Chercheur

    Linda Booij , Ph.D.

    linda.booij@umontreal.ca
    Linda Booij
    Axe de recherche
    Cerveau et développement de l’enfant
    Thème de recherche
    Développement des psychopathologies
    Adresse
    CHUSJ - Centre de Recherche

    Téléphone
    514 345-4931 #4041

    Fax
    514 345-2176

    Titres

    • Professeur agrégé, Département de Psychologie, Université Concordia
    • Professeur associé, Département de Psychiatrie, Université de Montréal
    • Professeur associé, Département de Psychiatrie, Université McGill

    Formation

    • Stagiaire postdoctorale, Département de Psychiatrie, Université McGill, 2005-2009
    • Ph.D. en Psychologie Clinique, Université de Leiden, Pays-Bas, 2001-2005
    • Maîtrise en méthodologie et statistiques de recherche, Université de Leiden, 1996-2001
    • Maîtrise en psychologie clinique, Université de Leiden, 1997-2000

    Intérêts de recherche

    Mon programme de recherche porte sur des mécanismes neurobiologiques de psychopathologie. Dans le cadre de mes recherches actuelles, j’étudie l’impact de l’adversité vécue en bas âge et des gènes sérotoninergiques sur le développement du système sérotoninergiques et le fonctionnement du système fronto-limbique ainsi que sur le risque de développer des troubles psychologiques.

    Mes autres intérêts de recherche portent sur le rôle de la sérotonine dans le processus émotionnel et dans la vulnérabilité cognitive à la dépression. La méthodologie de recherche que j'utilise s'appuie sur une combinaison d'approches épidémiologiques et d'études expérimentales (neuro-imagerie IRMf, TEP, génétique, épigénétique, mesures comportementales et cognitives).

    Prix et distinctions

    • Instituts de recherche en santé du Canada, Bourse salariale pour nouveau chercheur, 2014-2018
    • Collège Canadien de Neuropsychopharmacologie, Prix jeune chercheur, 2013
    • Narsad- Brain & Behavior Research Foundation – Subvention pour nouveau chercheur, 2013-2015
    • Prix Monique-Gaumond pour jeunes chercheurs travaillant sur le thème de la dépression, 2011
    • Fonds de recherche du Québec-Santé, Chercheur boursier Junior 1, 2011-2015
    • Subvention de recherche. Fondation de H.F. Guggenheim, 2010-2014
    • Fonds projet pilote du réseau de bio-imagerie du Québec, 2010

    Présentations

    • Grand rounds, Dépt. de Psychiatrie, Université Queen’s, Kingston, Canada, avril 2015. The role of Serotonin in psychopathology: Lessons from developmental neuroscience.
    • Cercle d’étude, Faculté de Médecine Dentaire, Université de Montréal, avril 2015. The role of early stress in physical and mental health problems: underlying biological mechanisms and relevance for oral health problems.  
    • Association Ontarienne des services de réadaptation pour enfants (OACRS), Toronto, novembre 2014. Epigenetic mechanisms in child development.
    • Symposium 2014 de la Fondation de la recherche sur le cerveau, Chicago, États-Unis, septembre 2014. What is the current knowledge about chronic physical aggression with respect to both Gene-environment interactions and interventions?
    • 29ième Congrès Mondial de Neuropsychopharmacologie. Vancouver, Canada, juin 2014. Peripheral SLC6A4 methylation: relevance for brain development and risk for depression. Symposium: Serotonin, stress and depression: Genetic and epigenetic factors
    • Congres Mondial “Brain, Behavior and Emotions”, Montréal, avril 2014. Early environmental influences on the development of the brain: role of epigenetic processes and risk for psychopathology.
    • Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre. août 2013. The role of serotonin in mental health problems: lessons from developmental neuroscience
    • Collège Canadien de Neuropsychopharmacologie, mai 2013. Genetic and Early Environmental Influences on the Serotonin System: Consequences for Brain Development and Risk for Mental Illness

    Publications significatives

    • The impact of the in utero and early postnatal environments on grey and white matter volume: A study with adolescent monozygotic twins. Lévesque M, Fahim, C, Ismaylova E, Verner MP, Casey KF, Vitaro F, Brendgen M, Dionne G, Boivin M, Tremblay RE, Booij L. Developmental Neuroscience, Sous presse.
    • The developmental origins of chronic physical aggression: Biological pathways triggered by early life adversity. Provençal N, Booij L, Tremblay RE. The developmental origins of chronic physical aggression: Biological pathways triggered by early life adversity. Journal of Experimental Biology 2015; 218(1): 123-133.
    • Genetic and early environmental influences on the serotonin system: Consequences for brain development and risk for psychopathology.  Booij L, Tremblay RE, Szyf M, Benkelfat C. Genetic and early environmental influences on the serotonin system: Consequences for brain development and risk for psychopathology. Journal of Psychiatry and Neuroscience 2015; 40(1): 5-18.
    • DNA methylation of the serotonin transporter gene in peripheral cells and stress related changes in hippocampal volume: a study in depressed patients and healthy controls. Booij L, Szyf M, Carballedo A, Frey E-M, Morris D, Dimov S, Vaisheva F, Ly V, Fahey C, Meaney J, Gill M, Frodl T. PlosOne, 10(3): e0119061- e0119061.
    • DNA Methylation of serotonin transporter gene (SLC6A4) is associated with brain function involved in processing emotional stimuli. Frodl T, Szyf M, Carballedo A, Ly V, Dymov S, Vaisheva F, Morris D, Fahey C, Meaney J, Gill M, Booij L. (2015). Journal of psychiatry and neuroscience. 31(40(2)): 140180-140180.
    • DNA methylation in individuals with Anorexia Nervosa and in matched normal-eater controls: A genome-wide study. Booij L, Casey K, Antunes J, Szyf M, Israel M, Steiger H. DNA methylation in individuals with Anorexia Nervosa and in matched normal-eater controls: A genome-wide study. International Journal of Eating Disorders, 2015 Mar 23. doi: 10.1002/eat.22374. [Epub ahead of print]
    • Brain serotonin synthesis in MDMA (ecstasy) polydrug users: an α-[11C]-methyl- L-tryptophan study. Booij L, Soucy JP, Young SN, Regoli M, Gravel G, Diksic M, Leyton M, Pihl RO, Benkelfat C. Brain serotonin synthesis in MDMA (ecstasy) polydrug users: an α-[11C]-methyl- L-tryptophan study. Journal of Neurochemistry 2014; 131(5): 634-644.
    • Genome-wide DNA methylation variability in adolescent monozygotic twins followed since birth. Lévesque ML, Casey KF, Szyf M, Ly V, Ismaylova E, Verner MP, Suderman M, Brendgen M, Vitaro F, Boivin M. Tremblay RE, Booij L. (2014). Genome-wide DNA methylation variability in adolescent monozygotic twins followed since birth. Epigenetics 2014; 9(10): 1410-1422.

Publications

Familial liability to psychosis is associated with attenuated dopamine stress signaling in ventromedial prefrontal cortex - Lataster J, Collip D, Ceccarini J, Hernaus D, Haas D, Booij L, van Os J, Pruessner J, Van Laere K, Myin-Germeys I. Familial liability to psychosis is associated with attenuated dopamine stress signaling in ventromedial prefrontal cortex. Schizophr Bull 2014; 40(1): 66-77.

Maturational changes of neonatal electroencephalogram: A comparison between intra uterine and extra uterine development - Nunes ML, Khan R, Gomes Filho I, Booij L, da Costa JC. Maturational changes of neonatal electroencephalogram: A comparison between intra uterine and extra uterine development. Clin Neurophysiol 2014; (sous presse).

Looking beyond the DNA sequence: the relevance of DNA methylation processes for the stress-diathesis model of depression - Booij L, Wang D, Lévesque M, Tremblay RE, Szyf M. Looking beyond the DNA sequence: the relevance of DNA methylation processes for the stress-diathesis model of depression. Philos Trans R Soc Lond B Biol Sci 2013; 368(1615): 20120251.

An 18-year follow-up of seizure outcome after surgery for temporal lobe epilepsy and hippocampal sclerosis. - Hemb M, Palmini A, Paglioli E, Paglioli EB, Costa da Costa J, Azambuja N, Portuguez M, Viuniski V, Booij L, Nunes ML. An 18-year follow-up of seizure outcome after surgery for temporal lobe epilepsy and hippocampal sclerosis.. J Neurol Neurosurg Psychiatry 2013; 84(7): 800-805.

The impact of methylphenidate on seizure frequency and severity in children with attention-deficit-hyperactivity disorder and difficult-to-treat epilepsies - Santos K, Palmini A, Radziuk AL, Rotert R, Bastos F, Booij L, Fernandes BS. The impact of methylphenidate on seizure frequency and severity in children with attention-deficit-hyperactivity disorder and difficult-to-treat epilepsies. Dev Med Child Neurol 2013; 55(7): 654-660.

Stress-induced dopamine release in human medial prefrontal cortex--18F-fallypride/PET study in healthy volunteers - Nagano-Saito A, Dagher A, Booij L, Gravel P, Welfeld K, Casey K, Leyton M, Benkelfat C. Stress-induced dopamine release in human medial prefrontal cortex--18F-fallypride/PET study in healthy volunteers. Synapse 2013; 67(12): 821-830.

Cognitive reactivity, implicit associations, and the incidence of depression: a two-year prospective study - Kruijt AW, Antypa N, Booij L, De Jong PJ, Glashouwer K, Penninx BW, Van der Does W. Cognitive reactivity, implicit associations, and the incidence of depression: a two-year prospective study. PLoS ONE 2013; 8(7): e70245.

COMT Val158Met genotype selectively alters prefrontal [18F]fallypride displacement and subjective feelings of stress in response to a psychosocial stress challenge - Hernaus D, Collip D, Lataster J, Ceccarini J, Kenis G, Booij L, Pruessner J, Van Laere K, van Winkel R, van Os J, Myin-Germeys I. COMT Val158Met genotype selectively alters prefrontal [18F]fallypride displacement and subjective feelings of stress in response to a psychosocial stress challenge. PLoS ONE 2013; 8(6): e65662.

Age-dependent effect of the MAOA gene on childhood physical aggression - Pingault J-B, Côté S, Booij L, Ouellet-Morin I, Castellanos-Ryan N, Vitaro F, Turecki G, Tremblay RE. Age-dependent effect of the MAOA gene on childhood physical aggression. Mol Psychiatry 2013; 18(11): 1151-1152.

Perinatal effects on in vivo measures of brain serotonin synthesis in adulthood: a 27 year longitudinal study - Booij L, Benkelfat C, Leyton M, Vitaro F, Gravel P, Lévesque M, Arseneault L, Diksic M, Tremblay RE. Perinatal effects on in vivo measures of brain serotonin synthesis in adulthood: a 27 year longitudinal study. Eur Neuropsychopharmacol 2012; 22(6): 419-423.

Tryptophan hydroxylase(2) gene polymorphisms predict brain serotonin synthesis in the orbitofrontal cortex in humans - Booij L, Turecki G, Leyton M, Gravel P, Lopez de Lara C, Diksic M, Benkelfat C. Tryptophan hydroxylase(2) gene polymorphisms predict brain serotonin synthesis in the orbitofrontal cortex in humans. Mol Psychiatry 2012; 17(8): 809-817.

Peripheral SLC6A4 DNA methylation is associated with in vivo measures of human brain serotonin synthesis and childhood physical aggression - Wang D, Szyf M, Benkelfat C, Provençal N, Turecki G, Caramaschi D, Côté S, Vitaro F, Tremblay RE, Booij L. Peripheral SLC6A4 DNA methylation is associated with in vivo measures of human brain serotonin synthesis and childhood physical aggression. PLoS ONE 2012; 7(6): e39501.

Genetic and environmental contributions to saliva testosterone levels in male and female infant twins - Caramaschi D, Booij L, Petitclerc A, Boivin M, Tremblay RE. Genetic and environmental contributions to saliva testosterone levels in male and female infant twins. Psychoneuroendocrinology 2012; 37(12): 1954-1959.

Affective regulation of cognitive-control adjustments in remitted depressive patients after acute tryptophan depletion - van Steenbergen H, Booij L, Band GP, Hommel B, Van der Does AJW. Affective regulation of cognitive-control adjustments in remitted depressive patients after acute tryptophan depletion. Cogn Affect Behav Neurosc 2012; 12(2): 280-286.

The effects of MAOA genotype, childhood trauma, and sex on trait and state-dependent aggression - Verhoeven FE, Booij L, Kruijt AW, Cerit H, Antypa N, Does W. The effects of MAOA genotype, childhood trauma, and sex on trait and state-dependent aggression. Brain Behav 2012; 2(6): 806-813.

Altered patterns of brain activity during transient sadness in children at familial risk for major depression - Lévesque M, Beauregard M, Ottenhof KW, Fortier E, Tremblay RE, Brendgen M, Pérusse D, Dionne G, Robaey P, Vitaro F, Boivin M, Booij L. Altered patterns of brain activity during transient sadness in children at familial risk for major depression. J Affect Disord 2011; 135(1-3): 410-413.

Emotional processing as a predictor of symptom change: an acute tryptophan depletion study in depressed patients - Booij L, Van der Does AJW. Emotional processing as a predictor of symptom change: an acute tryptophan depletion study in depressed patients. Eur Neuropsychopharmacol 2011; 21(5): 379-383.

Clinical and physiological correlates of irritability in depression: results from the Netherlands study of depression and anxiety - Verhoeven FE, Booij L, Van der Wee NJ, Penninx BW, Van der Does AJW. Clinical and physiological correlates of irritability in depression: results from the Netherlands study of depression and anxiety. Depress Res Treat 2011; 126895.

Psychosocial stress is associated with in vivo dopamine release in human ventromedial prefrontal cortex: a positron emission tomography study using [18F]fallypride - Lataster J, Collip D, Ceccarini J, Haas D, Booij L, van Os J, Pruessner J, Van Laere K, Myin-Germeys I. Psychosocial stress is associated with in vivo dopamine release in human ventromedial prefrontal cortex: a positron emission tomography study using [18F]fallypride. NeuroImage 2011; 58(4): 1081-1089.

Brain serotonin synthesis in adult males characterized by physical aggression during childhood: a 21-year longitudinal study - Booij L, Tremblay RE, Leyton M, Séguin JR, Vitaro F, Gravel P, Perreau-Linck E, Lévesque M, Durand F, Diksic M, Turecki G, Benkelfat C. Brain serotonin synthesis in adult males characterized by physical aggression during childhood: a 21-year longitudinal study. PLoS ONE 2010; 5(6): e11255 (on line).

Cognitive and serotonergic vulnerability to depression: convergent findings - Booij L, Van der Does AJW. Cognitive and serotonergic vulnerability to depression: convergent findings. J Abnorm Psychol 2007; 116(1): 86-94.

Reduced serotonin synthesis in males with enduring aggressive traits since childhood - Booij L, Tremblay RE, Gravel P, Durand F, Perreau-Linck E, Lévesque M, Leyton M, Séguin JR, Vitaro F, Benkelfat C. Reduced serotonin synthesis in males with enduring aggressive traits since childhood. Neuropharmacology 2006; 31: S12.

Tryptophan depletion affects heart rate variability and impulsivity in remitted depressed patients with a history of suicidal ideation - Booij L, Swenne CA, Brosschot JF, Haffmans PM, Thayer JF, Van der Does AJW. Tryptophan depletion affects heart rate variability and impulsivity in remitted depressed patients with a history of suicidal ideation. Biol Psychiatry 2006; 60(5): 507-514.

Monoamine depletion in psychiatric and healthy populations: review - Booij L, Van der Does AJW, Riedel WJ. Monoamine depletion in psychiatric and healthy populations: review. Mol Psychiatry 2003; 8(12): 951-973.

Predictors of mood response to acute tryptophan depletion: a reanalysis - Booij L, Van der Does AJW, Benkelfat C, Bremner JD, Cowen PJ, Fava M, Gillin C, Leyton M, Moore P, Smith KA, Van der Kloot WA. Predictors of mood response to acute tryptophan depletion: a reanalysis. Neuropsychopharmacology 2002; 27(5): 852-861.

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Créée le 22 juillet 2014
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