Chercheur

    Fernando Alvarez , M.D.

    fernando.alvarez@umontreal.ca
    Fernando Alvarez
    Axe de recherche
    Maladies virales, immunitaires et cancers
    Thème de recherche
    Maladies inflammatoires et de l'immunité: étude des mécanismes physiopathologiques et de l'approche
    Adresse
    CHUSJ Bureau 5700

    Téléphone
    514 345-4626

    Fax
    514 345-4999

    Titres

    • Chef, Service de gastroentérologie, hépatologie et nutrition, CHU Sainte-Justine, Université de Montréal, 2009.
    • Professeur, Département de microbiologie et immunologie, Université de Montréal, 2005.
    • Codirecteur, Unité de pédiatrie interculturelle (anthropologie médicale), CHU Sainte-Justine, Université de Montréal, 2001.
    • Professeur, Service de gastroentérologie, hépatologie et nutrition, CHU Sainte-Justine, Université de Montréal, 1999.
    • Professeur, Département de pédiatrie, Université de Montréal, 1999.
    • Directeur du programme de transplantation hépatique, CHU Sainte-Justine, Université de Montréal, 1995.

    Formation

    • Postdoctorat, Département de biologie cellulaire, Université de New York, 1982-1985.
    • Formation postdoctorale, Unité des maladies hépatiques, Hôpital de Bicêtre, Université de Paris, 1972-1982.
    • Résident en pédiatrie, Hôpital pour enfants, Buenos Aires, 1975-1978.
    • MD, Université de Buenos Aires, 1974.

    Intérêts de recherche

    Constamment exposé aux antigènes alimentaires et aux produits de la flore intestinale, le foie déploie des mécanismes de tolérance immune tout en maintenant sa capacité à élaborer une réponse efficace en cas d’infection. Dans certaines pathologies, telles l’hépatite autoimmune, cette tolérance immunitaire est rompue et, à l’inverse, dans certaines infections virales chroniques telles l’hépatite B et C cette capacité de tolérance peut être nuisible. Notre laboratoire étudie la tolérance immunitaire hépatique à l’aide de modèles murins d’hépatite autoimmune et d’inflammation hépatique causée par une infection virale. Nos travaux actuels porte sur la compréhension des mécanismes immunologiques qui sous-tendent cette tolérance et son bris. À terme, nous visons la mise au point d’immunothérapies précises ciblant les mécanismes de l’homéostase immunitaire hépatique qui permettront la reconstitution d’une tolérance immunitaire ou l’induction d’une réponse immune efficace pour les patients atteints de maladies autoimmunes hépatiques ou d’infections chroniques par les virus B et C de l’hépatite.

    Contributions significatives

    Étude des hépatites virales chez les patients immunosupprimés (étude en cours).

    Développement de modèles animaux d’hépatite autoimmune (J Immunol 2002, Hepatology 2004). Ces modèles permettent l’étude de la pathogenèse de la maladie et l’essai de nouvelles thérapies. Jusqu’à ce jour, ce modèle nous a permis de décrire l’influence des gènes liés ou non au CMH (J Autoimmunity 2006) et de trouver le mécanisme qui sous-tend l’influence de l’âge et du sexe sur le développement de la maladie (Hepatology 2010).

    Développement de nouveaux tests de diagnostic et obtention de deux brevets (J Immuno Methods 2002). Contribution à une meilleure compréhension de la pathogenèse de l'hépatite autoimmune.

    Identification de la formiminotransferase cyclodeaminase comme l'antigène reconnu par les autoanticorps anti-LC1 chez les patients atteints d’hépatite autoimmune de type 2 (Gastroenterology 1999).

    Identification du cytochrome P450 2D6 comme l'antigène reconnu par les autoanticorps microsomes (foie/reins) de type 1 chez les patients atteints de l'hépatite autoimmune de type 2. Caractérisation des localisations de cet antigène (J Exp Med 1985, J Exp Med 1988, Gastroenterology 1988).

    Description de patients atteints d'hépatite autoimmune de type 2 et de l'hépatite C chronique ayant des anticorps LKM1 (Gastroenterology 1993, Eur J Immunology 1993, JPGN 1999) et anti-LC1 dans leur sérum (J Autoimmunity 2004). Identification des mécanismes sous-tendant leur apparition (Hepatology 2005).

    Caractérisation des localisations antigéniques du récepteur de l'asialo-glycoprotéine reconnue par les autoanticorps dans les sérums des patients atteints de l'hépatite autoimmune (Clin Exp Immunol 1998, Eur J Pediatr 2000).

    Mécanismes intracellulaires de la rétention et de la dégradation de l'alpha1-antitrypsine PZ. Ces travaux ont contribué à une meilleure connaissance de la toxicité cellulaire de la carence en alpha1-antitrypsine associée à la mutation Z (FEBS Letters 1999, Eur J Biochem 1993).

    Carence en vitamines A et E : diagnostic et traitement de la cholestase chez l'enfant. Rôle de la vitamine E dans le développement des affections neurologiques. Nos travaux ont permis l'amélioration du suivi offert aux enfants ayant une cholestase chronique. Maintenant, ces enfants reçoivent un traitement systématique en vitamines A et E (Hepatology 1983, Hepatology 1985, JPGN 1984, J Pediatr 1985).

    Culture à long terme des hépatocytes humains et de rat. Ces travaux ont démontré que les hépatocytes en culture primaire peuvent rester dans un état différencié pendant plusieurs mois. Ils ont également permis de décrire certaines conditions nécessaires à l’obtention d’un état différencié (Exp Cell Res 1990, Exp Cell Res 1992, Biol Cell 1994).

    Sommaire de carrière

    Expérience professionnelle

    • Directeur, Département de pédiatrie, Université de Montréal, 2001-2006.
    • Chef, Département de pédiatrie, CHU Sainte-Justine, 2001-2006.

Publications

Humoral immune mechanism of liver injury in giant cell hepatitis with autoimmune hemolytic anemia - Whitington PF, Vos MB, Bass LM, Melin-Aldana H, Romero R, Roy CC, Alvarez F. Humoral immune mechanism of liver injury in giant cell hepatitis with autoimmune hemolytic anemia. J Pediatr Gastroenterol Nutr 2014; 58(1): 74-80.

Neonatal peliosis with maternal ingestion of pesticides - Grzywacz K, Brochu P, Beaunoyer M, Lallier M, Alvarez F. Neonatal peliosis with maternal ingestion of pesticides. J Pediatr Gastroenterol Nutr 2014; 58(2): e14-17.

[Autoimmune hepatitis in children: current perspectives] - Cuarterolo M, Ciocca M, Alvarez F. [Autoimmune hepatitis in children: current perspectives]. Arch Argent Pediatr 2014; 112(2): 169-175.

Low-dose anti-CD3 antibody induces remission of active autoimmune hepatitis in xenoimmunized mice - Marceau G, Yang R, Lapierre P, Béland K, Alvarez F. Low-dose anti-CD3 antibody induces remission of active autoimmune hepatitis in xenoimmunized mice. Liver Int 2014; (sous presse).

A child with unresectable biliary rhabdomyosarcoma: 48-month disease-free survival after liver transplantation - Paganelli M, Beaunoyer M, Samson Y, Bouron-Dal Soglio D, Dubois J, Lallier M, Alvarez F. A child with unresectable biliary rhabdomyosarcoma: 48-month disease-free survival after liver transplantation. Pediatr Transplant 2014; (sous presse).

Torque Teno virus in children who underwent orthotopic liver transplantation: new insights about a common pathogen - Béland K, Dore-Nguyen M, Gagné MJ, Patey N, Brassard J, Alvarez F, Halac U. Torque Teno virus in children who underwent orthotopic liver transplantation: new insights about a common pathogen. J Infect Dis 2014; 209(2): 247-254.

Torque Teno virus load as a biomarker of immunosuppression? New hopes and insights - Béland K, Dore-Nguyen M, Gagné MJ, Patey N, Brassard J, Alvarez F, Halac U. Torque Teno virus load as a biomarker of immunosuppression? New hopes and insights. J Infect Dis 2014; (sous presse).

TTV viral load as a biomarker of immunosuppression? New hopes and insights - Béland K, Dore-Nguyen M, Gagné MJ, Patey N, Brassard J, Alvarez F, Halac U. TTV viral load as a biomarker of immunosuppression? New hopes and insights. J Infect Dis 2014; (sous presse).

Hepatitis E virus seroprevalence before hematopoietic SCT: a pediatric experience - Jaber M, Béland K, Rousseau C, Cellot S, Halac U, Alvarez F, Buteau C. Hepatitis E virus seroprevalence before hematopoietic SCT: a pediatric experience. Bone Marrow Transplant 2014; (sous presse).

Molecular Absorbent Recirculating System therapy (MARS®) in pediatric acute liver failure: a single center experience - Bourgoin P, Mérouani A, Phan V, Litalien C, Lallier M, Alvarez F, Jouvet P. Molecular Absorbent Recirculating System therapy (MARS®) in pediatric acute liver failure: a single center experience. Pediatr Nephrol 2014; 29(5): 901-908.

Is biliary atresia an immune mediated disease? - Alvarez F. Is biliary atresia an immune mediated disease?. J Hepatol 2013; 59(4): 648-650.

Adoptive transfer of ex vivo expanded regulatory T cells in an autoimmune hepatitis murine model restores peripheral tolerance - Lapierre P, Béland K, Yang R, Alvarez F. Adoptive transfer of ex vivo expanded regulatory T cells in an autoimmune hepatitis murine model restores peripheral tolerance. Hepatology 2013; 57(1): 217-227.

Uninsured immigrant and refugee children presenting to Canadian paediatric emergency departments: Disparities in help-seeking and service delivery - Rousseau C, Laurin-Lamothe A, Rummens JA, Meloni F, Steinmetz N, Alvarez F. Uninsured immigrant and refugee children presenting to Canadian paediatric emergency departments: Disparities in help-seeking and service delivery. Pediatr Child Health 2013; 18(9): 465-469.

A liver-specific defect of Acyl-CoA degradation produces hyperammonemia, hypoglycemia and a distinct hepatic Acyl-CoA pattern - Gauthier N, Wu JW, Wang SP, Allard P, Mamer O, Sweetman L, Moser AB, Kratz L, Alvarez F, Robitaille Y, Lépine F, Mitchell GA. A liver-specific defect of Acyl-CoA degradation produces hyperammonemia, hypoglycemia and a distinct hepatic Acyl-CoA pattern. PLoS ONE 2013; 8(7): e60581.

Mouse liver-specific CD8(+) T-cells encounter their cognate antigen and acquire capacity to destroy target hepatocytes - Chabot S, Fakhfakh A, Béland K, Lamarre A, Oldstone MB, Alvarez F, Djilali-Saiah I. Mouse liver-specific CD8(+) T-cells encounter their cognate antigen and acquire capacity to destroy target hepatocytes. J Autoimmun 2013; 42: 19-28.

Portal vein complications after pediatric liver transplantation - Alvarez F. Portal vein complications after pediatric liver transplantation. Curr Gastroenterol Rep 2012; 14(3): 270-274.

Cirrhosis due to chronic hepatitis E infection in a child post-bone marrow transplant - Halac U, Béland K, Lapierre P, Patey N, Ward P, Brassard J, Houde A, Alvarez F. Cirrhosis due to chronic hepatitis E infection in a child post-bone marrow transplant. J Pediatr 2012; 160(5): 871-874.e1.

Effect of nitisinone (NTBC) treatment on the clinical course of hepatorenal tyrosinemia in Québec - Larochelle J, Alvarez F, Bussières J-F, Chevalier I, Dallaire L, Dubois J, Faucher F, Fenyves D, Goodyer P, Grenier A, Holme E, Laframboise R, Lambert MA, Lindstedt S, Maranda B, Melançon S, Merouani A, Mitchell J, Parizeault G, Pelletier L, Phan V, Rinaldo P, Scott C, Scriver C, Mitchell GA. Effect of nitisinone (NTBC) treatment on the clinical course of hepatorenal tyrosinemia in Québec. Mol Genet Metab 2012; 107(1-2): 49-54.

Predictive factors of lamivudine treatment success in an hepatitis B virus-infected pediatric cohort: a 10-year study - Yousef S, Béland K, Mas E, Lapierre P, Bouron-Dal Soglio D, Alvarez F. Predictive factors of lamivudine treatment success in an hepatitis B virus-infected pediatric cohort: a 10-year study. Can J Gastroenterol 2012; 26(7): 429-435.

Liver restores immune homeostasis after local inflammation despite the presence of autoreactive T cells - Béland K, Lapierre P, Djilali-Saiah I, Alvarez F. Liver restores immune homeostasis after local inflammation despite the presence of autoreactive T cells. PLoS ONE 2012; 7(10): e48192.

Chronic hepatitis E infection in children with liver transplantation - Halac U, Béland K, Lapierre P, Patey N, Ward P, Brassard J, Houde A, Alvarez F. Chronic hepatitis E infection in children with liver transplantation. Gut 2012; 61(4): 597-603.

Seronegative hepatitis C virus infection in a child infected via mother-to-child transmission - Larouche A, Gaëtan G, El-Bilali N, Quesnel-Vallières M, Martin S, Alvarez F, Shoukry NH, Soudeyns H. Seronegative hepatitis C virus infection in a child infected via mother-to-child transmission. J Clin Microbiol 2012; 50(7): 2515-2519.

Pharmacokinetic profile of valganciclovir in pediatric transplant recipients - Launay E, Théorêt Y, Litalien C, Duval M, Alvarez F, Lapeyraque AL, Phan V, Larocque D, Poirier N, Lamarre V, Ovetchkine P. Pharmacokinetic profile of valganciclovir in pediatric transplant recipients. Pediatr Infect Dis J 2012; 31(4): 405-407.

Threshold for toxicity from hyperammonemia in critically ill children - Ozanne B, Nelson J, Cousineau J, Lambert MA, Phan V, Mitchell GA, Alvarez F, Ducruet T, Jouvet P. Threshold for toxicity from hyperammonemia in critically ill children. J Hepatol 2012; 56(1): 123-128.

Outcomes in children who underwent transplantation for autoimmune hepatitis - Martin S, Alvarez F, Anand R, Song C, Yin W, SPLIT Research Group. Outcomes in children who underwent transplantation for autoimmune hepatitis. Liver Transpl 2011; 17(4): 393-401.

Description of two new ABCB11 mutations responsible for type 2 benign recurrent intrahepatic cholestasis in a French-Canadian family - Beauséjour Y, Alvarez F, Beaulieu M, Bilodeau M. Description of two new ABCB11 mutations responsible for type 2 benign recurrent intrahepatic cholestasis in a French-Canadian family. Can J Gastroenterol 2011; 25(6): 311-314.

Different sites of xenoantigen delivery lead to a virally induced late-onset hepatitis in mice through molecular mimicry - Piché C, Béland K, Lapierre P, Massie B, Alvarez F. Different sites of xenoantigen delivery lead to a virally induced late-onset hepatitis in mice through molecular mimicry. Liver Int 2011; 31(9): 1306-1314.

Hyperammonemia and neonatal cardiac failure - Adamovic T, Jouvet P, Vobecky S, Garel L, Rougemont A-L, Alvarez F. Hyperammonemia and neonatal cardiac failure. Minerva Anestesiol 2011; 77(5): 554-557.

Structural basis for broad neutralization of hepatitis C virus quasispecies - Lapierre P, Troesch M, Alvarez F, Soudeyns H. Structural basis for broad neutralization of hepatitis C virus quasispecies. PLoS ONE 2011; (10): e26981.

Deficiency of liver adipose triglyceride lipase in mice causes progressive hepatic steatosis - Wu J, Wang SP, Alvarez F, Casavant S, Gauthier N, Abel L, Soni K, Yang G, Mitchell GA. Deficiency of liver adipose triglyceride lipase in mice causes progressive hepatic steatosis. Hepatology 2011; 54(1): 122-132.

Limited sampling strategies for monitoring tacrolimus in pediatric liver transplant recipients - Delaloye JR, Kassir N, Lapeyraque AL, Alvarez F, Lallier M, Beaunoyer M, Labbe L, Théorêt Y, Litalien C. Limited sampling strategies for monitoring tacrolimus in pediatric liver transplant recipients. Therap Drug Monit 2011; 33(4): 380-386.

Forkhead box p3(+) regulatory T cell underlies male resistance to experimental type 2 autoimmune hepatitis - Lapierre P, Béland K, Martin C, Alvarez F Jr, Alvarez F. Forkhead box p3(+) regulatory T cell underlies male resistance to experimental type 2 autoimmune hepatitis. Hepatology 2010; 51(5): 1789-1798.

Pédiatrie et obésité: un conflit entre nature et culture, coll. Intervenir - Alvarez F, Levy E, Roy M, e. Pédiatrie et obésité: un conflit entre nature et culture, coll. Intervenir. Éditions du CHU Sainte-Justine, 2010; 208 pages.

Hépatite auto-immune - Alvarez F. Hépatite auto-immune. Dans: Cochat P (ed.). Maladies du foie et des voiles biliaires chez l'enfant, no 27. Collection Progrès en pédiatrie. France. Doin Éditeurs, 2010; 167-177.

Stéatose hépatique, NASH et nutrition - Peretti N, Alvarez F. Stéatose hépatique, NASH et nutrition. Dans: Cochat P (ed.). Maladies du foie et des voiles biliaires chez l'enfant, no 27. Collection Progrès en pédiatrie. France. Doin Éditeurs, 2010; 229-242.

[Portal hypertension in pediatrics: II: Hemorrhagic complications] - Costaguta A, Alvarez F. [Portal hypertension in pediatrics: II: Hemorrhagic complications]. Arch Argent Pediatr 2010; 108(4): 337-342.

[Portal hypertension in pediatrics. I: pathophysiology and clinical aspects] - Costaguta A, Alvarez F. [Portal hypertension in pediatrics. I: pathophysiology and clinical aspects]. Arch Argent Pediatr 2010; 108(4): 239-242.

Unusual association between autoimmune hepatitis and severe pyoderma gangrenosum - Halac U, Al Dhaybi R, Powell J, Bouron-Dal Soglio D, Alvarez F. Unusual association between autoimmune hepatitis and severe pyoderma gangrenosum. J Pediatr Gastroenterol Nutr 2010; 50(2): 219-221.

Systemic progression of type IV glycogen storage disease after liver transplantation - Willot S, Marchand V, Rasquin A, Alvarez F, Martin S. Systemic progression of type IV glycogen storage disease after liver transplantation. J Pediatr Gastroenterol Nutr 2010; 51(5): 661-664.

[Genetic cholestasis] - Ciocca M, Alvarez F. [Genetic cholestasis]. Arch Argent Pediatr 2009; 107(4): 340-346.

Hepatitis: new hope for difficult cases of autoimmune hepatitis - Halac U, Alvarez F. Hepatitis: new hope for difficult cases of autoimmune hepatitis. Nat Rev Gastroenterol Hepatol 2009; 6(11): 629-630.

[Pediatric practice in a pluricultural setting: an ongoing experience] - Alvarez F, Fortin S, Bibeau G. [Pediatric practice in a pluricultural setting: an ongoing experience]. Arch Argent Pediatr 2008; 106(3): 236-241.

Contemporary medicine: Applied human science or technological enterprise? - Fortin S, Alvarez F, Bibeau G, Laudy D. Contemporary medicine: Applied human science or technological enterprise?. Ethics & Medicine 2008; 24(1): 41-50.

Prognostic factors in paediatric acute liver failure - Ciocca M, Ramonet M, Cuarterolo M, Lopez S, Cernadas C, Alvarez F. Prognostic factors in paediatric acute liver failure. Arch Dis Child 2008; 93(1): 48-51.

Massive hematuria due to portal hypertension in a child with bladder augmentation for vesical exstrophy - Lipsich J, Rojas LM, Alonso J, Teplisky D, Halac A, Alvarez F, Sierre S. Massive hematuria due to portal hypertension in a child with bladder augmentation for vesical exstrophy. J Pediatr Urol 2008; 4(3): 236-238.

Interface hepatitis is associated with a high incidence of late graft fibrosis in a group of tightly monitored pediatric orthotopic liver transplantation patients - Herzog D, Soglio DB, Fournet JC, Martin S, Marleau D, Alvarez F. Interface hepatitis is associated with a high incidence of late graft fibrosis in a group of tightly monitored pediatric orthotopic liver transplantation patients. Liver Transpl 2008; 14(7): 946-955.

An immunohistochemical evaluation of C4d deposition in pediatric inflammatory liver diseases - Bouron-Dal Soglio D, Rougemont A-L, Herzog D, Soucy G, Alvarez F, Fournet JC. An immunohistochemical evaluation of C4d deposition in pediatric inflammatory liver diseases. Hum Pathol 2008; 39(7): 1103-1110.

Tyrosinemia - Mitchell GA, Alvarez F, Dubois J, Russo P. Tyrosinemia. Dans: Suchy FJ, Sokol R, Baliestreri W (eds). Liver Disease in Childhood - 3e édition. Cambridge. Cambridge University Press, 2007; 694-713.

Insuffisance hépatique aiguë - Durand P, Alvarez F, de Jaegger A, Devictor D. Insuffisance hépatique aiguë. Dans: Lacroix J, Gauthier M, Hubert P, Leclerc F, Gaudreault P (eds). Urgences et soins intensifs pédiatriques. Montréal et Paris. Éditions du CHU Sainte-Justine et Elsevier Masson, 2007; 685-703.

Le foie: un organe du système immunitaire? - Lapierre P, Alvarez F. Le foie: un organe du système immunitaire?. Médecine Sciences 2007; 23(11): 985-990.

Hépatite virale - Carceller A, Alvarez F, Tapiero B. Hépatite virale. Dans: Turgeon J, Bernard-Bonnin AC, Gervais P, Ovetchkine P, Gauthier M (eds). Dictionnaire de thérapeutique pédiatrique Weber, 2e édition. Boucherville. Gaëtan Morin, 2007; 603-609.

Ictère - Carceller A, Alvarez F, Teasdale F. Ictère. Dans: Turgeon J, Bernard-Bonnin AC, Gervais P, Ovetchkine P, Gauthier M (eds). Dictionnaire de thérapeutique pédiatrique Weber, 2e édition. Boucherville. Gaëtan Morin, 2007; 663-673.

Insuffisance hépatique aiguë - Jouvet P, Alvarez F. Insuffisance hépatique aiguë. Dans: Turgeon J, Bernard-Bonnin AC, Gervais P, Ovetchkine P, Gauthier M (eds). Dictionnaire de thérapeutique pédiatrique Weber, 2e édition. Boucherville. Gaëtan Morin, 2007; 739-744.

Billiary atresia: the Canadian experience - Schreiber RA, Barker CC, Roberts EA, Martin S, Alvarez F, Smith L, Butzner D, Wrobel I, Mack D, Moroz S, Rashid M, Persad R, Lévesque D, Brill H, Bruce G, Critch J. Billiary atresia: the Canadian experience. J Pediatr 2007; 151(6): 659-665.

Mesangiolipidosis in Alagille syndrome--relationship with apolipoprotein A-I - Benoit G, Sartelet H, Levy E, Boule ME, Alvarez F, Abed L, Mérouani A. Mesangiolipidosis in Alagille syndrome--relationship with apolipoprotein A-I. Nephrol Dial Transpl 2007; 22(7): 2072-2075.

Pathogenesis of autoimmune hepatitis: from break of tolerance to immune-mediated hepatocyte apoptosis - Lapierre P, Béland K, Alvarez F. Pathogenesis of autoimmune hepatitis: from break of tolerance to immune-mediated hepatocyte apoptosis. Transl Res 2007; 149(3): 107-113.

Abnormal hepatobiliary and circulating lipid metabolism in the Long-Evans Cinnamon rat model of Wilson's disease - Levy E, Brunet S, Alvarez F, Seidman EG, Bouchard G, Escobar E, Martin S. Abnormal hepatobiliary and circulating lipid metabolism in the Long-Evans Cinnamon rat model of Wilson's disease. Life Sci 2007; 80(16): 1472-1483.

Type 2 autoimmune hepatitis murine model: the influence of genetic background in disease development - Lapierre P, Béland K, Djilali-Saiah I, Alvarez F. Type 2 autoimmune hepatitis murine model: the influence of genetic background in disease development. J Autoimmun 2006; 26(2): 82-89.

Risk of portal obstruction in newborns - Alvarez F. Risk of portal obstruction in newborns. J Pediatr 2006; 148(6): 715-716.

Autoimmune hepatitis and primary sclerosing cholangitis - Alvarez F. Autoimmune hepatitis and primary sclerosing cholangitis. Dans: Gitlin N (ed). Clinics in Liver Disease. Elsevier Saunders, 2006; 89-107.

Transplantation d'organes: enjeux éthiques et sociaux - Alvarez F. Transplantation d'organes: enjeux éthiques et sociaux. Dans: De Plaen S (ed). La transplantation d'organes: enjeux et paradoxes. Collection Intervenir. Montréal, Qc. Éditions de l'Hôpital Sainte-Justine, 2006; 13-23.

Intrahepatic biliary cysts presenting before hepatic portoenterostomy in biliary atresia - Mas E, Alvarez F, Oligny LL, Martin S. Intrahepatic biliary cysts presenting before hepatic portoenterostomy in biliary atresia. J Pediatr Gastroenterol Nutr 2006; 42(2): 440-442.

Obituary for daniel Alagille - Roy CC, Alvarez F, Richard G. Obituary for daniel Alagille. J Pediatr Gastroenterol Nutr 2006; 42(2): 127-128.

Study of a novel hypervariable region in hepatitis C virus (HCV) E2 envelope glycoprotein - Troesch M, Meunier I, Lapierre P, Lapointe N, Alvarez F, Boucher M, Soudeyns H. Study of a novel hypervariable region in hepatitis C virus (HCV) E2 envelope glycoprotein. Virology 2006; 352(2): 357-367.

HLA class II influences humoral autoimmunity in patients with type 2 autoimmune hepatitis - Djilali-Saiah I, Fakhfakh A, Louafi H, Caillat-Zucman S, Debray D, Alvarez F. HLA class II influences humoral autoimmunity in patients with type 2 autoimmune hepatitis. J Hepatol 2006; 45(6): 844-850.

Liver transplantation for cirrhosis in cystic fibrosis - Lamireau T, Martin S, Lallier M, Marcotte J-É, Alvarez F. Liver transplantation for cirrhosis in cystic fibrosis. Can J Gastroenterol 2006; 20(7): 475-478.

Cleavage of intracellular hepatitis C RNA in the virus core protein region by deoxyribozymes - Trépanier J, Tanner J, Momparler RL, Le NLO, Alvarez F, Alfieri C. Cleavage of intracellular hepatitis C RNA in the virus core protein region by deoxyribozymes. J Viral Hepat 2006; 13(2): 131-138.

Normal glomerular filtration rate in long-term follow-up of children after orthotopic liver transplantation - Herzog D, Martin S, Turpin S, Alvarez F. Normal glomerular filtration rate in long-term follow-up of children after orthotopic liver transplantation. Transplantation 2006; 81(5): 672-677.

Hepatocyte transplantation in the Long Evans Cinnamon rat model of Wilson's Disease - Park SM, Vo K, Lallier M, Cloutier A, Brochu P, Alvarez F, Martin S. Hepatocyte transplantation in the Long Evans Cinnamon rat model of Wilson's Disease. Cell Transplant 2006; 15(1): 13-22.

Follow-up of children with autoimmune hepatitis treated with cyclosporine - Cuarterolo M, Ciocca M, Velasco CC, Ramonet M, Gonzales M, Lopez S, Garsd A, Alvarez F. Follow-up of children with autoimmune hepatitis treated with cyclosporine. J Pediatr Gastroenterol Nutr 2006; 43(5): 635-639.

LKM1 autoantibodies in chronic hepatitis C infection : a case of molecular mimicry? - Marceau G, Lapierre P, Soudeyns H, Alvarez F. LKM1 autoantibodies in chronic hepatitis C infection : a case of molecular mimicry?. Hepatology 2005; 42(3): 675-682.

Autoimmune hepatitis in children: clinical and diagnostic aspects - Alvarez F. Autoimmune hepatitis in children: clinical and diagnostic aspects. Dans: Dienes H-P, Leuschner U, Lohse AW, Manns MP (eds). Autoimmune Liver Disease. Germany. Springer and Falk Foundation, 2005; 271-277.

Cyclosporin indication in "autoimmune hepatitis" - Alvarez F. Cyclosporin indication in "autoimmune hepatitis". Dans: Dienes H-P, Leuschner U, Lohse AW, Manns MP (eds). Autoimmune Liver Disease. Germany. Springer and Falk Foundation, 2005; 294-297.

Neonatal cholestasis associated with fetal arrhythmia - Sant'Anna A, Fouron J-C, Alvarez F. Neonatal cholestasis associated with fetal arrhythmia. J Pediatr 2005; 146(2): 277-280.

Reduced bile flow associated with parenteral nutrition is independent of oxidant load and parenteral multivitamins - Lavoie JC, Chessex P, Gauthier C, Levy E, Alvarez F, St-Louis P, Rouleau T. Reduced bile flow associated with parenteral nutrition is independent of oxidant load and parenteral multivitamins. J Pediatr Gastroenterol Nutr 2005; 41(1): 108-114.

Ascites after orthotopic liver transplantation in children - Herzog D, Lallier M, Martin S, Alvarez F. Ascites after orthotopic liver transplantation in children. Pediatr Transplant 2005; 9(1): 74-79.

A murine model of type 2 autoimmune hepatitis: Xenoimmunization with human antigens - Lapierre P, Djilali-Saiah I, Vitozzi S, Alvarez F. A murine model of type 2 autoimmune hepatitis: Xenoimmunization with human antigens. Hepatology 2004; 39(4): 1066-1074.

Treatment of autoimmune hepatitis: current and future therapies - Alvarez F. Treatment of autoimmune hepatitis: current and future therapies. Curr Treat Options Gastroenterol 2004; 7(5): 413-420.

Liver autoimmune serology: a consensus statement from the committee for autoimmune serology of the International Autoimmune Hepatitis Group - Vergani D, Alvarez F, Bianchi FB, Cancado EL, Mackay IR, Manns MP, Nishioka M, Penner E. Liver autoimmune serology: a consensus statement from the committee for autoimmune serology of the International Autoimmune Hepatitis Group. J Hepatol 2004; 41: 677-683.

Role of NK and NKT cells in the immunopathogenesis of HCV-induced hepatitis load - Ahmad A, Alvarez F. Role of NK and NKT cells in the immunopathogenesis of HCV-induced hepatitis load. J Leukoc Biol 2004; 76(4): 743-759.

Anti-LC1 autoantibodies in patients with chronic hepatitis C virus infection - Béland K, Lapierre P, Marceau G, Alvarez F. Anti-LC1 autoantibodies in patients with chronic hepatitis C virus infection. J Autoimmun 2004; 22(2): 159-166.

Linkage disequilibrium between HLA class II region and autoimmune hepatitis in pediatric patients - Djilali-Saiah I, Renous R, Caillat-Zucman S, Debray D, Alvarez F. Linkage disequilibrium between HLA class II region and autoimmune hepatitis in pediatric patients. J Hepatol 2004; 40(6): 904-909.

Anti-soluble liver antigen (SLA) antibodies in chronic HCV infection - Vitozzi S, Lapierre P, Djilali-Saiah I, Marceau G, Béland K, Alvarez F. Anti-soluble liver antigen (SLA) antibodies in chronic HCV infection. Autoimmunity 2004; 37(3): 217-222.

Pharmacokinetics of omeprazole in healthy adults and in children with gastroesophageal reflux disease - Marier JF, Dubuc MC, Drouin E, Alvarez F, Ducharme MP, Brazier J-L. Pharmacokinetics of omeprazole in healthy adults and in children with gastroesophageal reflux disease. Therap Drug Monit 2004; 26(1): 3-8.

Characterization of the antigenicity of the formiminotransferase-cyclodeaminase in type 2 autoimmune hepatitis - Renous R, Lapierre P, Djilali-Saiah I, Vitozzi S, Alvarez F. Characterization of the antigenicity of the formiminotransferase-cyclodeaminase in type 2 autoimmune hepatitis. Exp Cell Res 2004; 292(2): 332-341.

Epidemiology of liver disease in cystic fibrosis: a longitudinal study - Lamireau T, Monnereau S, Martin S, Marcotte J-É, Winnock M, Alvarez F. Epidemiology of liver disease in cystic fibrosis: a longitudinal study. J Hepatol 2004; 41: 920-925.

Transient cholestasis in newborn infants with perinatal asphyxia - Herzog D, Chessex P, Martin S, Alvarez F. Transient cholestasis in newborn infants with perinatal asphyxia. Can J Gastroenterol 2003; 17(3): 179-182.

Characterization of the B cell response of patients with anti-liver cytosol autoantibodies in type 2 autoimmune hepatitis - Lapierre P, Johanet C, Alvarez F. Characterization of the B cell response of patients with anti-liver cytosol autoantibodies in type 2 autoimmune hepatitis. Eur J Immunol 2003; 33(7): 1869-1878.

Epstein-Barr virus early-antigen serologic testing in conjunction with peripheral blood EBV DNA load as a marker for risk of posttransplantation lymphoproliferative disease - Carpentier L, Tapiero B, Alvarez F, Viau C, Alfieri C. Epstein-Barr virus early-antigen serologic testing in conjunction with peripheral blood EBV DNA load as a marker for risk of posttransplantation lymphoproliferative disease. J Infect Dis 2003; 188(12): 1853-1864.

Hepatic artery pseudoaneurysm following laparoscopic cholecystectomy - Chigot V, Lallier M, Alvarez F, Dubois J. Hepatic artery pseudoaneurysm following laparoscopic cholecystectomy. Pediatr Radiol 2003; 33: 24-26.

DNA vaccination breaks tolerance for a neo-self antigen in liver : a transgenic murine model of autoimmune hepatitis - Djilali-Saiah I, Lapierre P, Vitozzi S, Alvarez F. DNA vaccination breaks tolerance for a neo-self antigen in liver : a transgenic murine model of autoimmune hepatitis. J Immunol 2002; 169: 4889-4896.

Immune diseases of the liver and biliary tract - Alvarez F, Schwarz KB. Immune diseases of the liver and biliary tract. J Pediatr Gastroenterol Nutr 2002; 35(1): 539-543.

Post-transplant lymphoproliferative disorders : Making sense of the proliferation of potential therapies - Alvarez F. Post-transplant lymphoproliferative disorders : Making sense of the proliferation of potential therapies. J Pediatr Gastroenterol Nutr 2002; 34: 359-361.

Autoimmune enteropathy: A review - Russo P, Alvarez F. Autoimmune enteropathy: A review. Clin Applied Immunol Rev 2002; 2: 203-216.

Anti-soluble liver antigen/liver-pancreas (SLA/LP) Antibodies in pediatric patients with autoimmune hepatitis - Vitozzi S, Djilali-Saiah I, Lapierre P, Alvarez F. Anti-soluble liver antigen/liver-pancreas (SLA/LP) Antibodies in pediatric patients with autoimmune hepatitis. Autoimmunity 2002; 35: 485-492.

Hepatitis autoinmune. Tratamiento con ciclosporina - Cuarterolo M, Ciocca M, Lopez S, de Davila MTG, Roy A, Alvarez F. Hepatitis autoinmune. Tratamiento con ciclosporina. Medicina Infantil 2002; IX: 104-108.

Photooxidation of parenteral multivitamins induces hepatic steatosis in a neonatal guinea pig model of intravenous nutrition - Chessex P, Lavoie JC, Rouleau T, Brochu P, St-Louis P, Levy E, Alvarez F. Photooxidation of parenteral multivitamins induces hepatic steatosis in a neonatal guinea pig model of intravenous nutrition. Pediatr Res 2002; 52(6): 958-963.

Autoantibody detection in type 2 autoimmune hepatitis using a chimera recombinant protein - Vitozzi S, Lapierre P, Djilali-Saiah I, Alvarez F. Autoantibody detection in type 2 autoimmune hepatitis using a chimera recombinant protein. J Immunol Methods 2002; 262: 103-110.

Hepatic insufficiency and liver transplantation in a patient with COACH syndrome - Herzog D, Martin S, Yandza T, Alvarez F. Hepatic insufficiency and liver transplantation in a patient with COACH syndrome. Pediatr Transplant 2002; 6(5): 443-446.

Long term follow-up of chronic hepatitis B virus infection in children of different ethnic origin - Marx G, Martin S, Chicoine JF, Alvarez F. Long term follow-up of chronic hepatitis B virus infection in children of different ethnic origin. J Infect Dis 2002; 186(3): 295-301.

Centrilobular fibrosis in long-term follow-up of pediatric liver transplant recipients - Martin S, Russo P, Dubois J, Alvarez F. Centrilobular fibrosis in long-term follow-up of pediatric liver transplant recipients. Transplantation 2002; 74(6): 828-836.

Nonalcoholic fatty liver disease (NAFLD) in children - Pushpa S, Martin S, Alvarez F. Nonalcoholic fatty liver disease (NAFLD) in children. Curr Opin Pediatr 2002; 14: 593-600.

Autoimmune hepatitis - Alvarez F. Autoimmune hepatitis. Dans: Suchy FJ, Sokol R, Baliestreri W (eds). Liver Disease in Chilhood - 2ème édition. St-Louis. Mosby, 2001; 429-441.

Tyrosinemia - Mitchell GA, Alvarez F, Dubois J, Russo P. Tyrosinemia. Dans: Suchy FJ, Sokol R, Baliestreri W (eds). Liver Disease in Chilhood - 2ème édition. St-Louis. Mosby, 2001; 667-686.

Impact of chronic hepatitis B virus disease and interferon alpha therapy on growth of children - Comanor L, Minor J, Conjeevaram HS, Roberts EA, Alvarez F, Bern EM, Goyens P, Rosenthal P, Lachaux A, Shelton M, Sarles J, Sokal EM. Impact of chronic hepatitis B virus disease and interferon alpha therapy on growth of children. J Viral Hepat 2001; 8: 139-147.

CTLA-4/CD28 region polymorphisms in children from families with autoimmune hepatitis - Djilali-Saiah I, Ouellette P, Caillat-Zucman S, Debray D, Kohn JI, Alvarez F. CTLA-4/CD28 region polymorphisms in children from families with autoimmune hepatitis. Hum Immunol 2001; 62: 1356-1362.

Primary non-Hodgkin lymphoma of the extrahepatic biliary tract and gallbladder in a child - Gravel J, Lallier M, Garel L, Brochu P, Champagne J, Alvarez F. Primary non-Hodgkin lymphoma of the extrahepatic biliary tract and gallbladder in a child. J Pediatr Gastroenterol Nutr 2001; 32(5): 598-601.

Immune diseases of the liver and biliary tract - Alvarez F, Schwarz KB. Immune diseases of the liver and biliary tract. Dans: Sokol R (ed). Pediatric Liver Research Agenda 2000 : A Blueprint for the futur. New York. The American Liver Foundation, 2000; 73-78.

Autoimmune hepatitis in children - Alvarez F. Autoimmune hepatitis in children. Dans: Falk Symposium No. 114 " Immunology and Liver . Suisse. Kluwer academic publishers, 2000; 93-98.

NOF-11: A one-year pediatric randomized double-blind comparison of neoral versus sandimmune in orthotopic liver transplantation - Alvarez F, Atkinson P, Grant D, Guibaud L, Jones A, Kim P, Kneteman N, Laurin L, Martin S, Murphy G, Paradis K, Shapiro J, Smith LJ, Superina R. NOF-11: A one-year pediatric randomized double-blind comparison of neoral versus sandimmune in orthotopic liver transplantation. Transplantation 2000; 69: 87-92.

Autoantibodies in recent onset type-1 diabetic patients to a Mr 60K microsomal hepatic protein : new evidence for autoantibodies to the type-2 glucose transporter - Pehuet-Figoni M, Alvarez F, Bach J-F, Chatenoud L. Autoantibodies in recent onset type-1 diabetic patients to a Mr 60K microsomal hepatic protein : new evidence for autoantibodies to the type-2 glucose transporter. Clin Exp Immunol 2000; 122: 164-169.

Past and future of biliary atresia - Carceller A, Blanchard H, Alvarez F, St-Vil D, Bensoussan A, Di Lorenzo M. Past and future of biliary atresia. J Pediatr Surg 2000; 35(5): 717-720.

Autoantibodies to the asialoglycoprotein receptor in sera children with autoimmune hepatitis - Hajoui O, Debray D, Martin S, Alvarez F. Autoantibodies to the asialoglycoprotein receptor in sera children with autoimmune hepatitis. Eur J Pediatr 2000; 159: 310-313.

Statistical models for predicting response to interferon-alpha and spontaneous seroconversion in children with chronic hepatitis B - Comanor L, Minor J, Conjeevaram HS, Roberts EA, Alvarez F, Bern EM, Goyens P, Rosenthal P, Lachaux A, Shelton M, Sarles J, Sokal EM. Statistical models for predicting response to interferon-alpha and spontaneous seroconversion in children with chronic hepatitis B. J Viral Hepat 2000; 7: 144-152.

International Autoimmune Hepatis Group Report: Review of criteria for diagnosis of autoimmune hepatitis - Alvarez F, Berg PA, Bianchi L, Burroughs AK, Cancado EL, Chapman AB, Cooksley W, Czaja AJ, Desmet VJ, Donaldson PT, Eddleston A, et al. International Autoimmune Hepatis Group Report: Review of criteria for diagnosis of autoimmune hepatitis. J Hepatol 1999; 31: 929-938.

Short term cyclosporine induces a remission of autoimmune hepatitis in children - Alvarez F, Ciocca M, Canero-Velasco C, Ramonet M, de Davila MTG, Cuarterolo M, Gonzalez T, Jara-Vega P, Camarena C, Brochu P, Drut R, Alvarez E. Short term cyclosporine induces a remission of autoimmune hepatitis in children. J Hepatol 1999; 30: 222-227.

Accuracy of the 13C urea breath test to diagnose helicobacter pylori gastritis in pediatric patients - Delvin EE, Brazier J-L, Deslandres C, Alvarez F, Russo P, Seidman EG. Accuracy of the 13C urea breath test to diagnose helicobacter pylori gastritis in pediatric patients . J Pediatr Gastroenterol Nutr 1999; 28: 59-62.

Severe autoimmune polyendocrinopathy-Candidiasis-Ectodermal dystrophy in an adolescent girl with a novel AIRE mutation: Response to immunosuppressive therapy - Ward L, Paquette J, Seidman EG, Huot C, Alvarez F, Crock P, Delvin EE, Kampe O, Deal C. Severe autoimmune polyendocrinopathy-Candidiasis-Ectodermal dystrophy in an adolescent girl with a novel AIRE mutation: Response to immunosuppressive therapy. J Clin Endocrinol Metab 1999; 84: 844-852.

Formiminotransferase cyclodeaminase in an organ specific autoantigene recognized by sera of autoimmune hepatitis patients - Lapierre P, Hajoui O, Homberg J-C, Alvarez F. Formiminotransferase cyclodeaminase in an organ specific autoantigene recognized by sera of autoimmune hepatitis patients. Gastroenterology 1999; 116: 643-649.

Sera of children with hepatitis C infection and anti-liver-kidney microsome-1 antibodies recognize different CYP2D6 epitopes than adults with LKM+/HCV+ sera - Herzog D, Yamamoto AM, Jara-Vega P, Maggiore G, Sarles J, Alvarez F. Sera of children with hepatitis C infection and anti-liver-kidney microsome-1 antibodies recognize different CYP2D6 epitopes than adults with LKM+/HCV+ sera. J Pediatr Gastroenterol Nutr 1999; 29(5): 551-555.

A case of non A, non B, non C hepatitis that relapsed into fulminant hepatic failure - Cuffari C, Brochu P, Alvarez F. A case of non A, non B, non C hepatitis that relapsed into fulminant hepatic failure. Hepatogastroenterology 1998; 45: 2348-2351.

Interferon Alfa therapy for chronic hepatitis B in children: A multinational randomized controlled trial - Sokal EM, Conjeevaram HS, Roberts EA, Alvarez F, Bern EM, Goyens P, Rosenthal D, Lachaud A, Shelton M, Sarles J, Hoofnagle J. Interferon Alfa therapy for chronic hepatitis B in children: A multinational randomized controlled trial. Gastroenterology 1998; 114: 988-995.

Study of antigenic sites on the asialoglycoprotein receptor recognized by autoantibodies - Hajoui O, Martin S, Alvarez F. Study of antigenic sites on the asialoglycoprotein receptor recognized by autoantibodies. Clin Exp Immunol 1998; 113: 339-345.

Cyclosporine monotherapy in long term pediatric transplant recipients - Martin S, Paradis K, Alvarez F. Cyclosporine monotherapy in long term pediatric transplant recipients. Transplant Proc 1998; 30: 1424-1427.

MHC class II sequences of susceptibility and protection in Mexicans with autoimmune hepatitis - Vazquez-Garcia MN, Alaez C, Olivo A, Debaz H, Pérez-Luque E, Canos S, Burquete A, de la Rosa G, Autista N, Hernandez A, Bandera J, Kershenobich D, Alvarez F, Gorodezky C. MHC class II sequences of susceptibility and protection in Mexicans with autoimmune hepatitis. J Hepatol 1998; 28: 985-990.

Long term treatment of bleeding caused by portal hypertension in children - Alvarez F. Long term treatment of bleeding caused by portal hypertension in children. J Pediatr 1997; 131: 798-800.

Acute intrahepatic portal vein thrombosis complicating cholangitis in biliary atresia - Cuffari C, Seidman EG, Dubois J, Brochu P, Alvarez F. Acute intrahepatic portal vein thrombosis complicating cholangitis in biliary atresia. Eur J Pediatr 1997; 156: 186-189.

Study of immune reactivity of a minocycline induced chronic active hepatitis - Herzog D, Hajoui O, Russo P, Alvarez F. Study of immune reactivity of a minocycline induced chronic active hepatitis. Dig Dis Sci 1997; 42: 1100-1103.

A new approach to cytochrome CYP2D6 antibody detection in autoimmune hepatitis type 2 and chronic hepatitis C virus infection: a sensitive and quantitative radioligand assay - Yamamoto AM, Johanet C, Bustarret F, Duclos-Vallée J-C, Alvarez F, Homberg J-C, Bach J-F. A new approach to cytochrome CYP2D6 antibody detection in autoimmune hepatitis type 2 and chronic hepatitis C virus infection: a sensitive and quantitative radioligand assay. Clin Exp Immunol 1997; 108: 396-400.

Subfulminant hepatic failure in autoimmune hepatitis type 1: an unusual form of presentation - Herzog D, Rasquin A, Debray D, Alvarez F. Subfulminant hepatic failure in autoimmune hepatitis type 1: an unusual form of presentation. J Hepatol 1997; 27: 578-582.

Les hépatites chroniques associées aux anticorps anti-microsomes de foie et de rein (anti-LKM) - Duclos-Vallée J-C, Yamamoto AM, Buffet C, Alvarez F. Les hépatites chroniques associées aux anticorps anti-microsomes de foie et de rein (anti-LKM). Hepatogastroenterology 1997; 4: 189-194.

HLA and autoimmune hepatitis: 12th International Histocompatibility workshop study - Fainboim L, Pando M, Larriba J, Goldberg AC, Gorodezky C, Fainboim H, Ciocca M, Ramonet M, Badia I, Galoppo C, Fernandez GC, Lindel N, Capuchio M, Findor J, Darnich J, Vazquez MN, Alaez C, de la Rosa G, Badera J, Kershenobich D, Borras S, Tanno H, Prigositin N, D'Agostino D, Kalil J, Alvarez F, Satz ML. HLA and autoimmune hepatitis: 12th International Histocompatibility workshop study. Dans: Charron D (ed). HLA Genetic diversity of HLA function and medical implication. 1997; 418-423.

Hépatites autoimmunes - Alvarez F. Hépatites autoimmunes. Dans: Sokal E (ed). Progrès en hépato-gastroentérologie. 1996; 239-250.

Therapy of chronic viral hepatitis in children - Alvarez F. Therapy of chronic viral hepatitis in children. Clin Invest Med 1996; 19: 381-388.

Alagille's syndrome associated with cystic renal disease - Martin S, Garel L, Alvarez F. Alagille's syndrome associated with cystic renal disease. Arch Dis Child 1996; 74(3): 232-235.

Study of the B cell response to cytochrome P4502D6 in sera from chronic hepatitis C patients - Parez N, Herzog D, Jacqz-Aigrain E, Homberg J-C, Alvarez F. Study of the B cell response to cytochrome P4502D6 in sera from chronic hepatitis C patients. Clin Exp Immunol 1996; 106: 336-343.

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