Chercheur

    François Proulx , M.D.

    francois.proulx.3@umontreal.ca
    François Proulx
    Adresse
    CHUSJ - Centre de Recherche

    Téléphone
    514 345-4931 #5562

    Fax
    514 345-4822

    Titres

    • Professeur agrégé de clinique, Département de pédiatrie, Université de Montréal.

    Intérêts de recherche

    • Développement d'un modèle animal de syndrome hémolytique urémique causé par la shigatoxine;
    • Caractérisation de la réponse inflammatoire (neutrophiles circulants) dans le syndrome hémolytique urémique chez l'enfant;
    • Étude d'un polymorphisme du TNF dans le syndrome hémolytique urémique.

Publications

Hemodynamic monitoring by transpulmonary thermodilution and pulse contour analysis in critically ill children - Proulx F, Lemson J, Choker G, Tibby SM. Hemodynamic monitoring by transpulmonary thermodilution and pulse contour analysis in critically ill children. Pediatr Crit Care Med 2011; 12(4): 459-466.

Hemodynamic monitoring by pulse contour analysis in critically ill children with congenital heart disease - Proulx F, Lemson J, Choker G, Tibby SM. Hemodynamic monitoring by pulse contour analysis in critically ill children with congenital heart disease . Pediatr Crit Care Med 2011; 12(5): 609-610.

Eculizumab in severe Shiga-toxin-associated HUS - Lapeyraque AL, Malina M, Frémeaux-Bacchi V, Boppel T, Kirschfink M, Oualha M, Proulx F, Clermont MJ, Le Deist F, Niaudet P, Schaefer F. Eculizumab in severe Shiga-toxin-associated HUS. N Engl J Med 2011; 364(26): 2561-2563.

Daily estimation of the severity of multiple organ dysfunction syndrome in critically ill children - Leteurtre S, Duhamel A, Grandbastien B, Proulx F, Cotting J, Gottesman R, Joffe A, Wagner B, Hubert P, Martinot A, Lacroix J, Leclerc F. Daily estimation of the severity of multiple organ dysfunction syndrome in critically ill children. CMAJ 2010; 182(11): 1181-1187.

Differences in organ dysfunctions between neonates and older children: a prospective, observational, multicenter study - Bestati N, Leteurtre S, Duhamel A, Proulx F, Grandbastien B, Lacroix J, Leclerc F. Differences in organ dysfunctions between neonates and older children: a prospective, observational, multicenter study. Crit Care 2010; 14(6): R202 doi: 10.1186/cc9323.

The pediatric multiple organ dysfunction syndrome - Proulx F, Joyal JS, Maricelsco MM, Leteurtre S, Leclerc F, Lacroix J. The pediatric multiple organ dysfunction syndrome. Pediatr Crit Care Med 2009; 10(1): 12-22.

Detergent-resistant globotriaosyl ceramide may define verotoxin/glomeruli-restricted hemolytic uremic syndrome pathology - Khan F, Proulx F, Lingwood C. Detergent-resistant globotriaosyl ceramide may define verotoxin/glomeruli-restricted hemolytic uremic syndrome pathology. Kidney Int 2009; 75(11): 1209-1216.

Feasibility and reliability of Doppler flow recordings in the fetal aortic isthmus: a multicenter evaluation - Fouron J-C, Siles A, Montanari L, Morin L, Ville Y, Mivelaz Y, Proulx F, Bureau N, Bigras JL, Brassard M. Feasibility and reliability of Doppler flow recordings in the fetal aortic isthmus: a multicenter evaluation. Ultrasound Obstet Gynecol 2009; 33(6): 690-693.

Involvement of the fractalkine pathway in the pathogenesis of childhood hemolytic uremic syndrome - Ramos MV, Fernandez GC, Patey N, Schierloh P, Exeni R, Grimoldi I, Vallejo G, Elias-Costa C, Del Carmen Sasiain M, Trachtman H, Combadière C, Proulx F, Palermo M. Involvement of the fractalkine pathway in the pathogenesis of childhood hemolytic uremic syndrome. Blood 2007; 109(6): 2438-2445.

Thrombotic microangiopathy, hemolytic uremic syndrome, and thromobtic thrombocytopenic purpura - Proulx F, Tesh VL. Thrombotic microangiopathy, hemolytic uremic syndrome, and thromobtic thrombocytopenic purpura. Dans: Wheeler DS, Wong HR, Shaley TP(eds). Pediatric Critical Care Medicine: Basic science and clinical evidence. London. Springer-Verlag, 2007; 1189-1203.

Syndrome hémolytique et urémique et purpura thrombotique thrombocytopénique - Proulx F, Loirat C, Ramet J, Hébert MJ. Syndrome hémolytique et urémique et purpura thrombotique thrombocytopénique. Dans: Lacroix J, Gauthier M, Hubert P, Leclerc F, Gaudreault P (eds). Urgences et soins intensifs pédiatriques. Montréal et Paris. Éditions du CHU Sainte-Justine et Elsevier Masson, 2007; 745-759.

Obstruction des voies respiratoires supérieures d'origine infectieuse - Proulx F, Turgeon J, Girodias JB. Obstruction des voies respiratoires supérieures d'origine infectieuse. Dans: Turgeon J, Bernard-Bonnin AC, Gervais P, Ovetchkine P, Gauthier M (eds). Dictionnaire de thérapeutique pédiatrique Weber, 2e édition. Boucherville. Gaëtan Morin, 2007; 934-938.

Syndrome de défaillance multiviscérale - Proulx F, Leteurtre S, Leclerc S, Lacroix J, Van den Berghe G, Vanasse M. Syndrome de défaillance multiviscérale. Dans: Lacroix J, Gauthier M, Hubert P, Leclerc F, Gaudreault P (eds). Urgences et soins intensifs pédiatriques. Montréal et Paris. Éditions du CHU Sainte-Justine et Elsevier Masson, 2007; 143-165.

Le syndrome de défaillance multiviscérale chez l'enfant: étiopathogénie (Pediatric multiple organ dysfunction syndrome: physiopathology) - Lacroix J, Proulx F. Le syndrome de défaillance multiviscérale chez l'enfant: étiopathogénie (Pediatric multiple organ dysfunction syndrome: physiopathology). Dans: Brissaud O (ed). Actualités en Réanimation et Urgences. Paris. Elsevier, 2007; 580-591.

Hypertension artérielle - Mérouani A, Proulx F, Bernard-Bonnin A-C. Hypertension artérielle. Dans: Turgeon J, Bernard-Bonnin AC, Gervais P, Ovetchkine P, Gauthier M (eds). Dictionnaire de thérapeutique pédiatrique Weber, 2e édition. Boucherville. Gaëtan Morin, 2007; 621-628.

Sepsis et choc septique - Leclerc F, Lacroix J, Proulx F, Tapiero B, Hazelzet J. Sepsis et choc septique. Dans: Lacroix J, Gauthier M, Hubert P, Leclerc F, Gaudreault P (eds). Urgences et soins intensifs pédiatriques. Montréal et Paris. Éditions du CHU Sainte-Justine et Elsevier Masson, 2007; 211-240.

Hypertension pulmonaire - Clément de Cléty S, Gordon JB, Proulx F, Begheti M. Hypertension pulmonaire. Dans: Lacroix J, Gauthier M, Hubert P, Leclerc F, Gaudreault P (eds). Urgences et soins intensifs pédiatriques. Montréal et Paris. Éditions du CHU Sainte-Justine et Elsevier Masson, 2007; 467-481.

Induction of apoptosis by herpes simplex virus in neonatal but not adult neutrophils - Ennaciri J, Menezes J, Proulx F, Toledano B. Induction of apoptosis by herpes simplex virus in neonatal but not adult neutrophils. Pediatr Res 2006; 59(1): 7-12.

Prospective surveillance of Canadian children with the haemolytic uraemic syndrome - Proulx F, Sockett P. Prospective surveillance of Canadian children with the haemolytic uraemic syndrome. Pediatr Nephrol 2005; 20(6): 786-90.

Procalcitonin in children with Escherichia coli O157:H7 associated hemolytic uremic syndrome - Decaluwé H, Harrison L, Mariscalco MM, Gendrel D, Bohuon C, Tesh VL, Proulx F. Procalcitonin in children with Escherichia coli O157:H7 associated hemolytic uremic syndrome. Pediatr Res 2005; 59(4 Pt 1): 579-583.

Cumulative influence of organ dysfunctions and septic state on mortality of critically ill children - Leclerc F, Leteurtre S, Duhamel A, Grandbastien B, Proulx F, Martinot A, Gauvin F, Hubert P, Lacroix J. Cumulative influence of organ dysfunctions and septic state on mortality of critically ill children. Am J Respir Crit Care Med 2005; 171(4): 348-353.

Active recombinant factor VII for refractory bleeding during extracorporeal membrane oxygenation - Verrijckt A, Proulx F, Morneau S, Vobecky S. Active recombinant factor VII for refractory bleeding during extracorporeal membrane oxygenation. J Thorac Cardiovasc Surg 2004; 127(6): 1812-1813.

Sepse/Sindrome da resposta inflamatoria systêmica (SRIS) (Sepsis and systemic inflammatory syndrome (SIRS)) - Simon L, Farrell CA, Lacroix J, Proulx F, Toledano B, Piva JP, Garcia PCR. Sepse/Sindrome da resposta inflamatoria systêmica (SRIS) (Sepsis and systemic inflammatory syndrome (SIRS)). Dans: Piva JP, Garcia PCR (eds). Medicina intensiva em Pediatra, 5e édition. Rio de Janiero. Editora Medsi, 2004; 103-134.

Validation of the paediatric logistic organ dysfunction (PELOD) score: prospective, observational, multicentre study - Leteurtre S, Martinot A, Duhamel A, Proulx F, Grandbastien B, Cotting J, Gottesman R, Joffe A, Pfenninger J, Hubert P, Lacroix J, Leclerc F. Validation of the paediatric logistic organ dysfunction (PELOD) score: prospective, observational, multicentre study. Lancet 2003; 362(9379): 192-197.

Mannan-binding lectin in children with Escherichia coli O 157:H7 haemorrhagic colitis and haemolitic uraemia syndrome - Proulx F, Wagner É, Toledano B, Decaluwé H, Seidman EG, Rivard G-É. Mannan-binding lectin in children with Escherichia coli O 157:H7 haemorrhagic colitis and haemolitic uraemia syndrome. Clin Exp Immunol 2003; 133(3): 360-363.

Ventilator-associated pneumonia in intubated children: comparison of different diagnostic methods - Gauvin F, Dassa C, Chaïbou M, Proulx F, Farrell CA, Lacroix J. Ventilator-associated pneumonia in intubated children: comparison of different diagnostic methods. Pediatr Crit Care Med 2003; 4(4): 437-443.

Circulating granulocyte colony-Stimulating factor, C-X-C, and C-C chemokines in children with Escherichia coli O157:H7 associated hemolytic uremic syndrome - Proulx F, Toledano B, Phan V, Clermont MJ, Mariscalco MM, Seidman EG. Circulating granulocyte colony-Stimulating factor, C-X-C, and C-C chemokines in children with Escherichia coli O157:H7 associated hemolytic uremic syndrome. Pediatr Res 2002; 52(6): 928-934.

Le syndrome de défaillance multiviscérale pédiatrique en salle d'urgence - Armano R, Proulx F, Toledano B, Lacroix J. Le syndrome de défaillance multiviscérale pédiatrique en salle d'urgence. Urgence Pratique 2002; 53: 11-14.

An update on pediatric multiple organ dysfunction syndrome - Armano R, Proulx F, Toledano B, Lacroix J. An update on pediatric multiple organ dysfunction syndrome. Recent Res Dev Resp Crit Care Med 2002; 2: 83-101.

Reproductivity of blind protected bronchoalveolar lavage in mechanically-ventilated children - Gauvin F, Lacroix J, Guertin M-C, Proulx F, Farrell CA, Moghrabi A, Lebel P, Dassa C. Reproductivity of blind protected bronchoalveolar lavage in mechanically-ventilated children. Am J Respir Crit Care Med 2002; 165(12): 1618-1623.

Pathogenesis of Shiga toxin-associated hemolytic uremic syndrome - Proulx F, Seidman EG, Karpman D. Pathogenesis of Shiga toxin-associated hemolytic uremic syndrome. Pediatr Res 2001; 50(2): 163-171.

Pediatric sepsis and multiple organ dysfunction syndrome - Despond O, Proulx F, Carcillo J, Lacroix J. Pediatric sepsis and multiple organ dysfunction syndrome. Curr Opin Pediatr 2001; 13(3): 247-253.

Circulating levels of TGF beta-1 and lymphokines among children with hemolytic uremic syndrome - Proulx F, Litalien C, Turgeon J, Mariscalco MM, Seidman EG. Circulating levels of TGF beta-1 and lymphokines among children with hemolytic uremic syndrome. Am J Kidney Dis 2000; 35: 29-34.

Hemolytic uremic syndrome associated with invasive streptococcus pneumoniae infection - Proulx F, Liet JM, David M, Seidman EG, Tapiero B, Robitaille P, Lacroix J. Hemolytic uremic syndrome associated with invasive streptococcus pneumoniae infection. Pediatr Res 2000; 105: 462-463.

Soluble FAS and soluble FAS-ligand in children with Escherichia coli 0157:H7 associated hemolytic uremic syndrome - Masri C, Proulx F, Toledano B, Clermont MJ, Mariscalco MM, Seidman EG, Carcillo J. Soluble FAS and soluble FAS-ligand in children with Escherichia coli 0157:H7 associated hemolytic uremic syndrome. Am J Kidney Dis 2000; 36(4): 687-694.

Leukocytosis in children with Escherichia coli 0157:H7 enteritis developing the hemolytic uremic syndrome - Buteau C, Proulx F, Chaïbou M, Raymond D, Clermont MJ, Mariscalco MM, Lebel MH, Seidman EG. Leukocytosis in children with Escherichia coli 0157:H7 enteritis developing the hemolytic uremic syndrome. Pediatr Infect Dis J 2000; 19(7): 642-647.

Markers of tissue hypoperfusion in pediatric septic shock - Dugas M-A, Proulx F, de Jaegger A, Lacroix J, Lambert MA. Markers of tissue hypoperfusion in pediatric septic shock. Intensive Care Med 2000; 26: 75-83.

Pratiques de transfusion de concentré globulaire en réanimation pédiatrique - Gauvin F, Chaïbou M, Leteurtre S, Toledano B, Hume HA, Proulx F, Hébert P, Martinot A, Leclerc F, Lacroix J. Pratiques de transfusion de concentré globulaire en réanimation pédiatrique. Réan Urg 2000; 9: 339-344.

Of mice and men: Is antibiotic therapy useful in Escherichia coli 0157:147 enteritis? - Proulx F, Seidman EG. Of mice and men: Is antibiotic therapy useful in Escherichia coli 0157:147 enteritis?. Eur J Clin Microbiol Infect Dis 1999; 18: 533-534.

Increased circulating levels of lipopolysaccharide binding protein in children with Escherichia coli 0157:H7 hemorrhagic colitis and hemolytic uremic syndrome - Proulx F, Toledano B, Mariscalco MM, Seidman EG, Carroll SF. Increased circulating levels of lipopolysaccharide binding protein in children with Escherichia coli 0157:H7 hemorrhagic colitis and hemolytic uremic syndrome. Clin Lab Diag Immunol 1999; 6: 773.

Circulating inflammatory cytokine levels predict severity of renal failure in hemolytic uremic syndrome - Litalien C, Proulx F, Mariscalco MM, Robitaille P, Turgeon J, Orrbine E, Rowe C, McLaine PN, Seidman EG. Circulating inflammatory cytokine levels predict severity of renal failure in hemolytic uremic syndrome. Pediatr Nephrol 1999; 13: 840-845.

N-acetycystein in pig liver transplantation - Manika A, Trinh T, Lagacé G, Dugas M-A, Proulx F, Lepage G, Champagne J, Lavoie JC, Cousineau J, Russo P, Chartrand C, Yandza T. N-acetycystein in pig liver transplantation. Transplantation 1999; 68: 327-330.

Development of a pediatric multiple organ dysfunction score. Use of two strategies - Leteurtre S, Martinot A, Duhamel A, Gauvin F, Grandbastien B, Nam TV, Proulx F, Lacroix J. Development of a pediatric multiple organ dysfunction score. Use of two strategies. Med Decis Making 1999; 19: 399-410.

Encéphalite aiguë grave pédiatrique: 14 cas consécutifs - Guerguerian A-M, Tucci M, Toledano B, Farrell CA, Proulx F, Lacroix J. Encéphalite aiguë grave pédiatrique: 14 cas consécutifs. Réan Urg 1999; 8: 395-398.

Le syndrome de défaillance multiviscérale pédiatrique - Proulx F, Dugas M-A, Boeuf B, Lacroix J. Le syndrome de défaillance multiviscérale pédiatrique. Med Ther 1998; 1: 427-433.

Inflammatory mediators in hemorrhagic colitis and hemolytic uremic syndrome - Proulx F, Turgeon J, Litalien C, Mariscalco MM, Robitaille P, Seidman EG. Inflammatory mediators in hemorrhagic colitis and hemolytic uremic syndrome. Pediatr Infect Dis J 1998; 17: 899-904.

Safety of endotracheal Rh-DNAse for treatment of pulmonary atelectasis in mechanically ventilated children - Boeuf B, Proulx F, Morneau S, Marton D, Lacroix J. Safety of endotracheal Rh-DNAse for treatment of pulmonary atelectasis in mechanically ventilated children. Pediatr Pulmonol 1998; 26: 147.

Markers of cellular dysoxia during orthotopic liver transplantation in pigs - de Jaegger A, Proulx F, Yandza T, Dugas M-A, Boeuf B, Manika A, Lacroix J, Lambert MA. Markers of cellular dysoxia during orthotopic liver transplantation in pigs. Intensive Care Med 1998; 24: 268-275.

Clinically significant upper gastrointestinal bleeding acquired in a pediatric intensive care unit: A prospective study - Chaïbou M, Tucci M, Dugas M-A, Farrell CA, Proulx F, Lacroix J. Clinically significant upper gastrointestinal bleeding acquired in a pediatric intensive care unit: A prospective study. Pediatr Res 1998; 102: 933-938.

Innocuité de la Rh DNase (Pulmozyme tm) dans le traitement des atélectasies pulmonaires chez l'enfant ventilé mécaniquement - Proulx F, Morneau S, Marton D, Lacroix J. Innocuité de la Rh DNase (Pulmozyme tm) dans le traitement des atélectasies pulmonaires chez l'enfant ventilé mécaniquement. Réan Urg 1997; 6(6): 709-829.

Pediatric multiple organ dysfunction syndrome - Proulx F, Boeuf B, Lacroix J. Pediatric multiple organ dysfunction syndrome. Intensive Care Med 1997; 14: 79-82.

Simultaneous administration of nitric oxide in two children with pulmonary hypertension - Proulx F, Morneau S, Boeuf B, et al. Simultaneous administration of nitric oxide in two children with pulmonary hypertension. Chest 1997; 112: 569.

Epidemiology of sepsis and multiple organ dysfunction syndrome - Proulx F, Fayon M, Farrell CA, Lacroix J, Gauthier M. Epidemiology of sepsis and multiple organ dysfunction syndrome. Dans: Parillo JE, Balk RA, Calvin JE, Franklin CM, Shapiro BA (eds). Year Book of Critical Care Medicine. St-Louis. Mosby, 1997; 29.

Acquired carnitine abnormalities in critically ill children - Proulx F, Lacroix J, Qureshi IA, Nadeau D, Gauthier M, Lambert MA. Acquired carnitine abnormalities in critically ill children. Eur J Pediatr 1997; 156: 864-869.

Glutathion intra-hépatique et stress oxydatif en transplantation du foie chez le cochon - Yandza T, Manika A, Trinh T, Lavoie JC, Champagne J, Lepage G, Chessex P, Busque S, Proulx F. Glutathion intra-hépatique et stress oxydatif en transplantation du foie chez le cochon. Ann Chir 1997; 51: 839-844.

Blood lactate and gastric intramucosal pH during severe sepsis - Proulx F, Lacroix J, Farrell CA, Gauthier M, Lambert MA. Blood lactate and gastric intramucosal pH during severe sepsis. Crit Care Med 1996; 24: 1092.

Epidemiology of sepsis and multiple organ dysfunction syndrome - Proulx F, Fayon M, Farrell CA, Lacroix J, Gauthier M. Epidemiology of sepsis and multiple organ dysfunction syndrome. Chest 1996; 109: 1033-1037.

Imaging of the fetal heart - Fouron J-C, Drblik SP, van Doesburg NH, Proulx F. Imaging of the fetal heart. Reprod Fertil Dev 1996; 8: 1-9.

Importance de l'observation intrautérine d'une circulation autonome rudimentaire chez un jumeau acardiaque - Pavlova M, Fouron J-C, Lessard M, Proulx F. Importance de l'observation intrautérine d'une circulation autonome rudimentaire chez un jumeau acardiaque. Arch Mal Coeur Vaiss 1996; 89: 629-632.

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