Chercheur

    Emile Levy , M.D. , Ph.D.

    emile.levy@recherche-ste-justine.qc.ca
    Emile Levy
    Axe de recherche
    Santé métabolique et maladies complexes
    Thème de recherche
    Santé cardiométabolique et vasculaire: approches génétiques et environnementales
    Adresse
    CHUSJ - Centre de Recherche

    Téléphone
    514 345-4931 #7783

    Fax
    514 345-4999

    Titres

    • Professeur titulaire, Département de nutrition, Faculté de médecine, Université de Montréal
    • Professeur affilié, Département de pédiatrie, Faculté de médecine, Université de Montréal
    • Professeur affilié, Département d’anatomie et biologie cellulaire, Faculté de médecine, Université de Sherbrooke
    • Membre de la Direction du Centre de recherche du CHU Sainte-Justine
    • Directeur scientifique, Service de gastroentérologie, hépatologie et nutrition
    • Directeur, Unité de lipidologie, métabolisme et nutrition
    • Coordonnateur de l’Axe Nutrition et Santé de l’Institut sur la Nutrition et les Aliments Fonctionnels (INAF) à Québec
    • Membre Fondateur et Vice-Président Scientifique du Réseau International EPODE (Ensemble Prévenons l’Obésité de l’Enfant)
    • Chaire J.A. DeSève de recherche en nutrition

    Formation

    • Études postdoctorales, Service de gastroentérologie, hépatologie et nutrition, CHU Sainte-Justine, 1986
    • PhD, Biochimie clinique et physiologique, Faculté de médecine, Hebrew University, Jérusalem, 1984
    • Complément d'études médicales, École de médecine, Hebrew University, Jérusalem, 1983
    • MSc en biochimie et sciences médicales, Faculté de Médecine, Hebrew University, Jérusalem, 1978
    • BSc en biologie, Faculté de médecine, Hebrew University, Jérusalem, 1974

    Intérêts de recherche

    • Transport des lipides et maladies cardiovasculaires
    • Métabolisme des lipoprotéines, hyperlipidémies et athérosclérose
    • Maladies nutritionnelles (obésité, résistance à l’insuline, diabète de type 2, maladie de Crohn, etc.) et relation avec le stress oxydatif et les acides gras essentiels
    • Ontogenèse et régulation de la synthèse et de la sécrétion des lipoprotéines intestinales
    • Étude moléculaire et cellulaire des malabsorptions intestinales (maladies inflammatoires de l'intestin, fibrose kystique, abêtalipoprotéinémie, hypobêtalipoprotéinémie, rétention de chylomicrons, etc.) et maladies hépatiques
    • Interaction gène-environnement, nutrigénomique, nutrigénétique, maladies comportementales associées aux acides gras essentiels

    Contributions significatives

    • Nous avons documenté l’impact bénéfique des acides gras oméga-3 sur les conséquences du syndrome métabolique tout en précisant leurs actions sur les mécanismes menant aux dyslipidémies postprandiales et à l’athérosclérose (Diabetologia 2006;49:1937-45).
    • Nous avons découvert le gène défectueux dans la maladie de rétention des chylomicrons et d’autres malabsorptions intestinales (Nat Genet 2003;34(1):29-31).
    • Nous avons mis en évidence la contribution de l’intestin à l’hyperlipidémie caractéristique du diabète de type 2 (Diabetes 2003;52:2539-2545).
    • L’assemblage des lipoprotéines riches en triglycérides requiert un processus complexe dont on croyait autrefois qu'il se déroulait exclusivement dans le réticulum endoplasmique. Nous avons été capables d’illustrer la participation active de l’appareil de Golgi dans l’élaboration des lipoprotéines en impliquant des joueurs clés comme le microsomal triglyceride transfer protein (J Biol Chem 2002;277:16470-16477).
    • Nous avons démontré l’impact du polymorphisme relatif à l’intestinal fatty acid binding protein (I-FABP) sur le transport et le métabolisme intracellulaire des lipides, ainsi que sur la lipémie postprandiale dans des conditions de résistance à l’insuline et de diabète de type 2 (JBC 2001;276:39679-39684).

    Sommaire de carrière

    Le docteur Emile Levy est professeur titulaire au Département de nutrition à l’Université de Montréal et directeur scientifique de l’Unité de gastroentérologie, hépatologie et nutrition du CHU Sainte-Justine où il dirige le Laboratoire de lipidologie, métabolisme et nutrition. Il détient depuis 2006 la chaire J.A. DeSève de recherche en nutrition. Ses études menées au cours des 25 années ont considérablement avancé les notions sur les processus digestifs, absorptifs et métaboliques des lipides ainsi que sur les maladies qui leur sont associées chez l’enfant, à savoir les malabsorptions et les maladies inflammatoires de l’intestin, ainsi que les dyslipidémies primaires et secondaires, l’athérosclérose, l’obésité et le diabète de type 2. Le Dr Levy mène aussi des travaux sur la nutrition en utilisant des plateformes nutrigénomiques et protéomiques, dont le but essentiel est de contribuer au développement optimal du nourrisson et de l’enfant.

    Prix et distinctions

    • Nomination à l’Académie Canadienne des Sciences de la Santé, 2011
    • Nomination à l’Académie Nationale de Médecine en France, 2009
    • Prix du mentor scientifique, Club de recherches cliniques du Québec, 2009
    • Prix de carrière scientifique, Fondation des étoiles, 2008
    • Chaire J.A. DeSève de recherche en nutrition, 2006
    • Prix des fondateurs, Société québécoise de lipidologie, métabolisme et nutrition, 2005
    • Prix de la Société européenne des sciences biologiques, Tel Aviv, Israël, 2001
    • Chercheur national, Fonds de la recherche en santé du Québec (FRSQ), 2000-2005
    • Chercheur-boursier Senior 2, FRSQ, 1998-2000
    • Chercheur-boursier Senior 1, FRSQ, 1994-1997
    • Chercheur-boursier Junior 2, FRSQ, 1992-1994
    • Prix Borden, Société canadienne des sciences de la nutrition, 1991
    • Prix d'excellence de recherche en pédiatrie, Conseil des clubs sociaux du Québec, 1990
    • Chercheur-boursier Junior 1, FRSQ, 1988-1991
    • Bourse postdoctorale, FRSQ, 1986-1987
    • Bourse postdoctorale, Fondation canadienne de la fibrose kystique, 1986-1987
    • Bourse d’excellence d'études postdoctorales, Fondation Rothschild, Jérusalem, 1984-1986
    • Prix honorifique, Second Milan International Meeting, Italie, 1984
    • Bourse honorifique, Hebrew University, Jérusalem, 1980-1984
    • Prix honorifique, Association européenne de gastroentérologie, Londres, 1978
    • Bourse honorifique, Hebrew University, Jérusalem, 1976-1978

Publications

Sar1b transgenic male mice are more susceptible to high-fat diet-induced obesity, insulin insensitivity and intestinal chylomicron overproduction - Levy E, Spahis S, Garofalo C, Marcil V, Montoudis A, Sinnett D, Sanchez R, Peretti N, Beaulieu J-F, Sané A. Sar1b transgenic male mice are more susceptible to high-fat diet-induced obesity, insulin insensitivity and intestinal chylomicron overproduction. J Nutr Biochem 2014; 25(5): 540-548.

Circulating docosahexaenoic acid levels are associated with fetal insulin sensitivity - Zhao JP, Levy E, Fraser W, Julien P, Delvin EE, Montoudis A, Spahis S, Garofalo C, Nuyt A-M, Luo ZC. Circulating docosahexaenoic acid levels are associated with fetal insulin sensitivity. PLoS ONE 2014; 9(1): e85054.

AMPK in the small intestine in normal and pathophysiological conditions - Harmel E, Grenier E, Bendjoudi Ouadda A, El Chebly M, Ziv E, Beaulieu J-F, Sané AT, Spahis S, Laville M, Levy E. AMPK in the small intestine in normal and pathophysiological conditions. Endocrinology 2014; 155(3): 873-888.

Intestinal lipid handling: evidence and implication of insulin signaling abnormalities in human obese subjects - Veilleux A, Grenier E, Marceau P, Carpentier A, Richard D, Levy E. Intestinal lipid handling: evidence and implication of insulin signaling abnormalities in human obese subjects. Arterioscler Thromb Vasc Biol 2014; 34(3): 644-653.

Scavenger receptor CD36 mediates inhibition of cholesterol synthesis via activation of the PPAR?/PGC-1a pathway and Insig1/2 expression in hepatocytes - Rodrigue-Way A, Caron V, Bilodeau S, Keil S, Hassan M, Levy E, Mitchell GA, Tremblay A. Scavenger receptor CD36 mediates inhibition of cholesterol synthesis via activation of the PPARγ/PGC-1α pathway and Insig1/2 expression in hepatocytes. FASEB J 2014; 28(4): 1910-1923.

Hepatocyte-specific Ptpn6 deletion promotes hepatic lipid accretion, but reduces NAFLD in diet-induced obesity: Potential role of PPAR? - Xu E, Forest MP, Schwab M, Avramoglu RK, St-Amand E, Caron A, Bellmann K, Shum M, Voisin G, Paquet M, Montoudis A, Levy E, Siminovitch KA, Neel BG, Beauchemin N, Marette A. Hepatocyte-specific Ptpn6 deletion promotes hepatic lipid accretion, but reduces NAFLD in diet-induced obesity: Potential role of PPARγ. Hepatology 2014; (sous presse).

Carotid wall elastography to assess midterm vascular dysfunction secondary to intrauterine growth restriction: Feasibility and comparison with standardized intima-media thickness - Maurice R, Vaujois L, Dahdah NS, Chibab N, Maurice A, Nuyt A-M, Levy E, Bigras JL. Carotid wall elastography to assess midterm vascular dysfunction secondary to intrauterine growth restriction: Feasibility and comparison with standardized intima-media thickness. Ultrasound Med Biol 2014; (sous presse).

Circulating levels of linoleic acid and HDL-cholesterol are major determinants of 4-hydroxynonenal protein adducts in patients with heart failure - Asselin C, Ducharme A, Ntimbane T, Ruiz M, Fortier A, Guertin M-C, Lavoie J, Diaz A, Levy E, Tardif JC, Des Rosiers C. Circulating levels of linoleic acid and HDL-cholesterol are major determinants of 4-hydroxynonenal protein adducts in patients with heart failure. Redox Biol 2014; 2: 148–155.

PCSK9 plays a significant role in cholesterol homeostasis and lipid transport in intestinal epithelial cells - Levy E, Ouadda AB, Spahis S, Sané AT, Garofalo C, Grenier E, Emonnot L, Yara S, Couture P, Beaulieu J-F, Ménard D, Seidah NG, Elchebly M. PCSK9 plays a significant role in cholesterol homeostasis and lipid transport in intestinal epithelial cells. Atherosclerosis 2013; 227(2): 297-306.

Apple peel polyphenols and their beneficial actions on oxidative stress and inflammation - Denis M-C, Furtos A, Dudonné S, Montoudis A, Garofalo C, Desjardins Y, Delvin EE, Levy E. Apple peel polyphenols and their beneficial actions on oxidative stress and inflammation. PLoS ONE 2013; 8(1): e53725.

Iron-ascorbate-mediated lipid peroxidation causes epigenetic changes in the antioxidant defense in intestinal epithelial cells: impact on inflammation - Yara S, Lavoie JC, Beaulieu J-F, Delvin EE, Amre D, Marcil V, Seidman EG, Levy E. Iron-ascorbate-mediated lipid peroxidation causes epigenetic changes in the antioxidant defense in intestinal epithelial cells: impact on inflammation. PLoS ONE 2013; 8(5): e63456.

Maternal and fetal leptin, adiponectin levels and associations with fetal insulin sensitivity - Luo ZC, Nuyt A-M, Delvin EE, Fraser W, Julien P, Audibert F, Girard I, Shatenstein B, Deal C, Grenier E, Garofalo C, Levy E. Maternal and fetal leptin, adiponectin levels and associations with fetal insulin sensitivity. Obesity 2013; 21(1): 210-216.

Association between the PTPN2 gene and Crohn's disease: dissection of potential causal variants - Marcil V, Mack D, Kumar V, Faure C, Carlson CS, Beaulieu P, Israel D, Krupoves A, Costea I, Lambrette P, Grimard G, Dong J, Seidman E, Amre D, Levy E. Association between the PTPN2 gene and Crohn's disease: dissection of potential causal variants. Inflamm Bowel Dis 2013; 19(6): 1149-1155.

Total parenteral nutrition induces sustained hypomethylation of DNA in newborn guinea pigs - Yara S, Levy E, Elremaly W, Rouleau T, Lavoie JC. Total parenteral nutrition induces sustained hypomethylation of DNA in newborn guinea pigs. Pediatr Res 2013; 73(5): 592-595.

Role of the apical and basolateral domains of the enterocyte in the regulation of cholesterol transport by a high glucose concentration - Grenier E, Mailhot G, Dion D, Ravid Z, Spahis S, Bendayan M, Levy E. Role of the apical and basolateral domains of the enterocyte in the regulation of cholesterol transport by a high glucose concentration. Biochem Cell Biol 2013; 91(6): 476-486.

Genome-wide association study signal at the 12q12 locus for Crohn's disease may represent associations with the MUC19 gene - Kumar V, Mack DR, Marcil V, Israel D, Krupoves A, Costea I, Lambrette P, Grimard G, Dong J, Seidman EG, Amre D, Levy E. Genome-wide association study signal at the 12q12 locus for Crohn's disease may represent associations with the MUC19 gene. Inflamm Bowel Dis 2013; 19(6): 1254-1259.

Regional distribution and metabolic effect of PCSK9 insLEU and R46L gene mutations and apoE genotype - Awan Z, Delvin EE, Levy E, Genest J, Davignon J, Seidah NG, Baass A. Regional distribution and metabolic effect of PCSK9 insLEU and R46L gene mutations and apoE genotype. Can J Cardiol 2013; 29(8): 927-933.

Ceacam1 deletion causes vascular alterations in large vessels - Najjar SM, Ledford KJ, Abdallah SL, Paus A, Russo L, Kaw MK, Ramakrishnan SK, Muturi HT, Raphael CK, Lester SG, Heinrich G, Pierre SV, Benndorf R, Kleff V, Jaffa AA, Levy E, Vazquez G, Goldberg IJ, Beauchemin N, Scalia R, Ergün S. Ceacam1 deletion causes vascular alterations in large vessels. Am J Physiol Endocrinol Metab 2013; 305(4): E519-529.

Deleterious effects of indomethacin in the mid-gestation human intestine - Perron N, Tremblay E, Ferretti E, Babakissa C, Seidman EG, Levy E, Ménard D, Beaulieu J-F. Deleterious effects of indomethacin in the mid-gestation human intestine. Genomics 2013; 101(3): 171-177.

Hypertriglyceridemia is associated with insulin levels in adult cystic fibrosis patients - Ishimo MC, Belson L, Ziai S, Levy E, Berthiaume Y, Coderre L, Rabasa-Lhoret R. Hypertriglyceridemia is associated with insulin levels in adult cystic fibrosis patients. J Cystic Fibrosis 2013; 12(3): 271-276.

An atherogenic diet decreases liver FXR gene expression and causes severe hepatic steatosis and hepatic cholesterol accumulation: effect of endurance training - Côté I, Ngo Sock ET, Levy E, Lavoie JM. An atherogenic diet decreases liver FXR gene expression and causes severe hepatic steatosis and hepatic cholesterol accumulation: effect of endurance training. Eur J Nutr 2013; 52(5): 1523-1532.

Modulatory role of PYY in transport and metabolism of cholesterol in intestinal epithelial cells - Grenier E, Garofalo C, Delvin EE, Levy E. Modulatory role of PYY in transport and metabolism of cholesterol in intestinal epithelial cells. PLoS ONE 2012; 7(7): e40992.

Antioxidative properties of paraoxonase 2 in intestinal epithelial cells - Précourt LP, Marcil V, Ntimbane T, Taha R, Lavoie JC, Delvin EE, Seidman E, Beaulieu J-F, Levy E. Antioxidative properties of paraoxonase 2 in intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol 2012; 303(5): G623-634.

Association between genetic variants in the HNF4A gene and childhood-onset Crohn's disease - Marcil V, Sinnett D, Seidman E, Boudreau F, Gendron FP, Beaulieu J-F, Ménard D, Lambert MA, Bitton A, Sanchez R, Amre D, Levy E. Association between genetic variants in the HNF4A gene and childhood-onset Crohn's disease. Genes Immun 2012; 13(7): 556-565.

Regulation of leptin receptor expression in human polarized caco-2/15 cells - Cammisotto P, Bendayan M, Levy E. Regulation of leptin receptor expression in human polarized caco-2/15 cells. Endocr Metab Immune Disord Drug Targets 2012; 12(1): 57-70.

NELL1, NCF4, and FAM92B genes are not major susceptibility genes for Crohn's disease in canadian children and young adults - Amre D, Mack D, Israel D, Krupoves A, Costea I, Lambrette P, Grimard G, Dong J, Levy E. NELL1, NCF4, and FAM92B genes are not major susceptibility genes for Crohn's disease in canadian children and young adults. Inflamm Bowel Dis 2012; 18(3): 529-535.

Maternal and fetal IGF-I and IGF-II levels, fetal growth, and gestational diabetes - Luo ZC, Nuyt A-M, Delvin EE, Audibert F, Girard I, Shatenstein B, Cloutier A, Cousineau J, Djemli A, Deal C, Levy E, Wu Y, Julien P, Fraser W. Maternal and fetal IGF-I and IGF-II levels, fetal growth, and gestational diabetes. J Clin Endocrinol Metab 2012; 97(5): 1720-1728.

Anti-inflammatory effects of epidermal growth factor on the immature human intestine - Ménard D, Tremblay E, Ferretti E, Babakissa C, Perron N, Seidman EG, Levy E, Beaulieu J-F. Anti-inflammatory effects of epidermal growth factor on the immature human intestine. Physiol Genomics 2012; 44(4): 268-280.

Herpes simplex virus-1 infection of colonic explants as a model of viral-induced activation of Crohn's disease - Silva M, Menezes J, Dionne S, Levy E, Amre D, Seidman EG. Herpes simplex virus-1 infection of colonic explants as a model of viral-induced activation of Crohn's disease. J Crohns Colitis 2012; 6(4): 454-463.

Expression and functional analysis of intestinal organic cation/L-carnitine transporter (OCTN) in Crohn's disease - Girardin M, Dionne S, Goyette P, Rioux J, Bitton A, Elimrani I, Charlebois P, Qureshi IA, Levy E, Seidman EG. Expression and functional analysis of intestinal organic cation/L-carnitine transporter (OCTN) in Crohn's disease. J Crohns Colitis 2012; 6(2): 189-197.

Effects of exercise training on molecular markers of lipogenesis and lipid partitioning in fructose-induced liver fat accumulation - Yasari S, Prud'homme D, Tesson F, Jankowski M, Gutkowska J, Levy E, Lavoie JM. Effects of exercise training on molecular markers of lipogenesis and lipid partitioning in fructose-induced liver fat accumulation. J Nutr Metab 2012; 2012: 181687.

Studies on the chemopreventive effect of carnitine on tumorigenesis in vivo, using two experimental murine models of colon cancer - Dionne S, Elimrani I, Roy MJ, Qureshi IA, Sarma DR, Levy E, Seidman EG. Studies on the chemopreventive effect of carnitine on tumorigenesis in vivo, using two experimental murine models of colon cancer. Nutr Cancer 2012; 64(8): 1279-1287.

Les hypocholestérolémies génétiques d'origine intestinale - Peretti N, Di Filippo M, Cueg C, Moulin P, Levy E, Sassolas A. Les hypocholestérolémies génétiques d'origine intestinale. Nutrition & Endocrinologie 2012; 10(57): 15-23.

Association between different growth curve definitions of overweight and obesity and cardiometabolic risk in children - Kakinami L, Henderson M, Delvin EE, Levy E, O'Loughlin J, Lambert MA, Paradis G. Association between different growth curve definitions of overweight and obesity and cardiometabolic risk in children. CMAJ 2012; 184(10): E539-E550.

The mode of administration of total parenteral nutrition and nature of lipid content influence the generation of peroxides and aldehydes - Miloudi K, Comte B, Rouleau T, Montoudis A, Levy E, Lavoie JC. The mode of administration of total parenteral nutrition and nature of lipid content influence the generation of peroxides and aldehydes. Clin Nutr 2012; 31(4): 526-534.

Expression of Sar1b enhances chylomicron assembly and key components of the coat protein complex II system driving vesicle budding - Levy E, Harmel E, Laville M, Sanchez R, Emonnot L, Sinnett D, Ziv E, Delvin EE, Couture P, Marcil V, Sané AT. Expression of Sar1b enhances chylomicron assembly and key components of the coat protein complex II system driving vesicle budding. Arterioscler Thromb Vasc Biol 2011; 31(11): 2692-2699.

Nutrition-related derangements and managements in patients with cystic fibrosis: robust challenges for preventing the development of co-morbidities - Levy E. Nutrition-related derangements and managements in patients with cystic fibrosis: robust challenges for preventing the development of co-morbidities. Clin Biochem 2011; 44(7): 489-490.

Oxidized low-density lipoproteins in cord blood from neonates with intra-uterine growth restriction - Leduc L, Delvin EE, Ouellet A, Garofalo C, Grenier E, Morin L, Dubé J, Bouity-Voubou M, Moutquin JM, Fouron J-C, Klam S, Levy E. Oxidized low-density lipoproteins in cord blood from neonates with intra-uterine growth restriction. Eur J Obstet Gynecol Reprod Biol 2011; 156(1): 46-49.

Long-term effects of prenatal omega-3 fatty acid intake on visual function in school-age children - Jacques C, Levy E, Muckle G, Jacobson SW, Bastien C, Dewailly E, Ayotte P, Jacobson JL, Saint-Amour D. Long-term effects of prenatal omega-3 fatty acid intake on visual function in school-age children. J Pediatr 2011; 158(1): 83-90.

Analysis of the effects of iron and vitamin C co-supplementation on oxidative damage, antioxidant response and inflammation in THP-1 macrophages - Marcil V, Lavoie JC, Emonnot L, Seidman EG, Levy E. Analysis of the effects of iron and vitamin C co-supplementation on oxidative damage, antioxidant response and inflammation in THP-1 macrophages. Clin Biochem 2011; 44(10-11): 873-883.

The three-gene paraoxonase family: Physiologic roles, actions and regulation - Précourt LP, Amre D, Denis M-C, Lavoie JC, Delvin EE, Seidman EG, Levy E. The three-gene paraoxonase family: Physiologic roles, actions and regulation. Atherosclerosis 2011; 214(1): 20-36.

Gene-expression profile analysis in the mid-gestation human intestine discloses greater functional immaturity of the colon as compared with the ileum - Tremblay E, Ferretti E, Babakissa C, Seidman EG, Levy E, Ménard D, Beaulieu J-F, for the Canadian Institutes of Health Research Team on Digestive Epithelium. Gene-expression profile analysis in the mid-gestation human intestine discloses greater functional immaturity of the colon as compared with the ileum. Clin Biochem 2011; 52(6): 670-678.

Early docosahexaenoic acid supplementation of mothers during lactation leads to high plasma concentrations in very preterm infants - Marc I, Plourde M, Lucas M, Sterescu A, Piedboeuf B, Dufresne A, Nuyt A-M, Levy E, Dodin S. Early docosahexaenoic acid supplementation of mothers during lactation leads to high plasma concentrations in very preterm infants. J Nutr 2011; 141(2): 231-236.

A severe form of abetalipoproteinemia caused by new splicing mutations of microsomal triglyceride transfer protein (MTTP) - Pons V, Rolland C, Nauze M, Danjoux M, Gaibelet G, Durandy A, Sassolas A, Levy E, Tercé F, Collet X, Mas E. A severe form of abetalipoproteinemia caused by new splicing mutations of microsomal triglyceride transfer protein (MTTP). Hum Genet 2011; 32(7): 751-759.

Modification in oxidative stress, inflammation and lipoprotein assembly in response to hepatocyte nuclear factor 4 alpha knockdown in intestinal epithelial cells - Marcil V, Seidman E, Sinnett D, Boudreau F, Gendron FP, Beaulieu J-F, Ménard D, Précourt LP, Amre D, Levy E. Modification in oxidative stress, inflammation and lipoprotein assembly in response to hepatocyte nuclear factor 4 alpha knockdown in intestinal epithelial cells. J Biol Chem 2010; 285(52): 40448-40460.

Oxidative stress and mitochondrial functions in the intestinal caco-2/15 cell line - Taha R, Seidman E, Mailhot G, Boudreau F, Gendron FP, Beaulieu J-F, Ménard D, Delvin EE, Amre D, Levy E. Oxidative stress and mitochondrial functions in the intestinal caco-2/15 cell line. PLoS ONE 2010; 5(7): e11817.

Intestinal and hepatic cholesterol carriers in diabetic Psammomys obesus - Levy E, Lalonde G, Delvin EE, Elchebly M, Précourt LP, Seidah NG, Spahis S, Rabasa-Lhoret R, Ziv E. Intestinal and hepatic cholesterol carriers in diabetic Psammomys obesus. Endocrinology 2010; 151(3): 958-970.

Receptor-mediated transcytosis of leptin through human intestinal cells in vitro - Cammisotto P, Bendayan M, Sané AT, Dominguez M, Garofalo C, Levy E. Receptor-mediated transcytosis of leptin through human intestinal cells in vitro. Int J Cell Biol 2010; 2010: 928169.

PPARgamma ligand 15-deoxy-delta 12,14-prostaglandin J2 sensitizes human colon carcinoma cells to TWEAK-induced apoptosis - Dionne S, Levy E, Lévesque D, Seidman E. PPARgamma ligand 15-deoxy-delta 12,14-prostaglandin J2 sensitizes human colon carcinoma cells to TWEAK-induced apoptosis. Anticancer Res 2010; 30(1): 157-166.

CFTR depletion results in changes in fatty acid composition and promotes lipogenesis in intestinal Caco 2/15 cells - Mailhot G, Rabasa-Lhoret R, Moreau A, Berthiaume Y, Levy E. CFTR depletion results in changes in fatty acid composition and promotes lipogenesis in intestinal Caco 2/15 cells. PLoS ONE 2010; 5(5): e10446. Erratum in: PLoS One 2010;5(5) (on line).

Fetal programming of atherosclerosis: Possible role of the mitochondria - Leduc L, Levy E, Bouity-Voubou M, Delvin EE. Fetal programming of atherosclerosis: Possible role of the mitochondria. Eur J Obstet Gynecol Reprod Biol 2010; 149(2): 127-130.

Cross-talk between adipose and gastric leptins for the control of food intake and energy metabolism - Cammisotto P, Levy E, Bukowiecki LJ, Bendayan M. Cross-talk between adipose and gastric leptins for the control of food intake and energy metabolism. Prog Histochem Cyto 2010; 45(3): 143-200.

Guidelines for the diagnosis and management of chylomicron retention disease based on a review of the literature and the experience of two centers - Peretti N, Sassolas A, Roy CC, Deslandres C, Charcosset M, Castagnetti J, Pugnet-Chardon L, Moulin P, Labarge S, Bouthillier L, Lachaux A, Levy E. Guidelines for the diagnosis and management of chylomicron retention disease based on a review of the literature and the experience of two centers. Orphanet J Rare Dis 2010; 5: 24 (on line).

Pédiatrie et obésité: un conflit entre nature et culture, coll. Intervenir - Alvarez F, Levy E, Roy M, e. Pédiatrie et obésité: un conflit entre nature et culture, coll. Intervenir. Éditions du CHU Sainte-Justine, 2010; 208 pages.

Association between genome-wide association studies reported SNPs and pediatric-onset Crohn's disease in Canadian children - Amre D, Mack D, Morgan K, Israel D, Deslandres C, Seidman E, Lambrette P, Costea I, Krupoves A, Feguery H, Dong J, Zhu Z, Grimard G, Levy E. Association between genome-wide association studies reported SNPs and pediatric-onset Crohn's disease in Canadian children. Hum Genet 2010; 128(2): 131-135.

Inhibition of intestinal glucose absorption by anti-diabetic medicinal plants derived from the James Bay Cree traditional pharmacopeia - Nistor Baldea LA, Martineau LC, Benhaddou-Andaloussi A, Arnason JT, Levy E, Haddad PS. Inhibition of intestinal glucose absorption by anti-diabetic medicinal plants derived from the James Bay Cree traditional pharmacopeia. J Ethnopharmacol 2010; 132(2): 473-482.

Hepatocyte nuclear factor-4{alpha} promotes gut neoplasia in mice and protects against the production of reactive oxygen species - Darsigny M, Babeu JP, Seidman E, Gendron FP, Levy E, Carrier J, Perreault N, Boudreau F. Hepatocyte nuclear factor-4{alpha} promotes gut neoplasia in mice and protects against the production of reactive oxygen species. Cancer Res 2010; 70(22): 9423-9433.

Genes involved in the metabolism of poly-unsaturated fatty-acids (PUFA) and risk for Crohn's disease in children & young adults - Costea I, Mack D, Israel D, Morgan K, Krupoves A, Seidman E, Deslandres C, Lambrette P, Grimard G, Levy E, Amre D. Genes involved in the metabolism of poly-unsaturated fatty-acids (PUFA) and risk for Crohn's disease in children & young adults. PLoS ONE 2010; 5(12): e15672.

Maternal glucose tolerance in pregnancy affects fetal insulin sensitivity - Luo ZC, Delvin EE, Fraser W, Audibert F, Deal C, Julien P, Girard I, Shear R, Levy E, Nuyt A-M. Maternal glucose tolerance in pregnancy affects fetal insulin sensitivity. Diabetes Care 2010; 33(9): 2055-2061.

Susceptibility loci reported in genome-wide association studies are associated with Crohn's disease in Canadian children - Amre D, Mack D, Morgan K, Israel D, Deslandres C, Seidman E, Lambrette P, Costea I, Krupoves A, Feguery H, Dong H, Grimard G, Levy E. Susceptibility loci reported in genome-wide association studies are associated with Crohn's disease in Canadian children. Aliment Pharmacol Therap 2010; 31(11): 1186-1191.

Oxysterols in biological systems: the gastrointestinal tract, liver, vascular wall and central nervous system - Garenc C, Julien P, Levy E. Oxysterols in biological systems: the gastrointestinal tract, liver, vascular wall and central nervous system. Free Radic Res 2010; 44(1): 47-73.

Exercise training decreases hepatic SCD-1 gene expression and protein content in rats - Yasari S, Prud'homme D, Wang D, Jankowski M, Levy E, Gutkowska J, Lavoie JM. Exercise training decreases hepatic SCD-1 gene expression and protein content in rats. Mol Cell Biochem 2010; 335(1-2): 291-299.

Ascorbylperoxide contaminating parenteral nutrition perturbs the lipid metabolism in newborn guinea pig - Maghdessian R, Côté F, Rouleau T, Ouadda AB, Levy E, Lavoie JC. Ascorbylperoxide contaminating parenteral nutrition perturbs the lipid metabolism in newborn guinea pig. J Pharmacol Exp Ther 2010; 334(1): 278-284.

Vitamin D status is modestly associated with glycemia and indicators of lipid metabolism in French-Canadian children and adolescents - Delvin EE, Lambert MA, Levy E, O'Loughlin J, Mark S, Gray-Donald K, Paradis G. Vitamin D status is modestly associated with glycemia and indicators of lipid metabolism in French-Canadian children and adolescents. J Nutr 2010; 140(5): 987-991.

Localization, function and regulation of the two intestinal fatty acid-binding protein types - Levy E, Ménard D, Delvin EE, Montoudis A, Beaulieu J-F, Mailhot G, Dubé N, Sinnett D, Seidman E, Bendayan M. Localization, function and regulation of the two intestinal fatty acid-binding protein types. Histochem Cell Biol 2009; 132(3): 351-367.

Functional development of human fetal gastrointestinal tract - Levy E, Delvin EE, Ménard D, Beaulieu J-F. Functional development of human fetal gastrointestinal tract. Dans: Lafond J, Vaillancourt C (eds). Human Embryogenesis: Methods in Molecular Biology. Humana Press, 2009; 205-224.

IL-10 and TNF-alpha promoter haplotypes are associated with childhood Crohn's disease location - Sanchez R, Levy E, Costea F, Sinnett D. IL-10 and TNF-alpha promoter haplotypes are associated with childhood Crohn's disease location. World J Gastroenterol 2009; 15(30): 3776-3782.

Increased hepatic lipogenesis in insulin resistance and Type 2 diabetes is associated with AMPK signalling pathway up-regulation in Psammomys obesus - Ouadda AB, Levy E, Ziv E, Lalonde G, Sané AT, Delvin EE, Elchebly M. Increased hepatic lipogenesis in insulin resistance and Type 2 diabetes is associated with AMPK signalling pathway up-regulation in Psammomys obesus. Bioscience Rep 2009; 29(5): 283-292.

Investigation of reported associations between the 20q13 and 21q22 loci and pediatric-onset Crohn's disease in Canadian children - Amre D, Mack D, Morgan K, Fujiwara M, Israel D, Deslandres C, Seidman E, Lambrette P, Costea I, Krupoves A, Feguery H, Dong J, Grimard G, Levy E. Investigation of reported associations between the 20q13 and 21q22 loci and pediatric-onset Crohn's disease in Canadian children. Am J Gastroenterol 2009; 104(11): 2824-2828.

Chylomicron retention disease: a long term study of two cohorts. - Peretti N, Roy CC, Sassolas A, Deslandres C, Drouin E, Rasquin A, Seidman E, Brochu P, Vohl M-C, Labarge S, Bouvier R, Samson-Bouma ME, Charcosset M, Lachaux A, Levy E. Chylomicron retention disease: a long term study of two cohorts.. Mol Genet Metab 2009; 97(2): 136-142.

Association between insulin, leptin, adiponectin and blood pressure in youth - Lambert MA, O'Loughlin J, Delvin EE, Levy E, Chiolero A, Paradis G. Association between insulin, leptin, adiponectin and blood pressure in youth. J Hypertension 2009; 27(5): 1025-1032.

Plasma PCSK9 is associated with age, sex, and multiple metabolic markers in a population-based sample of children and adolescents - Baass A, Dubuc G, Tremblay M, Delvin EE, O'Loughlin J, Levy E, Davignon J, Lambert MA. Plasma PCSK9 is associated with age, sex, and multiple metabolic markers in a population-based sample of children and adolescents. Clin Chem 2009; 55(9): 1637-1645
.

Omega-3 fatty acid treatment of children with attention-deficit hyperactivity disorder: A randomized, double-blind, placebo-controlled study - Bélanger S, Vanasse M, Spahis S, Sylvestre MP, Lippé S, L'Heureux F, Ghadirian P, Levy E. Omega-3 fatty acid treatment of children with attention-deficit hyperactivity disorder: A randomized, double-blind, placebo-controlled study. Paediatr Child Health 2009; 14(2): 89-98.

CFTR knockdown stimulates lipid synthesis and transport in intestinal CACO-2/15 cells - Mailhot G, Ravid Z, Barchi S, Moreau A, Rabasa-Lhoret R, Levy E. CFTR knockdown stimulates lipid synthesis and transport in intestinal CACO-2/15 cells. Am J Physiol Gastrointest Liver Physiol 2009; 297(6): G1239-1249.

Comparative expression analysis reveals differences in the regulation of intestinal paraoxonase family members - Précourt LP, Seidman E, Delvin EE, Amre D, Deslandres C, Dominguez M, Sinnett D, Levy E. Comparative expression analysis reveals differences in the regulation of intestinal paraoxonase family members. Int J Biochem Cell Biol 2009; 41(7): 1628-1637.

Autophagy gene ATG16L1 but not IRGM is associated with Crohn's disease in Canadian children - Amre D, Mack D, Morgan K, Krupoves A, Costea I, Lambrette P, Grimard G, Dong J, Feguery H, Bucionis V, Deslandres C, Levy E, Seidman EG. Autophagy gene ATG16L1 but not IRGM is associated with Crohn's disease in Canadian children. Inflamm Bowel Dis 2009; 15(4): 501-507.

Interleukin 10 (IL-10) gene variants and susceptibility for pediatric onset Crohn's disease - Amre D, Mack D, Morgan K, Israel D, Lambrette P, Costea I, Krupoves A, Feguery H, Dong J, Grimard G, Deslandres C, Levy E, Seidman EG. Interleukin 10 (IL-10) gene variants and susceptibility for pediatric onset Crohn's disease. Aliment Pharmacol Therap 2009; 29(9): 1025-1031.

Associations between ABCB1/MDR1 gene polymorphisms and Crohn's disease: A gene-wide study in a pediatric population - Krupoves A, Seidman EG, Mack D, Israel D, Morgan K, Lambrette P, Costea I, Deslandres C, Grimard G, Law L, Levy E, Amre D. Associations between ABCB1/MDR1 gene polymorphisms and Crohn's disease: A gene-wide study in a pediatric population. Inflamm Bowel Dis 2009; 15(6): 900-908.

Hindmilk: A headstart in preterm nutrition - Héon M, Goulet C, Levy E, Nuyt A-M. Hindmilk: A headstart in preterm nutrition. Enfermeria Clinica 2009; 19(3): 129-135.

Regulation of the proprotein convertase subtilisin/kexin type 9 in intestinal epithelial cells - Leblond F, Seidah N, Précourt LP, Delvin EE, Dominguez M, Levy E. Regulation of the proprotein convertase subtilisin/kexin type 9 in intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol 2009; 296(4): G805-815.

Targeted disruption of carcinoembryonic antigen-related cell adhesion molecule 1 promotes diet-induced hepatic steatosis and insulin resistance - Xu E, Dubois MJ, Leung N, Charbonneau A, Turbide C, Avramoglu RK, DeMarte L, Elchebly M, Streichert T, Levy E, Beauchemin N, Marette A. Targeted disruption of carcinoembryonic antigen-related cell adhesion molecule 1 promotes diet-induced hepatic steatosis and insulin resistance. Endocrinology 2009; 150(8): 3503-3512.

Effects of exercise training on hepatic microsomal triglyceride transfer protein content in rats - Chapados C, Seelaender M, Levy E, Lavoie JM. Effects of exercise training on hepatic microsomal triglyceride transfer protein content in rats. Horm Metab Res 2009; 41(4): 287-293
.

Dichotomy between postprandial glucose and lipid profiles in adults with cystic fibrosis: a pilot study - Hammana I, Coderre L, Potvin S, Costa M, Berthiaume Y, Lavoie A, Chiasson JL, Levy E, Rabasa-Lhoret R. Dichotomy between postprandial glucose and lipid profiles in adults with cystic fibrosis: a pilot study. J Cystic Fibrosis 2009; 8(2): 128-134.

Fish oil and argan oil intake differently modulate insulin resistance and glucose intolerance in a rat model of dietary-induced obesity - Samane S, Christon R, Dombrowski L, Turcotte S, Charrouf Z, Lavigne C, Levy E, Bachelard H, Amarouch H, Marette A, Haddad PS. Fish oil and argan oil intake differently modulate insulin resistance and glucose intolerance in a rat model of dietary-induced obesity. Metabolism 2009; 58(7): 909-919.

In vitro studies on the inhibition of colon cancer by butyrate and carnitine - Roy MJ, Dionne S, Marx G, Qureshi IA, Sarma DSR, Levy E, Seidman EG. In vitro studies on the inhibition of colon cancer by butyrate and carnitine. Nutrition 2009; 25(11-12): 1193-1201.

Cystic fibrosis-related diabetes: from CFTR dysfunction to oxidative stress - Ntimbane T, Comte B, Mailhot G, Berthiaume Y, Poitout V, Prentki M, Rabasa-Lhoret R, Levy E. Cystic fibrosis-related diabetes: from CFTR dysfunction to oxidative stress. Clin Biochem Rev 2009; 30(4): 153–177.

Loss of hepatocyte-nuclear-factor-4alpha affects colonic ion transport and causes chronic inflammation resembling inflammatory bowel disease in mice - Darsigny M, Babeu JP, Dupuis A, Furth EE, Seidman EG, Levy E, Verdu EF, Gendron FP, Boudreau F. Loss of hepatocyte-nuclear-factor-4alpha affects colonic ion transport and causes chronic inflammation resembling inflammatory bowel disease in mice. PLoS ONE 2009; 4(10): e7609.

CFTR knockdown stimulates lipid synthesis and transport in intestinal Caco-2/15 cells - Mailhot G, Ravid Z, Barchi S, Moreau A, Rabasa-Lhoret R, Levy E. CFTR knockdown stimulates lipid synthesis and transport in intestinal Caco-2/15 cells. Am J Physiol Gastrointest Liver Physiol 2009; 297(6): G1239-1249.

Cystic fibrosis-related diabetes: from CFTR dysfunction to oxidative stress - Ntimbane T, Comte B, Mailhot G, Berthiaume Y, Poitout V, Prentki M, Rabasa-Lhoret R, Levy E. Cystic fibrosis-related diabetes: from CFTR dysfunction to oxidative stress. Clin Biochem Rev 2009; 30(4): 153–177.

Fish oil in the gastrointestinal tract: emphasis on functional and inflammation and potential efficacy in chronic disorders - Levy E, Spahis S. Fish oil in the gastrointestinal tract: emphasis on functional and inflammation and potential efficacy in chronic disorders. Dans: Heikkinen EP (ed.). Fish Oils and Health. Nova Publisher, 2008; 185-196.

Dietary patterns and risk for Crohn’s disease in children - D'Souza S, Levy E, Mack D, Israel D, Lambrette P, Ghadirian P, Deslandres C, Morgan K, Seidman EG, Amre D. Dietary patterns and risk for Crohn’s disease in children. Inflamm Bowel Dis 2008; 14(3): 367-373.

Anderson or chylomicron retention disease: Molecular impact of five mutations in the SAR1B gene on the structure and the functionality of Sar1b protein - Charcosset M, Sassolas A, Peretti N, Roy CC, Deslandres C, Sinnett D, Levy E, Lachaux A. Anderson or chylomicron retention disease: Molecular impact of five mutations in the SAR1B gene on the structure and the functionality of Sar1b protein. Mol Genet Metab 2008; 93(1): 74-84.

Association between cigarette smoking and C-reactive protein in a representative, population-based sample of adolescents - O'Loughlin JL, Lambert MA, Karp I, McGrath J, Gray-Donald K, Barnett T, Delvin EE, Levy E, Paradis G. Association between cigarette smoking and C-reactive protein in a representative, population-based sample of adolescents. Nicotine Tob Res 2008; 10(3): 525-532.

Intestinal fatty acid binding protein regulates mitochondrion beta-oxidation and cholesterol uptake - Montoudis A, Seidman EG, Boudreau F, Beaulieu J-F, Ménard D, Elchebly M, Mailhot G, Sané AT, Lambert MA, Delvin EE, Levy E. Intestinal fatty acid binding protein regulates mitochondrion beta-oxidation and cholesterol uptake. J Lipid Res 2008; 49(5): 961-972.

Oxidative stress and cystic fibrosis-related diabetes: A pilot study in children - Ntimbane T, Krishnamoorthy P, Huot C, Legault L, Jacob S, Brunet S, Levy E, Guéraud F, Lands LC, Comte B. Oxidative stress and cystic fibrosis-related diabetes: A pilot study in children. J Cystic Fibrosis 2008; 7(5): 373-384.

Prevalence of cardiometabolic risk factors by weight status in a population-based sample of Quebec children and adolescents - Lambert MA, Delvin EE, Levy E, O'Loughlin JL, Paradis G, Barnett T, McGrath J. Prevalence of cardiometabolic risk factors by weight status in a population-based sample of Quebec children and adolescents. Can J Cardiol 2008; 24(7): 575-583.

Low vitamin D status in a representative sample of youth from Québec, Canada - Mark S, Gray-Donald K, Delvin EE, O'Loughlin JL, Paradis G, Levy E, Lambert MA. Low vitamin D status in a representative sample of youth from Québec, Canada. Clin Chem 2008; 54(8): 1283-1289.

Investigation of associations between the pregnane-X receptor gene (NR1I2) and Crohn's disease in Canadian children using a gene-wide haplotype-based approach - Amre D, Mack D, Israel D, Morgan K, Krupoves A, Costea I, Lambrette P, Grimard G, Deslandres C, Levy E, Seidman EG. Investigation of associations between the pregnane-X receptor gene (NR1I2) and Crohn's disease in Canadian children using a gene-wide haplotype-based approach. Inflamm Bowel Dis 2008; 14(9): 1214-1218.

Reduced brain choline in homocystinuria due to remethylation defects - Debray FG, Boulanger Y, Khiat A, Décarie JC, Orquin J, Roy M-S, Lortie A, Ramos F, Verhoeven NM, Struys E, Blom HJ, Jakobs C, Levy E, Mitchell GA, Lambert MA. Reduced brain choline in homocystinuria due to remethylation defects. Neurology 2008; 71(1): 44-49.

Modulation of intestinal cholesterol absorption by high glucose levels: impact on cholesterol transporters, regulatory enzymes and transcription factors - Ravid Z, Bendayan M, Delvin EE, Sané AT, Elchebly M, Lafond J, Lambert MA, Mailhot G, Levy E. Modulation of intestinal cholesterol absorption by high glucose levels: impact on cholesterol transporters, regulatory enzymes and transcription factors. Am J Physiol Regul Integr Comp Physiol 2008; 295(5): G873-885.

Effect of oxydative stress on the status of adhesion molecules, nuclear receptors and cholesterol flux in endothelial cells: priming of monocytes - Marcil V, Delvin EE, Amre D, Sinnett D, Geneviève M, Seidman EG, Levy E. Effect of oxydative stress on the status of adhesion molecules, nuclear receptors and cholesterol flux in endothelial cells: priming of monocytes. Clin Med Cardiol 2008; 2: 215-218.

Modulation of placental protein expression of OLR1: implication in pregnancy-related disorders or pathologies - Ethier-Chiasson M, Forest JC, Giguere Y, Masse A, Marseille-Tremblay C, Levy E, Lafond J. Modulation of placental protein expression of OLR1: implication in pregnancy-related disorders or pathologies. Reproduction 2008; 136(4): 491-502.

Lipid profile, fatty acid composition and pro- and anti-oxidant status in pediatric patients with attention-deficit/hyperactivity disorder - Spahis S, Vanasse M, Bélanger S, Ghadirian P, Grenier E, Levy E. Lipid profile, fatty acid composition and pro- and anti-oxidant status in pediatric patients with attention-deficit/hyperactivity disorder. Prostaglandins Leukot Essent Fatty Acids 2008; 79(1-2): 47-53.

Associations between genetic variants in the IL23R gene and early-onset Crohn’s disease. Results from a case-control and family-based study among Canadian children - Amre D, Mack D, Israel D, Morgan K, Lambrette P, Law L, Grimard G, Deslandres C, Krupoves A, Bucionis V, Costea I, Bissonauth V, Feguery H, D'Souza S, Levy E, Seidman EG. Associations between genetic variants in the IL23R gene and early-onset Crohn’s disease. Results from a case-control and family-based study among Canadian children. Am J Gastroenterol 2008; 103(3): 615-620.

Abnormal hepatobiliary and circulating lipid metabolism in the Long-Evans Cinnamon rat model of Wilson's disease - Levy E, Brunet S, Alvarez F, Seidman EG, Bouchard G, Escobar E, Martin S. Abnormal hepatobiliary and circulating lipid metabolism in the Long-Evans Cinnamon rat model of Wilson's disease. Life Sci 2007; 80(16): 1472-1483.

Intestinal cholesterol transport proteins: an update and beyond - Levy E, Spahis S, Sinnett D, Peretti N, Maupas-Schwalm F, Delvin EE, Lambert MA, Lavoie M. Intestinal cholesterol transport proteins: an update and beyond. Curr Opin Lipidol 2007; 18(3): 310-318.

Biological role, protein expression, subcellular localization and oxidative stress response of paraoxonase 2 in the intestine of humans and rats - Levy E, Trudel K, Bendayan M, Seidman EG, Delvin EE, Elchebly M, Lavoie JC, Précourt LP, Amre D, Sinnett D. Biological role, protein expression, subcellular localization and oxidative stress response of paraoxonase 2 in the intestine of humans and rats. Am J Physiol Gastrointest Liver Physiol 2007; 293(6): G1252-1261.

[Teasing out the various factors associated with the digestive and absorptive phases of intestinal transport] - Levy E, Lavoie M, Delvin EE, Seidman EG, Lambert MA, Sinnett D, Sané AT, Leblond F, Spahis S, Roy CC. [Teasing out the various factors associated with the digestive and absorptive phases of intestinal transport]. Méd Sci (Paris) 2007; 23(11): 1014-1019.

[Brief history of the Ste-Justine Hospital Research Centre] - Levy E, Roy CC. [Brief history of the Ste-Justine Hospital Research Centre]. Médecine Sciences 2007; 23(11): 901-903.

Fatty acid composition in postmortem brains of people who completed suicide - Lalovic A, Levy E, Canetti L, Sequeira A, Montoudis A, Turecki G. Fatty acid composition in postmortem brains of people who completed suicide. J Psychiat Neurosci 2007; 32(5): 363-370.

Cholesterol content in brains of suicide completers - Lalovic A, Levy E, Luheshi G, Canetti L, Grenier E, Sequeira A, Turecki G. Cholesterol content in brains of suicide completers. Int J Neuropsychopharmacol 2007; 10(2): 159-166.

Prevalence and clinical phenotype of the p.Val226Met glucokinase gene mutation in French Canadians in Quebec, Canada - Henderson M, Levy E, Delvin EE, Loosekoot M, Lambert MA. Prevalence and clinical phenotype of the p.Val226Met glucokinase gene mutation in French Canadians in Quebec, Canada. Mol Genet Metab 2007; 90(1): 87-92.

Asymmetrical regulation of scavenger receptor class B type I by apical and basolateral stimuli using Caco-2 cells - Peretti N, Delvin EE, Sinnett D, Marcil V, Garofalo C, Levy E. Asymmetrical regulation of scavenger receptor class B type I by apical and basolateral stimuli using Caco-2 cells. J Cell Biochem 2007; 100(2) : 421-433 .

Mesangiolipidosis in Alagille syndrome--relationship with apolipoprotein A-I - Benoit G, Sartelet H, Levy E, Boule ME, Alvarez F, Abed L, Mérouani A. Mesangiolipidosis in Alagille syndrome--relationship with apolipoprotein A-I. Nephrol Dial Transpl 2007; 22(7): 2072-2075.

Imbalances in dietary consumption of fatty acids, vegetables, and fruits are associated with risk for Crohn's disease in children - Amre D, D'Souza S, Morgan K, Seidman EG, Lambrette P, Grimard G, Israel D, Mack D, Ghadirian P, Deslandres C, Chotard V, Budai B, Law L, Levy E, Seidman EG. Imbalances in dietary consumption of fatty acids, vegetables, and fruits are associated with risk for Crohn's disease in children. Am J Gastroenterol 2007; 102(9): 2016-2025.

Quantitative analysis of a proteome by N-terminal stable-isotope labelling of tryptic peptides - Fediaev M, Trudel S, Tjon-A-Pan N, Parmar A, Posner BI, Levy E, Nifantiev I, Pshezhetsky AV. Quantitative analysis of a proteome by N-terminal stable-isotope labelling of tryptic peptides. Rapid Commun Mass Spectrom 2007; 21(16): 2671-2679.

Subcellular proteomics of cell differententiation: Quantitative analysis of the plasma membrane protein of Caco-2 cells - Pshezhetsky AV, Fediaev M, Ashmarina L, Mazur A, Budman L, Sinnett D, Labuda D, Beaulieu J-F, Ménard D, Nifantiev I, Levy E. Subcellular proteomics of cell differententiation: Quantitative analysis of the plasma membrane protein of Caco-2 cells. Proteomics 2007; 7(13): 2201-2215.

[Is it justifiable to administrate vitamin A, E and D for 6 months in the premature infants?] - Salle BL, Delvin EE, Claris O, Hascoët M, Levy E. [Is it justifiable to administrate vitamin A, E and D for 6 months in the premature infants?]. Arch Pediatr 2007; 14(12): 1408-1412.

Effect of retinoic acid on cell proliferation and differentiation as well as on lipid synthesis, lipoprotein secretion, and apolipoprotein biogenesis - Grenier E, Maupas-Schwalm F, Beaulieu J-F, Seidman EG, Delvin EE, Sané AT, Tremblay E, Garofalo C, Levy E. Effect of retinoic acid on cell proliferation and differentiation as well as on lipid synthesis, lipoprotein secretion, and apolipoprotein biogenesis. Am J Physiol Gastrointest Liver Physiol 2007; 293(6): G1178-1189.

Overproduction of intestinal lipoprotein containing apolipoprotein B-48 in Psammomys obesus: impact of dietary n-3 fatty acids - Levy E, Spahis S, Ziv E, Marette A, Elchebly M, Lambert MA, Delvin EE. Overproduction of intestinal lipoprotein containing apolipoprotein B-48 in Psammomys obesus: impact of dietary n-3 fatty acids. Diabetologia 2006; 49(8): 1937-1945.

Paraoxonase 1, 2 and 3 DNA variants and susceptibility to childhood inflammatory bowel disease - del Rocio Sanchez Garcia M, Levy E, Seidman EG, Amre D, Costea F, Sinnett D. Paraoxonase 1, 2 and 3 DNA variants and susceptibility to childhood inflammatory bowel disease. Gut 2006; 55(12): 1820-1821.

Short chain fatty acids: are they ready for prime time? - Roy CC, Levy E, Bouthillier L, Kien L. Short chain fatty acids: are they ready for prime time?. Nutr Clin Pract 2006; 21(4): 351-366.

The effect of calcium antagonists onlipid synthesis and secretion in HTC cells - Ciubotariu I, Levy E, Haddad PS. The effect of calcium antagonists onlipid synthesis and secretion in HTC cells. Biologie et santé 2006; 6(1): 1-12.

La recherche infirmière en milieu clinique. L'expérience du CHU mère-enfant Hôpital Ste-Justine - Goulet C, Ward L, Levy E, Colin C. La recherche infirmière en milieu clinique. L'expérience du CHU mère-enfant Hôpital Ste-Justine. Recherche Soins Inf 2006; 84: 84-90.

Abnormal intracellular lipid processing contributes to fat malabsorption in cystic fibrosis patients - Peretti N, Roy CC, Drouin E, Seidman EG, Brochu P, Casimir G, Levy E. Abnormal intracellular lipid processing contributes to fat malabsorption in cystic fibrosis patients. Am J Physiol Gastrointest Liver Physiol 2006; 290(4): G609-615.

Adenoviral-mediated modulation of Sim1 expression in the paraventricular nucleus affects food intake - Yang C, Gagnon D, Vachon P, Tremblay A, Levy E, Massie B, Michaud JL. Adenoviral-mediated modulation of Sim1 expression in the paraventricular nucleus affects food intake. J Neurosci 2006; 26(26): 7116-7120.

Adiponectin, adiposity and insulin resistance in children and adolescents - Punthakee Z, Delvin EE, O'Loughlin JL, Paradis G, Levy E, Platt RW, Lambert MA. Adiponectin, adiposity and insulin resistance in children and adolescents. J Clin Endocrinol Metab 2006; 91(6): 2119-2125.

Intestinal fatty acid binding protein and lipid transport in human intestinal epithelial cells - Montoudis A, Delvin EE, Ménard D, Beaulieu J-F, Jean D, Tremblay E, Bendayan M, Levy E. Intestinal fatty acid binding protein and lipid transport in human intestinal epithelial cells. Biochem Biophys Res Commun 2006; 339: 248-254.

Localization and role of NPC1L1 in cholesterol absorption in human intestine - Sané AT, Sinnett D, Delvin EE, Bendayan M, Marcil V, Ménard D, Beaulieu J-F, Levy E. Localization and role of NPC1L1 in cholesterol absorption in human intestine. J Lipid Res 2006; 47(10): 2112-2120.

Oxidative stress influences cholesterol efflux in THP-1 macrophages: Role of ATP-binding cassette A1 and nuclear factors - Marcil V, Delvin EE, Sané AT, Tremblay A, Levy E. Oxidative stress influences cholesterol efflux in THP-1 macrophages: Role of ATP-binding cassette A1 and nuclear factors. Cardiovasc Res 2006; 72(3): 473-482.

Gene expression profiles of normal proliferative and differentiating human intestinal epithelial cells: a comparison with the Caco-2 cell model - Tremblay E, Auclair J, Delvin EE, Levy E, Ménard D, Pshezhetsky AV, Rivard N, Seidman EG, Sinnett D, Vachon PH, Beaulieu J-F. Gene expression profiles of normal proliferative and differentiating human intestinal epithelial cells: a comparison with the Caco-2 cell model. J Cell Biochem 2006; 99(4) : 1175-1186.

Effect of different surfactants in biorelevant medium on the secretion of a lipophilic compound in lipoproteins using Caco-2 cell culture - Karpt DM, Holm R, Garofalo C, Levy E, Jacobsen J, Mullertz A. Effect of different surfactants in biorelevant medium on the secretion of a lipophilic compound in lipoproteins using Caco-2 cell culture. J Pharm Sci 2006; 95(1): 45-55.

Secretion of soluble leptin receptors by exocrine and endocrine cells of the gastric mucosa - Cammisotto PG, Gingras D, Renaud C, Levy E, Bendayan M. Secretion of soluble leptin receptors by exocrine and endocrine cells of the gastric mucosa. Am J Physiol Gastrointest Liver Physiol 2006; 290(2): G242-249.

Distribution of LDL particle size in a population-based sample of children and adolescents and relationship with other cardiovascular risk ractors - Stan S, Levy E, Delvin EE, Hanley JA, Lamarche B, O'Loughlin JL, Paradis G, Lambert MA. Distribution of LDL particle size in a population-based sample of children and adolescents and relationship with other cardiovascular risk ractors. Clin Chem 2005; 51(7): 1192-1200.

Mechanisms of lipid malabsorption in cystic fibrosis: the impact of essential fatty acids deficiency - Peretti N, Marcil V, Drouin E, Levy E. Mechanisms of lipid malabsorption in cystic fibrosis: the impact of essential fatty acids deficiency. Nutr Metab 2005; 3(2): 11.

Endocrine and exocrine secretion of leptin by the gastric mucosa - Cammisotto PG, Renaud C, Gingras D, Delvin EE, Levy E, Bendayan M. Endocrine and exocrine secretion of leptin by the gastric mucosa. J Histochem Cytochem 2005; 53(7): 851-860.

Iron-ascorbic-induced oxidant stress and its quenching by paraoxonase I in HDL and the liver: Comparison between humans and rats - Trudel K, Sinnett D, James RW, Delvin EE, Amre D, Seidman EG, Levy E. Iron-ascorbic-induced oxidant stress and its quenching by paraoxonase I in HDL and the liver: Comparison between humans and rats. J Cell Biochem 2005; 96(2): 404-411.

Intestinal fatty acid binding protein and microsomal triglyceride transfer protein polymorphisms in French-Canadian youth - Stan S, Lambert MA, Delvin EE, Paradis G, O'Loughlin JL, Lavallée C, Hanley JA, Levy E. Intestinal fatty acid binding protein and microsomal triglyceride transfer protein polymorphisms in French-Canadian youth. J Lipid Res 2005; 46(2): 320-327.

Oral vitamin A, E and D supplementation of pre-term newborns either breast-fed or formula-fed: a 3-month longitudinal study - Delvin EE, Salle BL, Claris O, Putet G, Hascoët M, Desnoulez L, Messai S, Levy E. Oral vitamin A, E and D supplementation of pre-term newborns either breast-fed or formula-fed: a 3-month longitudinal study. J Pediatr Gastroenterol Nutr 2005; 40(1): 43-47.

Reduced bile flow associated with parenteral nutrition is independent of oxidant load and parenteral multivitamins - Lavoie JC, Chessex P, Gauthier C, Levy E, Alvarez F, St-Louis P, Rouleau T. Reduced bile flow associated with parenteral nutrition is independent of oxidant load and parenteral multivitamins. J Pediatr Gastroenterol Nutr 2005; 41(1): 108-114.

Ontogeny, immunolocalisation, distribution and function of SR-BI in the human intestine - Levy E, Ménard D, Suc I, Delvin EE, Seidman EG, Marcil V, Brissette L, Thibault L, Bendayan M. Ontogeny, immunolocalisation, distribution and function of SR-BI in the human intestine. J Cell Sci 2004; 177(Pt 2): 327-337.

Genetic diversity patterns in the SR-BI/II locus can be explained by a recent selective sweep - Le Jossec M, Wambach T, Labuda D, Sinnett D, Levy E. Genetic diversity patterns in the SR-BI/II locus can be explained by a recent selective sweep. Mol Biol Evol 2004; 21(4): 760-769.

New lipids in enteral feeding - Roy CC, Bouthillier A, Seidman EG, Levy E. New lipids in enteral feeding. Curr Opin Clin Nutr Metab Care 2004; 7(2): 117-122.

Both insulin resistance and diabetes in Psammomys obesus upregulate the hepatic machinery involved in intracellular VLDL assembly - Zoltowska M, Ziv E, Delvin EE, Lambert MA, Seidman EG, Levy E. Both insulin resistance and diabetes in Psammomys obesus upregulate the hepatic machinery involved in intracellular VLDL assembly. Arterioscler Thromb Vasc Biol 2004; 24(1): 118-123.

The >D15 kb deletion French Canadian founder mutation in familial hypercholesterolemia: rapid PCR-based diagnostic assay and prevalence in Québec - Simard LR, Viel J, Lambert MA, Paradis G, Levy E, Delvin EE, Mitchell GA. The >D15 kb deletion French Canadian founder mutation in familial hypercholesterolemia: rapid PCR-based diagnostic assay and prevalence in Québec. Clin Genet 2004; 65(3): 202-208.

Usefulness of the american academy of pediatrics recommendations for identifying youths with hypercholesterolemia - O'Loughlin JL, Lauzon B, Paradis G, Hanley JA, Levy E, Delvin EE, Lambert MA. Usefulness of the american academy of pediatrics recommendations for identifying youths with hypercholesterolemia. Pediatr Res 2004; 113(6): 1723-1727.

Insulin resistance syndrome in a representative sample of children and adolescents from Quebec, Canada - Lambert MA, Paradis G, O'Loughlin JL, Delvin EE, Hanley JA, Levy E. Insulin resistance syndrome in a representative sample of children and adolescents from Quebec, Canada. Int J Obes Relat Metab Disord 2004; 28(7): 833-841.

Impact of in vivo glycation of LDL on platelet aggregation and monocyte chemotaxis in diabetic Psammomys obesus - Zoltowska M, Delvin EE, Ziv E, Peretti N, Levy E. Impact of in vivo glycation of LDL on platelet aggregation and monocyte chemotaxis in diabetic Psammomys obesus. Lipids 2004; 39(1): 81-85.

The temporal relationship between the onset of type 1 diabetes and celiac disease: a study based on immunoglobulin a antitransglutaminase screening - Peretti N, Bienvenu D, Bouvet C, Fabien C, Tixier F, Thivolet C, Levy E, Lachaux A, Nicolino M. The temporal relationship between the onset of type 1 diabetes and celiac disease: a study based on immunoglobulin a antitransglutaminase screening. Pediatr Res 2004; 113(5): E418-E422.

Hormone-sensitive lipase deficiency in mice: lipid energy homeostasis during fasting, beta adrenergic stimulation and dietary fat loading - Fortier M, Wang S, Mfuma L, Semache M, Li H, Levy E, Richard D, Mitchell GA. Hormone-sensitive lipase deficiency in mice: lipid energy homeostasis during fasting, beta adrenergic stimulation and dietary fat loading. Am J Physiol Endocrinol Metab 2004; 287(2): E282-288.

Identification of microsomal tryglyceride transfer protein in intestinal brush-border membrane - Slight I, Bendayan M, Malo C, Delvin EE, Lambert MA, Levy E. Identification of microsomal tryglyceride transfer protein in intestinal brush-border membrane. Exp Cell Res 2004; 300(1): 11-22.

Blood pressure and adiposity in children and adolescents - Paradis G, Lambert MA, O'Loughlin JL, Lavallée C, Aubin J, Delvin EE, Levy E, Hanley JA. Blood pressure and adiposity in children and adolescents. Circulation 2004; 110(13): 1832-1838.

C-reactive protein and features of the metabolic syndrome in a population-based sample of children and adolescents - Lambert MA, Delvin EE, Paradis G, O'Loughlin JL, Hanley JA, Levy E. C-reactive protein and features of the metabolic syndrome in a population-based sample of children and adolescents. Clin Chem 2004; 50(10): 1762-1768.

Estrogen-related receptor alpha (ERRalpha) is a transcriptional regulator of apolipoprotein A-IV and controls lipid handling in the intestine - Carrier J, Deblois G, Champigny C, Levy E, Giguère V. Estrogen-related receptor alpha (ERRalpha) is a transcriptional regulator of apolipoprotein A-IV and controls lipid handling in the intestine. J Biol Chem 2004; 279(50): 52052-52058.

Regard sur les processus digestifs et absorptifs des lipides alimentaires - Marcil V, Peretti N, Delvin EE, Levy E. Regard sur les processus digestifs et absorptifs des lipides alimentaires. Gastroenterol Clin Biol 2004; 28(12): 1257-1266.

Combined effects of essential fatty acid deficiency and tumor necrosis factor-a on circulating lipoproteins in rats - Levy E, Delvin EE, Peretti N, Bouchard G, Seidman EG. Combined effects of essential fatty acid deficiency and tumor necrosis factor-a on circulating lipoproteins in rats. Lipids 2003; 38(6): 595-602.

Hyperlipidemic profiles during remission in childhood idiopathic nephrotic syndrome - Mérouani A, Levy E, Mongeau J-G, Robitaille P, Lambert MA, Delvin EE. Hyperlipidemic profiles during remission in childhood idiopathic nephrotic syndrome. Clin Biochem 2003; 36(7): 571-574.

Small babies receive the cardiovascular protective apoliprotein epsilon 2 allele less frequently than expected - Infante-Rivard C, Levy E, Rivard G-É, Guinguet M, Feoli-Fonseca J-C. Small babies receive the cardiovascular protective apoliprotein epsilon 2 allele less frequently than expected. J Med Genet 2003; 40(8): 626-629.

Vascular responses to alpha adrenergic stimulation and depolarization are enhanced in insulin-resistant and diabetic Psammonys Obesus - Zoltowska M, St-Louis J, Ziv E, Sicotte B, Delvin EE, Levy E. Vascular responses to alpha adrenergic stimulation and depolarization are enhanced in insulin-resistant and diabetic Psammonys Obesus. Can J Physiol Pharmacol 2003; 81(7): 704-710.

Inflammatory reaction without endogenous antioxidant response in caco-2 cells exposed to iron/ascorbate-mediated lipid peroxidation - Bernotti S, Seidman EG, Sinnett D, Brunet S, Dionne S, Delvin EE, Levy E. Inflammatory reaction without endogenous antioxidant response in caco-2 cells exposed to iron/ascorbate-mediated lipid peroxidation. Am J Physiol Gastrointest Liver Physiol 2003; 285(5): G898-G906.

Membrane peroxidation by lipopolysaccharide and iron/ascorbate adversely affects Caco-2 cell function : Beneficial role of butyric acid - Courtois F, Seidman EG, Delvin EE, Asselin C, Bernotti S, Ledoux M, Levy E. Membrane peroxidation by lipopolysaccharide and iron/ascorbate adversely affects Caco-2 cell function : Beneficial role of butyric acid. Am J Clin Nutr 2003; 77(3): 744-750.

Effects of dietary soybean lecithin on plasma lipid transport and hepatic cholesterol metabolism in rats - LeBlanc MJ, Brunet S, Bouchard G, Lamireau D, Yousef IM, Gavigno V, Levy E, Tuchweber B. Effects of dietary soybean lecithin on plasma lipid transport and hepatic cholesterol metabolism in rats. J Nutr Biochem 2003; 14(1): 40-48.

Butyrate induced Caco 2 cell apoptosis is mediated via the mitochondrial pathway - Ruemmele F, Schwartz S, Seidman EG, Dionne S, Levy E, Lentze MJ. Butyrate induced Caco 2 cell apoptosis is mediated via the mitochondrial pathway. Gut 2003; 52(1): 94-100.

Circulating bile-salt-dependent lipase originates from the pancreas via intestinal transcytosis - Bruneau N, Bendayan M, Gringras D, Ghitescu L, Levy E, Lombardo D. Circulating bile-salt-dependent lipase originates from the pancreas via intestinal transcytosis. Gastroenterology 2003; 124(2): 470-480.

Oxidative tyrosylation of high density lipoproteins impairs cholesterol efflux from mouse J774 macrophages: role of scavenger receptors, classes A and B - Suc I, Brunet S, Mitchell GA, Rivard G-É, Levy E. Oxidative tyrosylation of high density lipoproteins impairs cholesterol efflux from mouse J774 macrophages: role of scavenger receptors, classes A and B. J Cell Sci 2003; 116(Pt 1): 89-99.

The Quebec Child and Adolescent Health and Social Survey: design and methods of a cardiovascular risk factor survey for youth - Paradis G, Lambert MA, O'Loughlin JL, Lavallée C, Aubin J, Berthiaume P, Ledoux M, Delvin EE, Levy E, Hanley JA. The Quebec Child and Adolescent Health and Social Survey: design and methods of a cardiovascular risk factor survey for youth. Can J Cardiol 2003; 19(5): 523-531.

Distribution of fasting plasma insulin, free fatty acids, and glucose concentrations and of homeostasis model assessment of insulin resistance in a representative sample of Quebec children and adolescents - Allard P2, Delvin EE, Paradis G, Hanley JA, O'Loughlin JL, Lavallée C, Levy E, Lambert MA. Distribution of fasting plasma insulin, free fatty acids, and glucose concentrations and of homeostasis model assessment of insulin resistance in a representative sample of Quebec children and adolescents. Clin Chem 2003; 49(4): 644-649.

Apo A-IV: biosynthesis, regulation and physiologic functions - Stan S, Delvin EE, Lambert MA, Seidman EG, Levy E. Apo A-IV: biosynthesis, regulation and physiologic functions. Biochim Biophys Acta - Mol Cell Biol L 2003; 1631(2): 177-187.

Dyslipidemia in pediatric nephrotic syndrome: causes revisited - Delvin EE, Mérouani A, Levy E. Dyslipidemia in pediatric nephrotic syndrome: causes revisited. Clin Biochem 2003; 36(2): 95-101.

Effects of bile acids on biliary epithelial cells: proliferation, cytotoxicity, and cytokine secretion - Lamireau T, Zoltowska M, Levy E, Yousef IM, Rosenbaum J, Tuchweber B, Desmoulière A. Effects of bile acids on biliary epithelial cells: proliferation, cytotoxicity, and cytokine secretion. Life Sci 2003; 72(12): 1401-1411.

Mutations in a Sar1 GTPase of COPII vesicles are associated with lipid absorption disorders - Jones B, Jones EL, Bonney SA, Patel HN, Mensenkamp AR, Eichenbaum-Voline S, Rudling M, Myrdal U, Annesi G, Naik S, Meadows N, Quattrone A, Islam S, Naoumova RP, Angelin B, Infante R, Levy E, Roy CC, Freemont PS, Scott J, Shoulders C. Mutations in a Sar1 GTPase of COPII vesicles are associated with lipid absorption disorders. Nat Genet 2003; 23(1): 29-31.

Butyrate impairs lipid transport by inhibiting microsomal triglyceride transfer protein in Caco-2 cells - Marcil V, Delvin EE, Garofalo C, Levy E. Butyrate impairs lipid transport by inhibiting microsomal triglyceride transfer protein in Caco-2 cells. J Nutr 2003; 133(7): 2180-2183.

Cellular aspects of intestinal lipoprotein assembly in Psammomys Obesus: A model of insulin resistance and type 2 diabetes - Zoltowska M, Ziv E, Delvin EE, Kalman R, Sinnett D, Garofalo C, Seidman EG, Levy E. Cellular aspects of intestinal lipoprotein assembly in Psammomys Obesus: A model of insulin resistance and type 2 diabetes. Diabetes 2003; 52(10): 2539-2545.

Localization of microsomal triglyceride transfer protein in the Golgi: possible role in the assembly of chylomicrons - Levy E, Stan S, Delvin EE, Ménard D, Shoulders C, Garofalo C, Slight I, Seidman EG, Mayer G, Bendayan M. Localization of microsomal triglyceride transfer protein in the Golgi: possible role in the assembly of chylomicrons. J Biol Chem 2002; 277(19): 16470-16477.

The antioxidant BHT normalizes some oxidative effects of iron + ascorbate on lipid metabolism in Caco-2 cells - Courtois F, Delvin EE, Ledoux M, Seidman EG, Lavoie JC, Levy E. The antioxidant BHT normalizes some oxidative effects of iron + ascorbate on lipid metabolism in Caco-2 cells. J Nutr 2002; 132(6): 1289-1292.

Facteurs de risque de maladies cardiovasculaires - Paradis G, Lambert MA, O'Loughlin JL, Levy E, Delvin EE. Facteurs de risque de maladies cardiovasculaires. Dans: Institut de la statistique du Québec. Enquête sociale et de santé auprès des enfants et adolescents québécois. 1999. Québec. Les Publications du Québec, 2002; 345-370.

Photooxidation of parenteral multivitamins induces hepatic steatosis in a neonatal guinea pig model of intravenous nutrition - Chessex P, Lavoie JC, Rouleau T, Brochu P, St-Louis P, Levy E, Alvarez F. Photooxidation of parenteral multivitamins induces hepatic steatosis in a neonatal guinea pig model of intravenous nutrition. Pediatr Res 2002; 52(6): 958-963.

Modulation of lipid synthesis, apolipoprotein biogenesis and lipoprotein assembly by butyrate - Marcil V, Delvin EE, Seidman EG, Poitras L, Zoltowska M, Garofalo C, Levy E. Modulation of lipid synthesis, apolipoprotein biogenesis and lipoprotein assembly by butyrate. Am J Physiol Gastrointest Liver Physiol 2002; 283(2): G340-G346.

Nutritional modulation of gut inflammation - Seidman EG, Bernotti S, Levy E. Nutritional modulation of gut inflammation. Dans: Labadarios D, Pichard C (eds). Clinical Nutrition: Early Intervention. Basel (Suisse). Karger AG, 2002; 41-61.

Lipopolysaccharide modulation of normal enterocyte turnover by toll-like receptors is mediated by endogenously produced tumour necrosis factor alpha - Ruemmele F, Beaulieu J-F, Dionne S, Levy E, Seidman EG, Cerf-Bensussan N, Lentze MJ. Lipopolysaccharide modulation of normal enterocyte turnover by toll-like receptors is mediated by endogenously produced tumour necrosis factor alpha. Gut 2002; 51(6): 842-848.

The polymorphism at codon 54 of the fabp2 gene increases fat absorption in human intestinal explants - Levy E, Ménard D, Delvin EE, Stan S, Mitchell GA, Lambert MA, Ziv E, Feoli-Fonseca J-C, Seidman EG. The polymorphism at codon 54 of the fabp2 gene increases fat absorption in human intestinal explants. J Biol Chem 2001; 276(43): 39679-39684.

Immunolocalization, ontogeny and regulation of microsomal triglyceride transfer protein in human fetal intestine - Levy E, Stan S, Garofalo C, Delvin EE, Seidman EG, Ménard D. Immunolocalization, ontogeny and regulation of microsomal triglyceride transfer protein in human fetal intestine. Am J Physiol Gastrointest Liver Physiol 2001; 280(4): G563-G571.

Effect of human recombinant leptin on lipid handling by fully differentiated Caco-2 cells - Stan S, Levy E, Bendayan M, Zoltowska M, Lambert MA, Michaud JL, Asselin C, Delvin EE. Effect of human recombinant leptin on lipid handling by fully differentiated Caco-2 cells. FEBS Lett 2001; 508(1): 80-84.

Geographic variations of childhood cancers, notably brain tumour in Quebec (Canada) - Emard JF, Levy E, Thouez JP, Laroche P, Fathie K, Ghadirian P. Geographic variations of childhood cancers, notably brain tumour in Quebec (Canada). J Neurol Orthop Med Surg 2001; 21: 5-13.

Development of noninvasive and quantitative methodologies for the assessment of chronic ulcers and scars in humans - Timar-Banu O, Beauregard H, Tousignant J, Lassonde M, Harris P, Viau G, Vachon L, Levy E, Abribat T. Development of noninvasive and quantitative methodologies for the assessment of chronic ulcers and scars in humans. Wound Repair Regen 2001; 9(2): 123-132.

Modulation of intestinal and liver fatty acid-binding proteins in Caco-2 cells by lipids, hormones and cytokines - Dubé N, Delvin EE, Yotov WV, Garofalo C, Bendayan M, Veerkamp JH, Levy E. Modulation of intestinal and liver fatty acid-binding proteins in Caco-2 cells by lipids, hormones and cytokines. J Cell Biochem 2001; 81(4): 613-620.

The adipose tissue phenotype of hormone-sensitive lipase deficiency in mice - Wang SP, Laurin N, Himms-Hagen J, Rudnicki M, Levy E, Robert M-F, Pan L, Oligny LL, Mitchell GA. The adipose tissue phenotype of hormone-sensitive lipase deficiency in mice. Obes Res 2001; 9(2): 119-128.

Determinants of lipid level variability in French Canadian children with familial hypercholesterolemia - Lambert MA, Assouline L, Feoli-Fonseca J-C, Brun N, Delvin EE, Levy E. Determinants of lipid level variability in French Canadian children with familial hypercholesterolemia. Arterioscler Thromb Vasc Biol 2001; 21(6): 979-984.

Circulating lipoproteins and hepatic sterol metabolism in Psammomys obesus prone to obesity, hyperglycemia and hyperinsulinemia - Zoltowska M, Ziv E, Delvin EE, Stan S, Bar-On H, Kalman R, Levy E. Circulating lipoproteins and hepatic sterol metabolism in Psammomys obesus prone to obesity, hyperglycemia and hyperinsulinemia. Atherosclerosis 2001; 157(1): 85-96.

Sim 1 haploinsufficiency causes hyperphagia, obesity and reduction of the paraventricular nucleus of the hypothalamus - Michaud JL, Boucher F, Melnyk A, Gauthier F, Goshu E, Levy E, Mitchell GA, Himms-Hagen J, Fan CM. Sim 1 haploinsufficiency causes hyperphagia, obesity and reduction of the paraventricular nucleus of the hypothalamus. Hum Mol Genet 2001; 10(14): 1465-1473.

Developmental aspects of lipid and lipoprotein synthesis and secretion in human gut - Levy E, Ménard D. Developmental aspects of lipid and lipoprotein synthesis and secretion in human gut. Microsc Res Tech 2000; 49: 363-373.

Use of immunoelectron microscopy and intestinal models to explore the elaboration of apolipoproteins required for intraenterocyte lipid transport - Levy E, Bendayan M. Use of immunoelectron microscopy and intestinal models to explore the elaboration of apolipoproteins required for intraenterocyte lipid transport. Microsc Res Tech 2000; 49: 374-382.

Human crypt intestinal epithelial cells are capable of lipid production, apolipoprotein synthesis and lipoprotein assembly - Levy E, Beaulieu J-F, Delvin EE, Seidman EG, Yotov WV, Basque JR, Ménard D. Human crypt intestinal epithelial cells are capable of lipid production, apolipoprotein synthesis and lipoprotein assembly. J Lipid Res 2000; 41: 12-22.

Altered lipid profile, lipoprotein composition and oxidant/antioxidant status in pediatric Crohn's disease - Levy E, Rizwan Y, Thibault L, Lepage G, Brunet S, Bouthillier L, Seidman EG. Altered lipid profile, lipoprotein composition and oxidant/antioxidant status in pediatric Crohn's disease. Am J Clin Nutr 2000; 71(3): 807-815.

Digestion and absorption of carbohydrates, fat and proteins - Levy E. Digestion and absorption of carbohydrates, fat and proteins. Dans: Ratnaike RN (ed). Small Bowel Disorder. Londres. Kluwer Academic and Lippincott Raven Publishers, 2000; 162-189.

Modulation of endoplasmic reticulum-bound cholesteril regulatory enzymes by iron/ascorbate-mediated lipid peroxidation - Brunet S, Thibault L, Lepage G, Seidman EG, Dubé N, Levy E. Modulation of endoplasmic reticulum-bound cholesteril regulatory enzymes by iron/ascorbate-mediated lipid peroxidation. Free Radic Biol Med 2000; 28(1): 46-54.

Metabolic syndrome X - Timar O, Sestier F, Levy E. Metabolic syndrome X. Can J Cardiol 2000; 16(6): 779-789.

Nutrition as primary therapy in pediatric Crohn's disease: fact or fantasy? - Ruemmele F, Roy CC, Levy E, Seidman EG. Nutrition as primary therapy in pediatric Crohn's disease: fact or fantasy?. J Pediatr 2000; 136(3): 285-291.

Roles of molecular chaperones in pancreatic secretion and their involvement in intestinal absorption - Bruneau N, Lombardo D, Levy E, Bendayan M. Roles of molecular chaperones in pancreatic secretion and their involvement in intestinal absorption. Microsc Res Tech 2000; 49: 329-345.

Iron/ascorbate-mediated lipid peroxidation alters the efficiency of caco-2 cells to assemble and secrete lipoproteins - Courtois F, Suc I, Garofalo C, Ledoux M, Seidman EG, Levy E. Iron/ascorbate-mediated lipid peroxidation alters the efficiency of caco-2 cells to assemble and secrete lipoproteins. Am J Physiol Gastrointest Liver Physiol 2000; 279(1): G12-19.

Importance des acides gras essentiels - Levy E. Importance des acides gras essentiels. Le Point INN 1999; 23: 47-55.

Caco-2 cells and human fetal colon: a comparative analysis of their lipid transport - Levy E, Yotov WV, Seidman EG, Garofalo C, Delvin EE, Ménard D. Caco-2 cells and human fetal colon: a comparative analysis of their lipid transport. Biochim Biophys Acta 1999; 1439: 353-362.

Prolonged post-prandial increment in obese subjects with intra-abdominal visceral fat accumulation - Levy E, Zoltowska M. Prolonged post-prandial increment in obese subjects with intra-abdominal visceral fat accumulation. Eur J Clin Invest 1999; 29: 271-273.

Dietary iron overload and induced lipid peroxidation are associated with impaired plasma lipid transport and hepatic sterol metabolism - Brunet S, Thibault L, Delvin EE, Yotov WV, Bendayan M, Levy E. Dietary iron overload and induced lipid peroxidation are associated with impaired plasma lipid transport and hepatic sterol metabolism. Hepatology 1999; 29: 1809-1817.

Dexamethasone inhibits IFNg - induced MHC class II expression of intestinal epithelial cells independently of the TGF-b1 regulatory pathway - Ruemmele F, Dionne S, Levy E, Seidman EG. Dexamethasone inhibits IFNg - induced MHC class II expression of intestinal epithelial cells independently of the TGF-b1 regulatory pathway. Aliment Pharmacol Therap 1999; 13: 595-601.

TNF alpha-induced IEC-6 cell apoptosis requires activation of ICE caspases whereas complete inhibition of the caspace-cascade leads to necrotic cell death - Ruemmele F, Dionne S, Levy E, Seidman EG. TNF alpha-induced IEC-6 cell apoptosis requires activation of ICE caspases whereas complete inhibition of the caspace-cascade leads to necrotic cell death. Biochem Biophys Res Commun 1999; 260: 159-166.

Modulation of apo A-IV transcript levels and synthesis by n-3, n-6 and n-9 fatty acids in caco-2 cells - Stan S, Delvin EE, Seidman EG, Rouleau T, Steinmetz A, Bendayan M, Yotov WV, Levy E. Modulation of apo A-IV transcript levels and synthesis by n-3, n-6 and n-9 fatty acids in caco-2 cells. J Cell Biochem 1999; 75: 73-81.

Molecular mechanisms regulating intestinal epithelial cell turnover by nutrients - Ruemmele F, Ruemmele C, Levy E, Seidman EG. Molecular mechanisms regulating intestinal epithelial cell turnover by nutrients. Gastroenterol Clin Biol 1999; 23: 47-55.

Amplifications of DNA primase 1 (PRIM1) in human osteosarcoma - Yotov WV, Hamel H, Rivard G-É, Champagne M, Russo P, Leclerc JM, Bernstein M, Levy E. Amplifications of DNA primase 1 (PRIM1) in human osteosarcoma. Gene Chromosomes Cancer 1999; 26: 62-69.

Bile duct cells: A novel in vitro model for the study of lipid metabolism. Implications for the autonomous role of biliary epithelium in bile acid production - Zoltowska M, Delvin EE, Paradis K, Seidman EG, Levy E. Bile duct cells: A novel in vitro model for the study of lipid metabolism. Implications for the autonomous role of biliary epithelium in bile acid production. Am J Physiol 1999; 276: G407-414.

Susceptibility to FAS-induced apoptosis in human nontumoral enterocytes: role of costimulatory factors - Ruemmele F, Russo P, Beaulieu J-F, Dionne S, Levy E, Lentze MJ, Seidman EG. Susceptibility to FAS-induced apoptosis in human nontumoral enterocytes: role of costimulatory factors. J Cell Physiol 1999; 181: 45-54.

Butyrate mediates Caco-2 cell apoptosis via up-regulation of pro-apoptotic bak and inducing caspase-3 mediated cleavage of poly-(ADP-ribose) polymerase (PARP) - Ruemmele F, Dionne S, Qureshi IA, Sarma DSR, Levy E, Seidman EG. Butyrate mediates Caco-2 cell apoptosis via up-regulation of pro-apoptotic bak and inducing caspase-3 mediated cleavage of poly-(ADP-ribose) polymerase (PARP). Cell Death Differ 1999; 6: 729-735.

Le cholestérol de cette tartelette, docteur, est-il bon ou mauvais? - Rasio E, Levy E. Le cholestérol de cette tartelette, docteur, est-il bon ou mauvais?. 1998; 11: 5.

Familial lipoprotein lipase deficiency in infancy: clinical, biochemical and molecular study - Feoli-Fonseca J-C, Levy E, Godard M, Lambert MA. Familial lipoprotein lipase deficiency in infancy: clinical, biochemical and molecular study. J Pediatr 1998; 133: 417-423.

Apolipoproteins in human fetal colon: immunolocalization, biogenesis and hormonal regulation - Basque JR, Levy E, Beaulieu J-F, Ménard D. Apolipoproteins in human fetal colon: immunolocalization, biogenesis and hormonal regulation. J Cell Biochem 1998; 70: 354-365.

Tyrosine kinase and MAPK inhibition of TNFa and EGF stimulated IEC-6 cell growth - Dionne S, D'Agata ID, Ruemmele F, Levy E, St-Louis J, Srivastava AK, Lévesque D, Seidman EG. Tyrosine kinase and MAPK inhibition of TNFa and EGF stimulated IEC-6 cell growth. Biochem Biophys Res Commun 1998; 242: 146-150.

Effects of Interferon g on growth, apoptosis, and MHC class II expression of immature rat intestinal crypt (IEC-6) - Ruemmele F, Gurbindo C, Mansour AM, Marchand R, Levy E, Seidman EG. Effects of Interferon g on growth, apoptosis, and MHC class II expression of immature rat intestinal crypt (IEC-6). J Cell Physiol 1998; 176: 120-126.

The role of dietary cholin in the beneficial effect of lecithin on bile secretion - LeBlanc MJ, Gavino V, Perea A, Yousef IM, Levy E, Tuchweber B. The role of dietary cholin in the beneficial effect of lecithin on bile secretion. Biochim Biophys Acta 1998; 1393: 223-234.

Uptake and metabolism of a structured triglyceride by CACO-2 cells : Reversal of essential fatty acid deficiency - Spalinger J, Seidman EG, Lepage G, Ménard D, Gavino V, Levy E. Uptake and metabolism of a structured triglyceride by CACO-2 cells : Reversal of essential fatty acid deficiency. Am J Physiol 1998; 275: G652-659.

Endogenous lipase activity in CACO-2 cells - Spalinger J, Seidman EG, Ménard D, Levy E. Endogenous lipase activity in CACO-2 cells. Biochim Biophys Acta 1998; 1393: 119-127.

Régulation de l'expression génétique du récepteur des LDL par les facteurs transcriptionnels - Assouline L, Lambert MA, Delvin EE, Levy E. Régulation de l'expression génétique du récepteur des LDL par les facteurs transcriptionnels. 1998; 14: 729-735.

The effects of cholesterol uptake from high-density lipoprotein on biliary sterol secretion in essential fatty acid deficiency - Wanon J, Guertin F, Brunet S, Delvin EE, Gavino V, Bouthillier D, Lairon D, Yotov WV, Levy E. The effects of cholesterol uptake from high-density lipoprotein on biliary sterol secretion in essential fatty acid deficiency. Hepatology 1998; 27: 779-786.

Association of an exon 3 mutation (Trp66ÆGly) of the LDL receptor with variable expression of familial hypercholesterolemia in a French Canadian family - Levy E, Minnich A, Cacan S, Thibault L, Giroux M, Davignon J, Lambert MA. Association of an exon 3 mutation (Trp66ÆGly) of the LDL receptor with variable expression of familial hypercholesterolemia in a French Canadian family. Biochem Mol Med 1997; 60: 59-69.

Selective effects of hydrocortisone on intestinal lipoprotein and apolipoprotein synthesis in the human fetus - Levy E, Loirdighi N, Delvin EE, Ménard D. Selective effects of hydrocortisone on intestinal lipoprotein and apolipoprotein synthesis in the human fetus. J Cell Biochem 1997; 66: 65-76.

Lipid apolipoprotein and lipoprotein synthesis and secretion during cellular differentiation in Caco-2 cells - Mehran M, Levy E, Gurbindo C, Bendayan M, Seidman EG. Lipid apolipoprotein and lipoprotein synthesis and secretion during cellular differentiation in Caco-2 cells. In Vitro Cell Dev Biol 1997; 33: 118-128.

Iron-salicylate complex induces peroxidation, alters hepatic lipid profile and affects plasma lipoprotein composition - Brunet S, Guertin F, Thibault L, Gavigno V, Delvin EE, Levy E. Iron-salicylate complex induces peroxidation, alters hepatic lipid profile and affects plasma lipoprotein composition. Atherosclerosis 1997; 129: 159-168.

Metabolism of 4,7,10,13,16,19 docosahexaenoic acid in isolated perfused adult and newborn pig eyes - Abran D, Chemtob S, Levy E, Gavino GR, Gavino V. Metabolism of 4,7,10,13,16,19 docosahexaenoic acid in isolated perfused adult and newborn pig eyes. Biol Neonate 1997; 72: 32-41.

Ontogeny and location of HMG-CoA reductase, ACAT and monoacylglycerol acyltransferase (MCAT) in the human small intestine - Loirdighi N, Ménard D, Delvin EE, Levy E. Ontogeny and location of HMG-CoA reductase, ACAT and monoacylglycerol acyltransferase (MCAT) in the human small intestine. Am J Physiol 1997; 273: G62-G67.

Oxidative tyrosylation of high density lipoprotein impairs biliary sterol secretion in rats - Guertin F, Brunet S, Lairon D, Levy E. Oxidative tyrosylation of high density lipoprotein impairs biliary sterol secretion in rats. Atherosclerosis 1997; 131: 35-41.

Chronic dietary fat intake, post-prandial lipemia and atheroma in the NZ rabbit - Juhel C, Pasquier B, Armand M, Senft M, Levy E, Lairon D. Chronic dietary fat intake, post-prandial lipemia and atheroma in the NZ rabbit. Brit J Nutr 1997; 78: 301-311.

Identification of two novel LDL receptor gene defects in the French Canadian pediatric population: Mutational analysis and biochemical studies - Assouline L, Leitersdorf E, Lambert MA, Reschef A, Feoli-Fonseca J-C, Levy E. Identification of two novel LDL receptor gene defects in the French Canadian pediatric population: Mutational analysis and biochemical studies. Hum Mutat 1997; 9: 555-562.

The genetic basis of primary disorders of intestinal fat transport - Levy E. The genetic basis of primary disorders of intestinal fat transport. Clin Invest Med 1996; 19: 317-324.

Lipid processing and lipoprotein synthesis by the developping human fetal colon - Levy E, Loirdighi N, Thibault L, Nguyen TD, Labuda D, Delvin EE, Ménard D. Lipid processing and lipoprotein synthesis by the developping human fetal colon. Am J Physiol 1996; 270: G813-G820.

Insulin modulation of newly synthesized apolipoproteins B-100 and B-48 in the human fetal intestine: Gene expression and mRNA editing are not involved - Levy E, Sinnett D, Thibault L, Nguyen TD, Delvin EE, Ménard D. Insulin modulation of newly synthesized apolipoproteins B-100 and B-48 in the human fetal intestine: Gene expression and mRNA editing are not involved. FEBS Lett 1996; 393: 253-258.

Impact of essential fatty acid deficiency on hepatic sterol metabolism in rats - Levy E, Garofalo C, Rouleau T, Gavino V, Bendayan M. Impact of essential fatty acid deficiency on hepatic sterol metabolism in rats. Hepatology 1996; 23: 848-857.

Caco-2 cell disaccharidase activities are unaffected by gestational hormones - Solomon R, Levy E, Szilagyi A, Seidman EG. Caco-2 cell disaccharidase activities are unaffected by gestational hormones. Can J Physiol Pharmacol 1996; 74(10): 1126-1131.

Effect of calcitriol on the levels of RNA encoding for calcitriol receptors, calcium binding-protein, and calcidiol-24-hydroxylase in human fetal intestine - Delvin EE, Lopez V, Levy E, Ménard D. Effect of calcitriol on the levels of RNA encoding for calcitriol receptors, calcium binding-protein, and calcidiol-24-hydroxylase in human fetal intestine. Biochem Biophys Res Commun 1996; 224: 544-548.

Developmental expression of calcitriol receptors, calcium binding protein 9kDa and calcidiol 24-hydroxylase in human intestine. - Delvin EE, Lopez V, Levy E, Ménard D. Developmental expression of calcitriol receptors, calcium binding protein 9kDa and calcidiol 24-hydroxylase in human intestine.. Pediatr Res 1996; 40: 1-6.

Effets du calcitriol sur le développement de l'intestin foetal humain - Delvin EE, Ménard D, Levy E. Effets du calcitriol sur le développement de l'intestin foetal humain. Arch Pediatr 1996; 3(suppl 1): 119s-120s.

Treatment of familial hypercholesterolemia in children and adolescents: Effect of lovastatin - Lambert MA, Lupien P-J, Gagné C, Levy E, Blaichman S, Langlois S, Hayden M, Rose V, Clarke JTR, Wolfe B, Clarson C, Parsons H, Stephure DK, Potvin D, Lambert J, and the Canadian Lovastatin in Children Study Group. Treatment of familial hypercholesterolemia in children and adolescents: Effect of lovastatin. Pediatr Res 1996; 97: 619-628.

Expression of calcium binding protein 9K, Calcitriol specific receptors and 25-hydroxycholecalciferol-24-hydroxylase along the human fetal intestinal tract - Delvin EE, Lopez V, Levy E, Ménard D. Expression of calcium binding protein 9K, Calcitriol specific receptors and 25-hydroxycholecalciferol-24-hydroxylase along the human fetal intestinal tract. Pediatr Res 1996; 40: 664-670.

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