Chercheur

    Christian Beauséjour , Ph.D.

    c.beausejour@umontreal.ca
    Christian Beauséjour
    Axe de recherche
    Maladies virales, immunitaires et cancers
    Thème de recherche
    Transplantation de cellules souches hématopoïétiques et immunothérapies
    Adresse
    CHUSJ - Centre de Recherche

    Téléphone
    514 345-4931 #4385

    Fax
    514-345-4931

    Titres

    • Professeur agrégé, Département de pharmacologie et physiologie, Université de Montréal
    • Chercheur, Centre de recherche du CHU Sainte-Justine

    Formation

    • Chercheur, Sangamo Biosciences, Californie, USA (2004-2005)
    • Post-doctorat, Berlex Biosciences, Californie, USA (2003-2004)
    • Post-doctorat, Berkeley National Laboratory, Californie, USA (2001-2003)
    • Doctorat, Pharmacologie, Université de Montréal (1996-2001)

    Intérêts de recherche

    • Le rôle de la sénescence cellulaire dans le renouvellement tissulaire et le cancer
    • Thérapie cellulaire utilisant les cellules souches pluripotentes induites (iPSC)

    Expertises de recherche

    • Mécanismes de sénescence cellulaire
    • Transfert et correction génique
    • Reprogrammation cellulaire
    • Modèle murin
    • Cellules souches et progénitrices

    Publications significatives

    1. Palacio L, Le O, Krishna V, Sharpless NE and Beauséjour CM. Sustained p16INK4a expression is required to prevent IR-induced tumorigenesis in mice. Oncogene 2016.
    2. Despars G, Carbonneau C, Bardeau P, Coutu D and Beausejour CM. Loss of the osteogenic differentiation potential during senescence is limited to bone progenitor cells and is dependent on p53. PLoS ONE  2013.
    3. Fortin A, Benabdallah B, Palacio L, Carbonneau C, Le O, Haddad E and Beausejour CM.  A soluble G-CSF decoy receptor as an alternative tool to alter hematopoietic cells homing and reconstitution. Stem Cell and Development. 2013.
    4. Benabdallah BF, Duval A, Rousseau J, Chapdelaine P, Holmes MC, Haddad E,  Tremblay JP and Beauséjour CM.  Targeted gene addition of microdystrophin in mice skeletal muscle via human myoblast transplantation. Molecular Therapy Nucleic Acids. 2013.
    5. Carbonneau C, Despars G, Shanti Rojas-Sutterlin, Fortin A, Le O, Hoang T and Beausejour CM.  Ionizing radiation-induced expression of INK4a/ARF in murine bone marrow-derived stromal cell populations interferes with bone marrow homeostasis. Blood. 2012.

Publications

A soluble granulocyte colony stimulating factor decoy receptor as a novel tool to increase hematopoietic cell homing and reconstitution in mice - Fortin A, Benabdallah BF, Palacio L, Carbonneau C, Lê O, Haddad E, Beauséjour C. A soluble granulocyte colony stimulating factor decoy receptor as a novel tool to increase hematopoietic cell homing and reconstitution in mice. Stem Cells Dev 2013; 22(6): 975-984.

Expression of the senescence marker p16INK4a in skin biopsies of acute lymphoblastic leukemia survivors: a pilot study - Marcoux S, Le ON, Langlois-Pelletier C, Laverdière C, Hatami A, Robaey P, Beauséjour C. Expression of the senescence marker p16INK4a in skin biopsies of acute lymphoblastic leukemia survivors: a pilot study. Radiat Oncol 2013; 8(1): 252.

Loss of the osteogenic differentiation potential during senescence is limited to bone progenitor cells and is dependent on p53 - Despars G, Carbonneau CL, Bardeau P, Coutu DL, Beauséjour C. Loss of the osteogenic differentiation potential during senescence is limited to bone progenitor cells and is dependent on p53. PLoS ONE 2013; 8(8): e73206.

Targeted gene addition of microdystrophin in mice skeletal muscle via human myoblast transplantation - Benabdallah BF, Duval A, Rousseau J, Chapdelaine P, Holmes M, Haddad E, Tremblay JP, Beauséjour C. Targeted gene addition of microdystrophin in mice skeletal muscle via human myoblast transplantation. Mol Ther Nucleic Acids 2013; 2: e68.

Cord blood-derived mesenchymal stromal cells down-modulate CD4+ T-cell activation by inducing IL-10 producing Th1 cells - Selleri S, Dieng Mame M, Nicoletti S, Louis I, Beauséjour C, Le Deist F, Haddad E. Cord blood-derived mesenchymal stromal cells down-modulate CD4+ T-cell activation by inducing IL-10 producing Th1 cells. Stem Cells Dev 2013; 22(7): 1063-1075.

p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes - Davalos AR, Kawahara M, Malhotra GK, Schaum N, Huang J, Ved U, Beauséjour C, Coppe JP, Rodier F, Campisi J. p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes. J Cell Biol 2013; 201(4): 613-629.

Ionizing radiation-induced expression of INK4a/ARF in murine bone marrow-derived stromal cell populations interferes with bone marrow homeostasis - Carbonneau C, Despars G, Rojas-Sutterlin S, Fortin A, Lê O, Hoang T, Beauséjour C. Ionizing radiation-induced expression of INK4a/ARF in murine bone marrow-derived stromal cell populations interferes with bone marrow homeostasis. Blood 2012; 119(3): 717-726.

Therapeutic efficacy of cord blood-derived mesenchymal stromal cells for the prevention of acute GVHD in a xenogenic mouse model - Grégoire-Gauthier J, Selleri S, Fontaine F, Dieng Mame M, Patey N, Despars G, Beauséjour C, Haddad E. Therapeutic efficacy of cord blood-derived mesenchymal stromal cells for the prevention of acute GVHD in a xenogenic mouse model. Stem Cells Dev 2012; 21(10): 1616-1626.

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation - Fumagalli M, Rossiello F, Clerici M, Barozzi S, Cittaro D, Kaplunov JM, Bucci G, Dobreva M, Matti V, Beauséjour C, Herbig U, Longhese MP, d'Adda di Fagagna F. Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation. Nature Cell BIol 2012; 14(4): 355-365.

Ischemic neurons prevent vascular regeneration of neural tissue by secreting semaphorin 3A - Joyal JS, Sitaras N, Binet F, Rivera JC, Stahl A, Zaniolo K, Shao Z, Polosa A, Zhu T, Hamel D, Djavari M, Kunik D, Honoré JC, Picard E, Zabeida A, Varma D, Hickson GR, Mancini J, Klagsbrun M, Costantino S, Beauséjour C, Lachapelle P, Smith LE, Chemtob S, Sapieha P. Ischemic neurons prevent vascular regeneration of neural tissue by secreting semaphorin 3A. Blood 2011; 117(22): 6024-6035 (Article de page couverture et éditorial).

DNA-SCARS: distinct nuclear structure that sustain damage-induced senescence growth arrest and inflammatory secretion - Rodier F, Munoz D, Teachenor R, Chu V, Lê O, Bhaumik D, Coppe JP, Beauséjour C, Kim SH, Davalos AR, Campisi J. DNA-SCARS: distinct nuclear structure that sustain damage-induced senescence growth arrest and inflammatory secretion. J Cell Sci 2011; 124(Pt 1): 68-81.

Ischemic neurons prevent vascular regeneration of neural tissue by secreting semaphorin 3A - Joyal JS, Sitaras N, Binet F, Rivera JC, Stahl A, Zaniolo K, Shao Z, Polosa A, Zhu T, Hamel D, Djavari M, Kunik D, Honoré JC, Picard E, Zabeida A, Varma D, Hickson GR, Mancini J, Klagsbrun M, Costantino S, Beauséjour C, Lachapelle P, Smith LE, Chemtob S, Sapieha P. Ischemic neurons prevent vascular regeneration of neural tissue by secreting semaphorin 3A. Blood 2011; 117(22): 6024-6035.

Targeted gene addition to human mesenchymal stromal cells as a cell-based plasma-soluble protein delivery platform - Benabdallah BF, Allard E, Yao S, Friedman G, Gregory P, Eliopoulos N, Fradette J, Spees JL, Haddad E, Holmes M, Beauséjour C. Targeted gene addition to human mesenchymal stromal cells as a cell-based plasma-soluble protein delivery platform. Cytotherapy 2010; 12(3): 394-399.

A human-like senescence-associated secretory phenotype is conserved in mouse cells dependent on physiological oxygen - Coppe JP, Patil CK, Rodier F, Krtolica A, Beauséjour C, Parrinello S, Hodgson JG, Chin K, Desprez PY, Campisi J. A human-like senescence-associated secretory phenotype is conserved in mouse cells dependent on physiological oxygen. PLoS ONE 2010; 5(2): e9188.

Secretion of SDF-1alpha by bone marrow-derived stromal cells enhances skin wound healing of C57BL/6 mice exposed to ionizing radiation - Landry Y, Lê O, Mace KA, Restivo TE, Beauséjour C. Secretion of SDF-1alpha by bone marrow-derived stromal cells enhances skin wound healing of C57BL/6 mice exposed to ionizing radiation. J Cell Mol Med 2010; 14(6B): 1594-1604.

Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status - Lê O, Rodier F, Fontaine F, Coppe JP, Campisi J, Degregori J, Laverdière C, Kokta V, Haddad E, Beauséjour C. Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status. Aging Cell 2010; 9(3): 398-409.

The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis - Sapieha P, Sirinyan M, Hamel D, Zaniolo K, Cho JH, Joyal JS, Honoré JC, Kermorvant-Duchemin E, Varma D, Tremblay S, Leduc M, Rihakova L, Hardy P, Klein WH, Mu X, Mamer O, Di Polo A, Beauséjour C, Mitchell GA, Andelfinger G, Sennlaub F, Chemtob S. The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis. Nat Med 2008; 14(10) : 1067-1076.

The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis - Sapieha P, Sirinyan M, Hamel D, Zaniolo K, Cho JH, Joyal JS, Honoré JC, Kermorvant-Duchemin E, Varma D, Tremblay S, Leduc M, Rihakova L, Hardy P, Klein WH, Mu X, Mamer O, Di Polo A, Beauséjour C, Mitchell GA, Andelfinger G, Sennlaub F, Chemtob S. The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis. Nat Med 2008; 14(10) : 1067-1076.

Blockade of sensory abnormalities and kinin B(1) receptor expression by N-Acetyl-l-Cysteine and ramipril in a rat model of insulin resistance - Ismael MA, Talbot S, Carbonneau CL, Beauséjour C, Couture R. Blockade of sensory abnormalities and kinin B(1) receptor expression by N-Acetyl-l-Cysteine and ramipril in a rat model of insulin resistance. Eur J Pharmacol 2008; 589(1-3): 66-72.

Telomere dysfunction and cell survival: roles for distinct TIN2-containing complexes - Kim SH, Davalos AR, Heo SJ, Rodier F, Zou Y, Beauséjour C, Kaminker P, Yannone SM, Campisi J. Telomere dysfunction and cell survival: roles for distinct TIN2-containing complexes. J Biol Chem 2008; 181(3): 447-460.

Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery - Lombardo A, Genovese P, Beauséjour C, Colleoni S, Lee YL, Kim K, Ando A, Urnov F, Galli C, Gregory P, Holmes M, Naldini L. Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery. Nature Biotechnol 2007; 25(11): 1298-1306.

Bone marrow-derived cells: the influence of aging and cellular senescence. Review - Beauséjour C. Bone marrow-derived cells: the influence of aging and cellular senescence. Review. Handb Exp Pharmacol 2007; (180): 67-88.

An improved zinc-finger nuclease architecture for highly specific genome editing - Miller JC, Holmes M, Wang J, Guschin D, Lee YL, Rupniewski I, Beauséjour C, Waite A, Wang N, Kim K, Gregory P, Pabo CO, Rebar EJ. An improved zinc-finger nuclease architecture for highly specific genome editing. Nature Biotechnol 2007; 25(7): 778-785.

Ageing: Balancing regeneration and cancer - Beauséjour C, Campisi J. Ageing: Balancing regeneration and cancer. Nature 2006; 443(7110): 404-405.

Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence - Coppe JP, Kauser K, Campisi J, Beauséjour C. Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence. J Biol Chem 2006; 281(40): 29568-29574.

Age-dependent acceleration of ischemic injury in endothelial nitric oxide synthase-deficient mice: potential role of impaired VEGF receptor 2 expression - Qian HS, de Resende MM, Beauséjour C, Huw LY, Liu P, Rubanyi GM, Kauser K. Age-dependent acceleration of ischemic injury in endothelial nitric oxide synthase-deficient mice: potential role of impaired VEGF receptor 2 expression. J Cardiovasc Pharmacol 2006; 47(4): 587-593.

Highly efficient endogenous human gene correction using designed zinc-finger nucleases - Urnov F, Miller J, Lee Y, Beauséjour C, Rock J, Augustus S, Jamieson A, Porteus M, Gregory P, Holmes M. Highly efficient endogenous human gene correction using designed zinc-finger nucleases. Nature 2005; 435(7042): 646-651.

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