Chercheur

    Nicole Lemieux , Ph.D.

    nicole.lemieux@umontreal.ca
    Nicole Lemieux
    Axe de recherche
    Cerveau et développement de l’enfant
    Adresse
    CHUSJ - Centre de Recherche

    Téléphone
    514 345-4931 #5354

    Fax
    514 345-4819

    Titres

    • Professeure agrégée, Département de pathologie et biologie cellulaire, Université de Montréal.
    • Directrice de recherche en cytogénétique et directrice, Laboratoire de diagnostic en cytogénétique postnatale, Département de pathologie, CHU Sainte-Justine.
    • Présidente, Association de cytogénétique du Québec.

    Intérêts de recherche

    • Cytogénétique moléculaire des anomalies chromosomiques retrouvées dans divers cancers dans le but d'étudier les mécanismes sous-jacents d'apparition et de propagation des cellules tumorales.
    • Caractérisation de nouvelles lignées de médulloblastomes par FISH et CGH.

    Recherches récentes

    • Cytogénétique moléculaire des anomalies chromosomiques dans les maladies génétiques : caractérisation des réarrangements complexes du chromosome Y chez l'homme.
    • Étude du maintien de l'intégrité des extrémités chromosomiques : rôle des télomères dans les anomalies chromosomiques de structure.
    • Évaluation chez l'humain des risques cytogénotoxiques de produits ou de métaux potentiellement cancérigènes et susceptibles d'être rencontrés en milieux occupationnels, cliniques et environnementaux : une analyse des bris simple-brin à l'ADN par marquage terminal in situ en microscopie électronique (EM-ISEL) dans la chromatine chromosomique et nucléaire.
    • Étude des niveaux supérieurs d'organisation ultrastructurale de la chromatine, normale et pathologique dans le chromosome métaphasique et dans le noyau interphasique par hybridation in situ en fluorescence et en microscopie électronique.

Publications

Identification of new susceptibility regions for X;Y translocations in patients with testicular disorder of sex development - Beaulieu Bergeron M, Lemyre E, Lemieux N. Identification of new susceptibility regions for X;Y translocations in patients with testicular disorder of sex development. Sex Dev 2011; 5(1): 1-6.

Undifferentiated gonadal tissue, Y chromosome instability and tumors in XY gonadal dysgenesis - Beaulieu Bergeron M, Lemieux N, Brochu P. Undifferentiated gonadal tissue, Y chromosome instability and tumors in XY gonadal dysgenesis. Pediatr Dev Pathol 2011; 14(6): 445-459.

Correlation of intercentromeric distance, mosaicism, and sexual phenotype: Molecular localization of breakpoints in isodicentric Y chromosomes - Beaulieu Bergeron M, Brochu P, Lemyre E, Lemieux N. Correlation of intercentromeric distance, mosaicism, and sexual phenotype: Molecular localization of breakpoints in isodicentric Y chromosomes. Am J Med Genet A 2011; 155(11): 2705-2712.

Optimizing urothelial cell preparation for the human urinary micronucleus assay - Fortin F, Anghel T, Brochu P, Lemieux N. Optimizing urothelial cell preparation for the human urinary micronucleus assay. Toxicol in Vitro 2010; 24(6): 1821-1827.

Co-existence of a choriocarcinoma and a gonadoblastoma in the gonad of a 46,XY female: A SNP array analysis - Beaulieu Bergeron M, Bouron-Dal Soglio D, Maietta A, Fournet JC, Blumenfeld M, Brochu DP, Lemieux N. Co-existence of a choriocarcinoma and a gonadoblastoma in the gonad of a 46,XY female: A SNP array analysis. Pediatr Dev Pathol 2010; 13(1): 66-71.

Handicaps et retard de développement: prévention et intervention précoce - L'Abbé Y, Lespinasse J, Labine R, Walther M, Lemieux N, Goyette C, Fortin F, Allard P, e. Handicaps et retard de développement: prévention et intervention précoce. Béliveau, 2010; 284 pages.

Diagnosis of true hermaphroditism in a fetus with acampomelic campomelic dysplasia - Beaulieu Bergeron M, Rypens FF, Scherer G, Lemyre E, Lemieux N, Fournet JC. Diagnosis of true hermaphroditism in a fetus with acampomelic campomelic dysplasia. Prenat Diagn 2009; 29(5): 528-530.

Frequency of chromosome healing and interstitial telomeres in 40 cases of constitutional abnormalities - Fortin F, Bergeron M, Fetni R, Lemieux N. Frequency of chromosome healing and interstitial telomeres in 40 cases of constitutional abnormalities. Cytogenet Genome Res 2009; 125(3): 176-185.

Specific language impairment as the prominent feature in a patient with a low-level trisomy 21 mosaicism - Paoloni-Giacobino A, Lemieux N, Lemyre E, Lespinasse J. Specific language impairment as the prominent feature in a patient with a low-level trisomy 21 mosaicism. J Intell Disabil Res 2007; 51(Pt 5): 401-405.

Role of oxidative stress and intracellular calcium in nickel carbonate hydroxide-induced sister-chromatid exchange, and alterations in replication index and mitotic index in cultured human peripheral blood lymphocytes - M'Bemba-Meka P, Lemieux N, Charkrabarti S. Role of oxidative stress and intracellular calcium in nickel carbonate hydroxide-induced sister-chromatid exchange, and alterations in replication index and mitotic index in cultured human peripheral blood lymphocytes. Arch Toxicol 2007; 81(2): 89-99.

Chromosomal abnormalities - Gilbert-Barness E, Oligny LL, Fetni R, Lemieux N. Chromosomal abnormalities. Dans: Gilbert-Barness E, Kapur R, Oligny LL, Siebert J (eds). Potter's Pathology of the Fetus, Infant and Child, 2nd edition. Mosby-Elsevier, 2007; 205-267.

Familial deletion 18p syndrome: Case report - Maranda B, Lemieux N, Lemyre E. Familial deletion 18p syndrome: Case report. BMC Med Genet 2006; 7(1): 60 .

Role of oxidative stress, mitochondrial membrane potential, and calcium homeostasis in nickel subsulfide-induced human lymphocyte death in vitro - M'Bemba-Meka P, Lemieux N, Chakrabarti S. Role of oxidative stress, mitochondrial membrane potential, and calcium homeostasis in nickel subsulfide-induced human lymphocyte death in vitro. Sci Total Environ 2006; 369(1-3): 21-34.

Role of oxidative stress, mitochondrial membrane potential, and calcium homeostasis in human lymphocyte death induced by nickel carbonate hydroxide in vitro - M'Bemba-Meka P, Lemieux N, Chakrabarti S. Role of oxidative stress, mitochondrial membrane potential, and calcium homeostasis in human lymphocyte death induced by nickel carbonate hydroxide in vitro. Arch Toxicol 2006; 80(7): 405-420.

Genotoxic effects of chromium(VI) and cadmium(II) in human blood lymphocytes using the electron microscopy in situ end-labeling (EM-ISEL) assay - Depault F, Cojocaru M, Fortin F, Charkrabarti S, Lemieux N. Genotoxic effects of chromium(VI) and cadmium(II) in human blood lymphocytes using the electron microscopy in situ end-labeling (EM-ISEL) assay. Toxicol in Vitro 2006; 20(4): 513-518.

Dynamic increase of a 45,X cell line in a patient with multicentric ring Y chromosomes - Desgroseillers M, Fortin F, Lafrenière AM, Brochu P, Lemyre E, Lemieux N. Dynamic increase of a 45,X cell line in a patient with multicentric ring Y chromosomes. Cytogenet Genome Res 2006; 115(1): 90-93.

Complex mosaicism in sex reversed SRY+ male twins - Desgroseillers M, Fortin F, Lemyre E, Lemieux N. Complex mosaicism in sex reversed SRY+ male twins. Cytogenet Genome Res 2006; 112(1-2): 176-179.

Male pseudohermaphroditism and gonadal mosaicism in a 47,XY,+22 fetus - Beaulieu Bergeron M, Tran-Thanh D, Fournet JC, Lemyre E, Lemieux N, Bouron-Dal Soglio D. Male pseudohermaphroditism and gonadal mosaicism in a 47,XY,+22 fetus. Am J Med Genet A 2006; 140(16): 1768-1772.

Phenotypic variability in isodicentric Y patients: study of nine cases - Desgroseillers M, Beaulieu Bergeron M, Brochu P, Lemyre E, Lemieux N. Phenotypic variability in isodicentric Y patients: study of nine cases. Clin Genet 2006; 70(2): 145-150.

Nickel compound-induced DNA single-strand breaks in chromosomal and nuclear chromatin in human blood lymphocytes in vitro: Role of oxidative stress and intracellular calcium - M'Bemba-Meka P, Lemieux N, Chakrabarti S. Nickel compound-induced DNA single-strand breaks in chromosomal and nuclear chromatin in human blood lymphocytes in vitro: Role of oxidative stress and intracellular calcium. Mutat Res 2005; 586(2): 124-137.

Role of oxidative stress, mitochondrial membrane potential, and calcium homeostasis in nickel sulfate-induced human lymphocyte death in vitro - M'Bemba-Meka P, Lemieux N, Chakrabarti S. Role of oxidative stress, mitochondrial membrane potential, and calcium homeostasis in nickel sulfate-induced human lymphocyte death in vitro. Chem Biol Interact 2005; 156(1): 69-80.

Complex chromosome rearrangement and recombinant balanced translocation in a mother and a daughter with the same phenotypic abnormalities - Tihy F, Lemieux N, Lemyre E. Complex chromosome rearrangement and recombinant balanced translocation in a mother and a daughter with the same phenotypic abnormalities. Am J Med Genet A 2005; 135(3): 317-319.

Prévention du retard mental: Enjeux cliniques, éthiques et sociaux. Volume 2 - L'Abbé Y, Labine R, Lemieux N, Lespinasse J, e. Prévention du retard mental: Enjeux cliniques, éthiques et sociaux. Volume 2. Éditions Sciences et Culture Inc., 2005; 363 pages.

Prévention du retard mental: Causes et conduites préventives à adopter. Volume 1 - L'Abbé Y, Labine R, Lemieux N, Lespinasse J, e. Prévention du retard mental: Causes et conduites préventives à adopter. Volume 1. Éditions Sciences et Culture Inc., 2004; 168 pages.

Les chromosomes sexuels: de l'origine à la réversion sexuelle - Desgroseillers M, Lemieux N. Les chromosomes sexuels: de l'origine à la réversion sexuelle. Dire 2003; 13: 44-46.

Rearrangement of the MLL gene and a region proximal to the RARa gene in a case of acute myelocytic leukemia M5 with a t(11;17)(q23;q21) - Dubé S, Fetni R, Hazourli S, Champagne M, Lemieux N. Rearrangement of the MLL gene and a region proximal to the RARa gene in a case of acute myelocytic leukemia M5 with a t(11;17)(q23;q21). Cancer Genet Cytogenet 2003; 145: 54-59.

Tetrasomy Y by structural rearrangement: Clinical report - Desgroseillers M, Lemyre E, Dallaire L, Lemieux N. Tetrasomy Y by structural rearrangement: Clinical report. Am J Med Genet 2002; 111(4): 1-4.

Molecular cloning, tissue distribution and chromosomal localization of MMEL2, a gene coding for a novel human member of the neutral endopeptidase.11 family - Bonvouloir N, Lemieux N, Crine P, Boileau G, Desgroseillers L. Molecular cloning, tissue distribution and chromosomal localization of MMEL2, a gene coding for a novel human member of the neutral endopeptidase.11 family. DNA Cell Biol 2001; 20(8): 493-498.

High-resolution and replication banding (850-1250) bands - Fetni R, Drouin R, Richer C, Lemieux N. High-resolution and replication banding (850-1250) bands. Dans: Miller OJ, Therman E (eds). Human Chromosomes, 4e édition. New York. Springler-Verlag, 2001; 79-94.

Quand le sexe devient ambigu: des filles XXX, des gars XXY - Élie MP, Desgroseillers M, Lemieux N. Quand le sexe devient ambigu: des filles XXX, des gars XXY. Québec Science 2001; 12-16.

A supernumery chromosome inherited from a maternal balanced translocation leading to pure trisomy 9p - Tihy F, Lemyre E, Dallaire L, Lemieux N. A supernumery chromosome inherited from a maternal balanced translocation leading to pure trisomy 9p. Am J Med Genet 2000; 91: 383-386.

In vitro biocompatibility testing of nickel-titanium: comparison with pure nickel, pure titanium, and 316-L stainless steel - Assad M, Lemieux N, Rivard C-H, Yahia LH. In vitro biocompatibility testing of nickel-titanium: comparison with pure nickel, pure titanium, and 316-L stainless steel. Orthopae Trans 1999; 22(3): 892-893.

Comparative in vitro biocompatibility of nichel-titanium, pure titanium and stainless steel: genotoxicity and atomic absorption evaluation - Assad M, Lemieux N, Yahia LH, Rivard C-H. Comparative in vitro biocompatibility of nichel-titanium, pure titanium and stainless steel: genotoxicity and atomic absorption evaluation. J Biomed Mater Res A 1999; 9: 1-12.

A new case of a de novo dup(X)(q22.1q25) in a girl with an abnormal phenotype - Tihy F, Lemyre E, Lemieux N, Dallaire L. A new case of a de novo dup(X)(q22.1q25) in a girl with an abnormal phenotype. Am J Med Genet 1999; 87: 302-305.

Persistent hyperplaxtic primary vitreous with retinal tumor in tuberous sclerosis: Report of a case including tumoral immunohistochemistry and cytogenetic analyses - Milot J, Michaud J, Lemieux N, Allaire GS, Gagnon MM. Persistent hyperplaxtic primary vitreous with retinal tumor in tuberous sclerosis: Report of a case including tumoral immunohistochemistry and cytogenetic analyses. Ophthalmology 1999; 106(3): 630-634.

Increased resolution of in situ hybridization signal detection by electron microscopy: A comparison with fluorescence microscopy - Fetni R, Scott P, Tihy F, Richer C, Lemieux N. Increased resolution of in situ hybridization signal detection by electron microscopy: A comparison with fluorescence microscopy. Genome 1999; 42: 1001-1007.

The human TDE gene homologue: Localization to 20q13.1-13.3 and variable expression in human tumor cell lines and tissue - Bossolasco M, Lebel MH, Lemieux N, Mes-Masson AM. The human TDE gene homologue: Localization to 20q13.1-13.3 and variable expression in human tumor cell lines and tissue. Mol Carcinog 1999; 26: 189-200.

Del(14)(q22.1q23.2) in a patient with anophthalmia and pituitary hypoplasia - Lemyre E, Lemieux N, Décarie JC, Lambert MA. Del(14)(q22.1q23.2) in a patient with anophthalmia and pituitary hypoplasia. Am J Med Genet 1998; 77: 162-165.

Cytogenetic analysis of a parachordoma - Tihy F, Scott P, Russo P, Champagne M, Tabet JC, Lemieux N. Cytogenetic analysis of a parachordoma. Cancer Genet Cytogenet 1998; 105: 14-19.

In vitro biocompatibility assessment of a nickel-titanium alloy using electron microscopy in situ end-labeling (EM-ISEL) - Assad M, Yahia LH, Rivard C-H, Lemieux N. In vitro biocompatibility assessment of a nickel-titanium alloy using electron microscopy in situ end-labeling (EM-ISEL). J Biomed Mater Res A 1998; 41: 154-161.

Interstitial telomeric sequences and fragile sites: a dilemma - Lemieux N, Boutouil M, Fetni R, Qu J, Dallaire L, Richer C. Interstitial telomeric sequences and fragile sites: a dilemma. Hum Genet 1997; 101: 252-253.

Etopic gene targeting exibits a bimodal distribution of integration in murine cells, indicating both intra and interchromosomal sites are accessible to the targeting vector - Dellaire G, Lemieux N, Belmaaza A, Chartand P. Etopic gene targeting exibits a bimodal distribution of integration in murine cells, indicating both intra and interchromosomal sites are accessible to the targeting vector. Mol Cell Biol 1997; 17: 5571-5580.

Immunogoid electron microscopy in situ end-labeling (EM-ISEL): assay for biomaterial DNA damage detection - Assad M, Lemieux N, Rivard C-H. Immunogoid electron microscopy in situ end-labeling (EM-ISEL): assay for biomaterial DNA damage detection. Biomed Mater Eng 1997; 7: 391-400.

DNA replication asynchrony between the paternal and maternal alleles of imprinted genes does not straddle the R/G transition - Drouin R, Boutouil M, Fetni R, Holmquist GP, Scott P, Richer C, Lemieux N. DNA replication asynchrony between the paternal and maternal alleles of imprinted genes does not straddle the R/G transition. Chromosoma 1997; 106: 405-411.

Effects of basic fibroblast growth factor on the differentiation, growth, and viability of a new human medulloblastoma cell line (UM-MB1) - Kenigsberg RL, Hong Y, Yao H, Lemieux N, Michaud J, Tautu C, Théorêt Y. Effects of basic fibroblast growth factor on the differentiation, growth, and viability of a new human medulloblastoma cell line (UM-MB1). Am J Pathol 1997; 151: 867-881.

Cytological characterization of two distinct alpha satellite DNA domains on humains on human chromosome 7, using double-labelling hybridizations in fluorescence and electron microscopy on an melanoma cell line - Fetni R, Richer C, Malfoy B, Dutrillaux B, Lemieux N. Cytological characterization of two distinct alpha satellite DNA domains on humains on human chromosome 7, using double-labelling hybridizations in fluorescence and electron microscopy on an melanoma cell line. Cancer Genet Cytogenet 1997; 96: 17-22.

Structural heterogeneity of HSR (11) in the MDA-MB-134 mammary carcinome cell line - Lemieux N, Apiou F, Tihy F, Vogt N, Malfoy B, Dutrillaux B. Structural heterogeneity of HSR (11) in the MDA-MB-134 mammary carcinome cell line. Cancer Genet Cytogenet 1996; 90: 75-79.

Localization of a human double-stranded RNA-binding protein gene to band 20q13.13 by fluorescence in situ hybridization - Desgroseillers L, Lemieux N. Localization of a human double-stranded RNA-binding protein gene to band 20q13.13 by fluorescence in situ hybridization. Genomics 1996; 36: 527-529.

Comparative RB1 gene mapping in Homo sapiens, Pithecia pithecia, Macaca sylvana and Cercopithecus asthiops tantalus: evidence for centromeric shift in Cercopithecidae - Tihy F, Lemieux N, Lombard M, Dutrillaux B. Comparative RB1 gene mapping in Homo sapiens, Pithecia pithecia, Macaca sylvana and Cercopithecus asthiops tantalus: evidence for centromeric shift in Cercopithecidae. Cytogenet Cell Genet 1996; 72: 9-11.

Structure of the gene coding for the TRiC-P5 subunit of the cytosolic chaperonin TRiC - Sévigny G, Lemieux N, Steyaert A, Bibord-Hardy V. Structure of the gene coding for the TRiC-P5 subunit of the cytosolic chaperonin TRiC. Genomics 1996; 31: 107-110.

Characterization by fluorescence and electron microscopy in situ hybridization of a double Y isochromosome - Fetni R, Krabchi K, Messier PE, Richer C, Lemieux N. Characterization by fluorescence and electron microscopy in situ hybridization of a double Y isochromosome. Am J Med Genet 1996; 63: 454-457.

Fragile site and interstitial telomere repeat sequences at the fusion point of a de novo Y:13 translocation - Boutouil M, Fetni R, Qu J, Dallaire L, Richer C, Lemieux N. Fragile site and interstitial telomere repeat sequences at the fusion point of a de novo Y:13 translocation. Hum Genet 1996; 98: 323-327.

Complementary replication R- and G-band induced by cell blocking at the R-band/G-band transition: a possible regulary checkpoint within the S phase of the cell cycle - Fetni R, Drouin R, Richer C, Lemieux N. Complementary replication R- and G-band induced by cell blocking at the R-band/G-band transition: a possible regulary checkpoint within the S phase of the cell cycle. Cytogenet Cell Genet 1996; 75: 172-179.

Comparative mapping of Na+-Phosphate cotransporter genes, NPT1 and NPT2, in human and rabbit - Kos CH, Tihy F, Murer H, Lemieux N, Tenenhouse HS. Comparative mapping of Na+-Phosphate cotransporter genes, NPT1 and NPT2, in human and rabbit. Cytogenet Cell Genet 1996; 75: 22-24.

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