adrenal insufficiency currently followed? - Leblicq C, Rottembourg D, Deladoëy J, Van Vliet G, Deal C. Are guidelines for glucocorticoid coverage in adrenal insufficiency currently followed?. J Pediatr 2011; 158(3): 492-498.e1.

Is ultrasonography useful in predicting thyroid cancer in children with thyroid nodules and apparently benign cytopathologic features? - Saavedra J, Deladoëy J, Saint-Vil D, Boivin Y, Alos N, Deal C, Van Vliet G, Huot C. Is ultrasonography useful in predicting thyroid cancer in children with thyroid nodules and apparently benign cytopathologic features?. Horm Res Ped 2011; 75(4): 269-275.

Mutations in origin recognition complex gene ORC4 cause Meier-Gorlin syndrome - Guernsey DL, Matsuoka M, Jiang H, Evans S, Macgillivray C, Nightingale M, Perry S, Ferguson M, LeBlanc M, Paquette J, Patry L, Rideout A, Thomas A, Orr A, McMaster CR, Michaud JL, Deal C, Langlois S, Superneau DW, Parkash S, Ludman M, Skidmore D, Samuels ME. Mutations in origin recognition complex gene ORC4 cause Meier-Gorlin syndrome. Nat Genet 2011; 43(4): 360-364.

Child health, developmental plasticity, and epigenetic programming - Hochberg Z, Feil R, Constancia M, Fraga M, Junien C, Carel JC, Boileau P, Le Bouc Y, Deal C, Lillycrop K, Scharfmann R, Sheppard A, Skinner M, Szyf M, Waterland RA, Waxman DJ, Whitelaw E, Ong K, Albertsson-Wikland K. Child health, developmental plasticity, and epigenetic programming. Endocr Rev 2011; 32(2): 159-224.

Prevalence and incidence of diabetes mellitus in GH-treated children and adolescents: analysis from the GeNeSIS observational research program - Child CJ, Zimmermann AG, Scott RS, Cutler GB Jr, Battelino T, Blum WF, Deal C, GeNeSIS International Advisory Board. Prevalence and incidence of diabetes mellitus in GH-treated children and adolescents: analysis from the GeNeSIS observational research program. J Clin Endocrinol Metab 2011; 96(6): E1025-1034.

21-Hydroxylase epitopes are targeted by CD8 T cells in autoimmune Addison's disease - Rottembourg D, Deal C, Lambert M, Mallone R, Carel JC, Lacroix A, Caillat-Zucman S, Le Deist F. 21-Hydroxylase epitopes are targeted by CD8 T cells in autoimmune Addison's disease. J Autoimmun 2010; 35(4): 309-315.

Combining multicriteria decision analysis, ethics and health technology assessment: applying the EVIDEM decision-making framework to growth hormone for Turner syndrome patients - Goetghebeur MM, Wagner M, Khoury H, Rindress D, Grégoire JP, Deal C. Combining multicriteria decision analysis, ethics and health technology assessment: applying the EVIDEM decision-making framework to growth hormone for Turner syndrome patients. Cost Eff Resour Alloc 2010; 8: 4 (on line).

Risk of autoimmune diabetes in APECED: association with short alleles of the 5'insulin VNTR - Paquette J, Varin D, Hamelin C, Hallgren A, Kampe O, Carel JC, Perheentupa J, Deal C. Risk of autoimmune diabetes in APECED: association with short alleles of the 5'insulin VNTR. Genes Immun 2010; 11(7): 590-597.

Pericardial effusion in severe hypothyroidism in children - Martinez-Soto T, Deal C, Stephure DK, Boutin C, Djemli A, Ho J. Pericardial effusion in severe hypothyroidism in children. J Pediatr Endocr Met 2010; 23(11): 1165-1168.

Maternal glucose tolerance in pregnancy affects fetal insulin sensitivity - Luo ZC, Delvin EE, Fraser W, Audibert F, Deal C, Julien P, Girard I, Shear R, Levy E, Nuyt A-M. Maternal glucose tolerance in pregnancy affects fetal insulin sensitivity. Diabetes Care 2010; 33(9): 2055-2061.

Retrospective study of the potential benefits and adverse events during growth hormone treatment in children with Prader-Willi syndrome - Fillion M, Deal C, Van Vliet G. Retrospective study of the potential benefits and adverse events during growth hormone treatment in children with Prader-Willi syndrome. J Pediatr 2009; 154(2): 230-233.

Consensus statement on the use of GnRH analogs in children - Carel JC, Eugster EA, Rogol A, Ghizzoni L, Palmert MR, Deal C, on behalf the of members of the ESPE-LWPE GnrH analogs consensus conference group. Consensus statement on the use of GnRH analogs in children. Pediatrics 2009; 123(4): e752-62.

Molecular studies of a patient with complete androgen insensitivity and a 47,XXY karyotype - Girardin C, Deal C, Lemyre E, Paquette J, Lumbroso R, Beitel LK, Trifiro MA, Van Vliet G. Molecular studies of a patient with complete androgen insensitivity and a 47,XXY karyotype. J Pediatr 2009; 155(3): 439-443.

Insulin-like growth factor-binding protein-1: serum levels, promoter polymorphism, and associations with components of the metabolic syndrome in short subjects born small for gestational age - Van der Kaay D, Deal C, de Kort S, Willemsen R, Leunissen R, Ester W, Paquette J, van Doorn J, Hokken-Koelega A. Insulin-like growth factor-binding protein-1: serum levels, promoter polymorphism, and associations with components of the metabolic syndrome in short subjects born small for gestational age. J Clin Endocrinol Metab 2009; 94(4): 1386-1392.

Genetic and epigenetic variability in the gene for IGFBP-3 (IGFBP3): correlation with serum IGFBP-3 levels and growth in short children born small for gestational age - Van der Kaay D, Hendriks E, Ester W, Leunissen RWJ, Willemsen MA, de Kort WS, Paquette J, Hokken-Koelega A, Deal C. Genetic and epigenetic variability in the gene for IGFBP-3 (IGFBP3): correlation with serum IGFBP-3 levels and growth in short children born small for gestational age. Growth Horm IGF Res 2009; 19(3): 198-205.

Comparison of adolescents with Klinefelter syndrome according to the circumstances of diagnosis: amniocentesis vs clinical signs - Girardin C, Lemyre E, Alos N, Deal C, Huot C, Van Vliet G. Comparison of adolescents with Klinefelter syndrome according to the circumstances of diagnosis: amniocentesis vs clinical signs. Horm Res 2009; 72(2): 98-105.

Consensus statement on the diagnosis and treatment of children with idiopathic short stature: a summary of the Growth Hormone Research Society, The Lawson Wilkins Pediatric Endocrine Society and the European Society for Pediatric Endocrinology Workshop - Cohen P, Rogol A, Deal C, Saenger P, Reiter EO, Ross JL, Chernausek SD, Savage MO, Wit JM, on behalf of the 2007 ISS Consensus Workshop participants.. Consensus statement on the diagnosis and treatment of children with idiopathic short stature: a summary of the Growth Hormone Research Society, The Lawson Wilkins Pediatric Endocrine Society and the European Society for Pediatric Endocrinology Workshop. J Clin Endocrinol Metab 2008; 93(11): 4210-4217.

Impact of patient characteristics and clinical factors on the decision to initiate growth hormone treatment in Turner syndrome - Khatchadourian K, Huot C, Alos N, Van Vliet G, Deal C. Impact of patient characteristics and clinical factors on the decision to initiate growth hormone treatment in Turner syndrome. Horm Res 2008; 70(5): 300-308.

Magenetic resonance imaging in congenital hypopituitarism: technical aspects - Deal C, Décarie JC. Magenetic resonance imaging in congenital hypopituitarism: technical aspects. Dans: Deal C (eds). Magnetic Resonance Imaging in Congenital Hypopitiutarism: A reference Guide. London (UK). Remedica Medical Education and Publishing, 2007; 1-17.

Retard pubertaire - Girard M, Deal C. Retard pubertaire. Dans: Turgeon J, Bernard-Bonnin AC, Gervais P, Ovetchkine P, Gauthier M (eds). Dictionnaire de thérapeutique pédiatrique Weber, 2e édition. Boucherville. Gaëtan Morin, 2007; 1121-1127.

Prophylactic thyroidectomy in pediatric carriers of MEN2A or familial medullary thyroid carcinoma (FMTC): mutation at C620 is associated with Hirschprung's disease - Butter A, Gagné J, Al-Jazaeri A, Emran MA, Deal C, Saint-Vil D. Prophylactic thyroidectomy in pediatric carriers of MEN2A or familial medullary thyroid carcinoma (FMTC): mutation at C620 is associated with Hirschprung's disease. J Pediatr Surg 2007; 42(1): 203-206.

Identification of upstream stimulatory factor binding sites in the human IGFBP3 promoter and potential implication of adjacent single-nucleotide polymorphisms and responsiveness to insulin - Paquette J, Bessette B, Ledru E, Deal C. Identification of upstream stimulatory factor binding sites in the human IGFBP3 promoter and potential implication of adjacent single-nucleotide polymorphisms and responsiveness to insulin. Endocrinology 2007; 148(12): 6007-6018.

Growth hormone is effective in treatment of short stature associated with short stature homeobox-containing gene deficiency: Two-year results of a randomized, controlled, multicenter trial - Blum WF, Crowe BJ, Quigley CA, Jung H, Cao D, Ross JL, Braun L, Rappold G, SHOX Study Group including, Deal C. Growth hormone is effective in treatment of short stature associated with short stature homeobox-containing gene deficiency: Two-year results of a randomized, controlled, multicenter trial . J Clin Endocrinol Metab 2007; 92(1): 219-228.

Normal minipuberty of infancy in boys with Prader-Willi syndrome - Filion M, Deal C, Van Vliet G. Normal minipuberty of infancy in boys with Prader-Willi syndrome. J Pediatr 2006; 149(6): 874-876.

Genomic imprinting in Turner syndrome: effects on response to growth hormone and on risk of sensorinal hearing loss - Hamelin C, Anglin G, Quigley CA, Deal C, Van Vliet G, on behalf of the Canadian GH Advisory Committee. Genomic imprinting in Turner syndrome: effects on response to growth hormone and on risk of sensorinal hearing loss. J Clin Endocrinol Metab 2006; 91(8): 3002-3010.

Tracing the origins of " fetal origins " of adult diseases: programming by oxidative stress? - Luo ZC, Fraser W, Julien P, Deal C, Audibert F, Smith GN, Xiong X, Walker M. Tracing the origins of " fetal origins " of adult diseases: programming by oxidative stress? . Med Hypotheses 2006; 66(1): 38-44.

Is congenital growth hormone deficiency ever transient? - Deal C. Is congenital growth hormone deficiency ever transient?. Ped Endocrinol Rev 2005; 2: 355-362.

Primary adrenal insufficiency in children: twenty years experience at the Sainte-Justine Hospital, Montreal - Perry RJ, Kecha O, Paquette J, Huot C, Van Vliet G, Deal C. Primary adrenal insufficiency in children: twenty years experience at the Sainte-Justine Hospital, Montreal. J Clin Endocrinol Metab 2005; 90(6): 3243-3250.

Congenital isolated adrenocorticotropin deficiency: an underestimated cause of neonatal death, explained by TPIT gene mutations - Vallette-Kasic S, Brue T, Pulichino A-M, Gueydan M, Barlier A, David M, Nicolino M, Malpuech G, Déchelotte P, Deal C, Van Vliet G, De Vroede M, Riepe FG, Partsch CJ, Sippell WG, Berberoglu M, Atasay B, de Zegher F, Beckers D, Kyllo J, Donohoue P, Fassnacht M, Hahner S, Allolio B, Noordam K, Dunkel L, Hero M, Pigeon B, Weill J, Yigit S, Brauner R, Heinrich JJ, Cummings E, Riddell C, Enjalbert A, Drouin J. Congenital isolated adrenocorticotropin deficiency: an underestimated cause of neonatal death, explained by TPIT gene mutations. J Clin Endocrinol Metab 2005; 90(3): 1323-1331.

Impact of Growth Hormone supplementation on adult height in Turner syndrome: results of the Canadian randomized controlled trial - Stephure DK, Van Vliet G, Deal C, Huot C, The Canadian Growth Hormone Advisory Committee. Impact of Growth Hormone supplementation on adult height in Turner syndrome: results of the Canadian randomized controlled trial. J Clin Endocrinol Metab 2005; 90(6): 3360-3366.

Sudden death in growth hormone-treated children with Prader-Willi syndrome - Van Vliet G, Deal C, Crock P, Robitaille Y, Oligny LL. Sudden death in growth hormone-treated children with Prader-Willi syndrome. J Pediatr 2004; 144(1): 129-131.

Cognition and behavior at school entry in children with congenital hypothyroidism treated early with high-dose levothyroxine - Simoneau-Roy J, Marti S, Deal C, Huot C, Robaey P, Van Vliet G. Cognition and behavior at school entry in children with congenital hypothyroidism treated early with high-dose levothyroxine. J Pediatr 2004; 144(6): 747-752.

Catch-up growth in severe juvenile hypothyroidism: Treatment with a GnRH analog - Teng L, Bui H, Bachrach L, Lee P, Gagné N, Deal C, Wilson D. Catch-up growth in severe juvenile hypothyroidism: Treatment with a GnRH analog. J Clin Endocrinol Metab 2004; 17(3): 345-354.

A neonatal form of isolated ACTH deficiency frequently associated with Tpit gene mutations - Vallette-Kasic S, Pulichino A-M, Gueydan M, Barlier A, David M, Malpuech G, Deal C, Van Vliet G, De Vroede M, Riepe FG, Partsch CJ, Sippell WG, Berberoglu M, Atasay B, de Zegher F, Kyllo J, Donohoue P, Déchelotte P, Fassnacht M, Noordam K, Dunkel L, Pigeon B, Weill J, Yigit S, Brauner R, Léger J, Heinrich JJ, Enjalbert A, Brue T, Drouin J. A neonatal form of isolated ACTH deficiency frequently associated with Tpit gene mutations. Endocr Res 2004; 30(4): 943-944.

Polymorphisms and mutations in the GH-IGF axis in very short children born SGA due to IUGR, and the implications for the patients in childhood and adult life - Deal C. Polymorphisms and mutations in the GH-IGF axis in very short children born SGA due to IUGR, and the implications for the patients in childhood and adult life. Horm Res 2003; 25(suppl. 1): 130.

IGF-1 transcript levels in whole-liver tissue, in freshly isolated hepatocytes, and in cultured hepatocytes from lean and obese Zucker rats - Tenoutasse S, Van Vliet G, Ledru E, Deal C. IGF-1 transcript levels in whole-liver tissue, in freshly isolated hepatocytes, and in cultured hepatocytes from lean and obese Zucker rats. Horm Res 2003; 59(3): 135-141.

Human and mouse TPIT gene mutations cause early onset pituitary ACTH deficiency - Pulichino A-M, Vallette-Kasic S, Couture C, Gauthier Y, Brue T, David M, Malpuech G, Deal C, Van Vliet G, De Vroede M, Riepe FG, Partsch CJ, Sippell WG, Berberoglu M, Atasay B, Drouin J. Human and mouse TPIT gene mutations cause early onset pituitary ACTH deficiency. Gene Dev 2003; 17(6): 711-716.

Reversible metaphyseal dysplasia in two children with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy: Clinical and molecular studies - Harris MB, Kecha O, Deal C, Rolfe Howlett C, Deiss D, Tobias V, Simoneau-Roy J. Reversible metaphyseal dysplasia in two children with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy: Clinical and molecular studies. J Clin Endocrinol Metab 2003; 88(10): 4576-4585.

ETV6-NTRK3 transformation requires insulin-like growth factor 1 receptor signaling and is associated with constitutive IRS-1 tyrosine phosphorylation - Morrison KB, Tognon CE, Garnett MJ, Deal C, Sorenson PH. ETV6-NTRK3 transformation requires insulin-like growth factor 1 receptor signaling and is associated with constitutive IRS-1 tyrosine phosphorylation. Oncogene 2002; 21(37): 2684-2695.

Novel promoter polymorphism in IGFBP3: correlation with serum levels and interaction with known regulators - Deal C, Ma J, Wilkin F, Paquette J, Rozen F, Hudson T, Stampfer M, Pollak M. Novel promoter polymorphism in IGFBP3: correlation with serum levels and interaction with known regulators. J Clin Endocrinol Metab 2001; 86(3): 1274-1280.

Genetic and non-genetic factors associated with variation of plasma levels of insulin-like growth factor-1 (IGF-I) and IGF-binding protein-3 (IGFBP-3) in healthy premenopausal women - Jernström H, Deal C, Wilkin F, Chu W, Tao Y, Majeed N, Hudson T, Narod S, Pollak M. Genetic and non-genetic factors associated with variation of plasma levels of insulin-like growth factor-1 (IGF-I) and IGF-binding protein-3 (IGFBP-3) in healthy premenopausal women. Cancer Epidemiol Biomarmarkers Prev 2001; 10(4): 377-384.

Genetic factors related to racial variation in plasma levels of insulin-like growth factor-1: Implications for pre-menopausal breast cancer risk - Jernström H, Chu W, Vesprini D, Tao Y, Majeed N, Deal C, Pollak M, Narod S. Genetic factors related to racial variation in plasma levels of insulin-like growth factor-1: Implications for pre-menopausal breast cancer risk. Mol Genet Metab 2001; 72(2): 144-154.

Molecular characterization of a pediatric pheochromocytoma with suspected bilateral disease - Mircescu H, Wilkin F, Paquette J, Oligny LL, Decaluwé H, Gaboury L, Nolet S, Van Vliet G, Deal C. Molecular characterization of a pediatric pheochromocytoma with suspected bilateral disease. J Pediatr 2001; 138(2): 269-273.

Human placental trophoblasts secrete a disintegrin metalloproteinase very similar to the IGFBP-3 protease in human pregnancy serum - Irwin JC, Suen LF, Cheng BH, Martin R, Cannon P, Deal C, Giudice L. Human placental trophoblasts secrete a disintegrin metalloproteinase very similar to the IGFBP-3 protease in human pregnancy serum. Endocrinology 2000; 141: 666-674.

Pediatric adrenocortical tumors : molecular events leading to insulin-like growth factor-II overexpression - Wilkin F, Gagné N, Paquette J, Oligny LL, Deal C. Pediatric adrenocortical tumors : molecular events leading to insulin-like growth factor-II overexpression. J Clin Endocrinol Metab 2000; 85: 2048-2056.

H19 sense and antisense transgenes modify insulin-like growth factor-II mRNA levels - Wilkin F, Paquette J, Ledru E, Hamelin C, Pollak M, Deal C. H19 sense and antisense transgenes modify insulin-like growth factor-II mRNA levels. Eur J Biochem 2000; 267: 1-9.

Hyperfunctioning malignant thyroid nodule in an eleven-year-old girl: Pathological and molecular study - Mircescu H, Parma J, Huot C, Deal C, Oligny LL, Vassard G, Van Vliet G. Hyperfunctioning malignant thyroid nodule in an eleven-year-old girl: Pathological and molecular study. J Pediatr 2000; 137(4): 585-587.

Outcome of Pediatric Graves' Disease after treatment with antithyroid medication and radioiodine - Ward L, Huot C, Lambert R, Deal C, Collu R, Van Vliet G. Outcome of Pediatric Graves' Disease after treatment with antithyroid medication and radioiodine. Clin Invest Med 1999; 22: 132-139.

Severe autoimmune polyendocrinopathy-Candidiasis-Ectodermal dystrophy in an adolescent girl with a novel AIRE mutation: Response to immunosuppressive therapy - Ward L, Paquette J, Seidman EG, Huot C, Alvarez F, Crock P, Delvin EE, Kampe O, Deal C. Severe autoimmune polyendocrinopathy-Candidiasis-Ectodermal dystrophy in an adolescent girl with a novel AIRE mutation: Response to immunosuppressive therapy. J Clin Endocrinol Metab 1999; 84: 844-852.

IGF-II expression in transfected human embryonic kidney fibroblasts does not alter H19 gene expression - Keiss W, Paquette J, Koepf G, Wolf E, Deal C. IGF-II expression in transfected human embryonic kidney fibroblasts does not alter H19 gene expression. Biochem Biophys Res Commun 1999; 255: 226-230.

Growth hormone supplementation in Turner's Syndrome - Van Vliet G, Deal C. Growth hormone supplementation in Turner's Syndrome. J Pediatr 1998; 133: 803.

The INS 5' VNTR is associated with IGF2 expression in humans - Paquette J, Giannoukakis N, Polychronakos C, Vafiadis P, Deal C. The INS 5' VNTR is associated with IGF2 expression in humans. J Biol Chem 1998; 273: 14158-14164.

Apparent congenital athyreosis contrasting with normal plasma thyroglobulin levels and associated with inactivating mutations in the thyrotropin receptor gene: are athyreosis and ectopic thyroid distinct entities? - Gagné N, Parma J, Deal C, Vassart G, Van Vliet G. Apparent congenital athyreosis contrasting with normal plasma thyroglobulin levels and associated with inactivating mutations in the thyrotropin receptor gene: are athyreosis and ectopic thyroid distinct entities?. J Clin Endocrinol Metab 1998; 83: 1171-1175.

An autosomal dominant form of persistent hyperinsulinemic hypoglycemia of infancy, not linked to the sulfonylurea receptor - Kukuvitis A, Deal C, Arbour L, Polychronakos C. An autosomal dominant form of persistent hyperinsulinemic hypoglycemia of infancy, not linked to the sulfonylurea receptor. J Clin Endocrinol Metab 1997; 82: 1192-1194.

Endocrine therapy in Turner syndrome. (Letter to the editor) - Taback S, Deal C, Van Vliet G. Endocrine therapy in Turner syndrome. (Letter to the editor). N Engl J Med 1997; 336: 1527.

GnRH analogs and the treatment of precocious puberty - Barnes R, Deal C. GnRH analogs and the treatment of precocious puberty. J Soc Obstet Gynecol 1997; 19: 16-26.

Childhood adrenocortical tumors: case series and re-evaluation of prognosis - Mayer S, Oligny L, Deal C, Yazbeck S, Gagné N. Childhood adrenocortical tumors: case series and re-evaluation of prognosis. J Pediatr Surg 1997; 32: 1-3.

Altered mRNA expression due to insertion or substitution of thymine at position +3 or two splice-donor sites in the androgen receptor gene - Trifiro MA, Lumbroso R/Beitel LK, Vasikiou DM, Bouchard J, Deal C, Van Vliet G, Pinsky L. Altered mRNA expression due to insertion or substitution of thymine at position +3 or two splice-donor sites in the androgen receptor gene. Eur J Hum Genet 1997; 5: 50-58.

Brief report: central hypothyroidism caused by inactivating mutations in the thyrotropin-releasing hormone receptor gene - Collu R, Tang J, Castagné J, Lagacé G, Masson N, Huot C, Deal C, Delvin EE, Faccenda E, Eidne K, Van Vliet G. Brief report: central hypothyroidism caused by inactivating mutations in the thyrotropin-releasing hormone receptor gene. J Clin Endocrinol Metab 1997; 82: 1561-1565.

GnRH analogs in the treatment of precocious puberty: state-of-art - Deal C. GnRH analogs in the treatment of precocious puberty: state-of-art. Dans: Proceedings of the 4th International Symposium on GnRH Analogues in Cancer an Human Reproduction. Parthenon Publishing Group Ltd, 1996;.

When Puberty Comes Too Early: A Guide for Canadian Pediatricians - Deal C, . When Puberty Comes Too Early: A Guide for Canadian Pediatricians. Parkurst Publishing Ltd, 1996; .

Precocious Puberty: A Parent's Handbook - Deal C, . Precocious Puberty: A Parent's Handbook. Parkurst Publishing Ltd, 1996; .

Polymorphic functional imprinting of the human IGF2 gene among individuals, in blood cells, is associated with H19 expression - Giannoukakis N, Deal C, Paquette J, Kukuvitis A, Polychronakos C. Polymorphic functional imprinting of the human IGF2 gene among individuals, in blood cells, is associated with H19 expression. Biochem Biophys Res Commun 1996; 220: 1014-1019.

Effects of 14-day infusions of growth hormone (GH) and/or insulin-like growth factor I on the obesity of growing Zucker rats - Dubuis JM, Deal C, Van Vliet G. Effects of 14-day infusions of growth hormone (GH) and/or insulin-like growth factor I on the obesity of growing Zucker rats. Endocrinology 1996; 137: 2799-2806.

Does growth hormone supplementation affect adult height in Turner syndrome? - Taback S, Collu R, Deal C, Guyda HJ, Salisbury S, Dean H, Van Vliet G. Does growth hormone supplementation affect adult height in Turner syndrome?. Lancet 1996; 348: 25-27.

Outcome of severe congenital hypothyroidism: closing the developmental gap with early high dose levothyroxine treatment - Dubuis JM, Glorieux J, Richer F, Deal C, Dussault JH, Van Vliet G. Outcome of severe congenital hypothyroidism: closing the developmental gap with early high dose levothyroxine treatment. J Clin Endocrinol Metab 1996; 81: 222-227.

Mortality in Canadian children with growth hormone (GH) deficiency receiving GH therapy 1967-1992 - Taback S, Dean H, and members of the Canadian Growth Hormone Advisory Committee, Deal C, Van Vliet G. Mortality in Canadian children with growth hormone (GH) deficiency receiving GH therapy 1967-1992. J Clin Endocrinol Metab 1996; 81: 1693-1696.

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