Chercheur

    Natalie Patey , M.D. , Ph.D.

    natalie.patey.hsj@ssss.gouv.qc.ca
    Natalie Patey
    Axe de recherche
    Maladies virales, immunitaires et cancers
    Thème de recherche
    Maladies hématologiques sévères
    Adresse
    CHUSJ

    Téléphone
    514 345-4931 #2678

    Fax
    514 345-4819

    Titres

    • Professeur adjoint, Département de pathologie et biologie cellulaire, Université de Montréal

    Formation

    •  2003, Diplôme Inter Universitaire de Pathologie Rénale,Université Paris VII, Paris, France
    •  2002, Diplôme Inter Universitaire de Fœtopathologie, Université Paris VII, Paris, France
    •  1998, Doctorat en Sciences, Université Paris V, Faculté de Médecine Necker-Enfants Malades, Paris, France
    •  1993, Doctorat en Médecine, Université Paris V, Faculté de Médecine Necker-Enfants Malades, Paris, France
    •  1993, Diplôme d'Études Spécialisées d'Anatomie et Cytologie Pathologiques, Université Paris V, Faculté de Médecine Necker-Enfants Malades, Paris, France

    Intérêts de recherche

    • Oncologie Pédiatrique : Caractérisation moléculaire
    • Gastroentérologie Pédiatrique : Optimisation du diagnostic positif de la maladie cœliaque, de la maladie de Hirschsprung et des colites au cours de la cholangite sclérosante

    Expertises de recherche

    • Morphologie
    • Immunohistochimie
    • FISH

    Présentations

    • M. Morris¹, N. Patey², D. Dal Soglio², A. Ouimet¹, A. Aspirot. A study of Calretinin in Hirschsprung Pathology Particularly in Total Colonic Aganglianosis. 2012 meeting of the Canadian Association of Paediatric Surgeons (CAPS)
    • Lapeyraque AL, V Frémeaux-Bacchi, F Ledeist, Patey N. C3 deposition glomerulopathy associated with C3 nephritic factor (C3Nef), heterozygous mutation in factor I gene and anti-factor H auto-antibodies. Congrès Européen de Pathologie Prague Septembre 2012
    • Silvas E, Marchand V, Prévost J, Cutz E, Patey N. Familial hemaphagocytic lymphohistiocytosis type 5 in a patient with Micro Villous Inclusion Disease. ASCP Boston 2012 31 oct-3 nov.
    • N Patey O Boyer, C Noto, O Goulet. Etude de la fonction et de l’histologie rénale en transplantation digestive. 11 ème colloque de la Société québéquoise de transplantation. Québec (QC) 5-7 octobre 2012.
    • Beland K, Dore-Nguyen M, Gagne MJ, Patey N, Brassard J, Alvarez F, Halac U. Impact of immunosuppression and hepatitis E virus infection on viriome of children with orthotopic liver transplantation. AASLD 9-13 nov 2012, Boston , MA

Publications

Diagnostic utility of molecular and cytogenetic analysis in lipoblastoma: a study of two cases and review of the literature - Choi J, Bouron-Dal Soglio D, Fortier A, Fetni R, Mathonnet G, Cournoyer S, Lallier M, Isler M, Beaulieu Bergeron M, Patey N. Diagnostic utility of molecular and cytogenetic analysis in lipoblastoma: a study of two cases and review of the literature. Histopathology 2014; 64(5): 731-740.

Torque Teno virus in children who underwent orthotopic liver transplantation: new insights about a common pathogen - Béland K, Dore-Nguyen M, Gagné MJ, Patey N, Brassard J, Alvarez F, Halac U. Torque Teno virus in children who underwent orthotopic liver transplantation: new insights about a common pathogen. J Infect Dis 2014; 209(2): 247-254.

Torque Teno virus load as a biomarker of immunosuppression? New hopes and insights - Béland K, Dore-Nguyen M, Gagné MJ, Patey N, Brassard J, Alvarez F, Halac U. Torque Teno virus load as a biomarker of immunosuppression? New hopes and insights. J Infect Dis 2014; (sous presse).

TTV viral load as a biomarker of immunosuppression? New hopes and insights - Béland K, Dore-Nguyen M, Gagné MJ, Patey N, Brassard J, Alvarez F, Halac U. TTV viral load as a biomarker of immunosuppression? New hopes and insights. J Infect Dis 2014; (sous presse).

Inflammatory bowel disease and T cell lymphopenia in G6PC3 deficiency - Bégin P, Patey N, Mueller P, Rasquin A, Sirard A, Klein C, Haddad E, Drouin E, Le Deist F. Inflammatory bowel disease and T cell lymphopenia in G6PC3 deficiency. J Clin Immunol 2013; 33(3): 520-525.

A study of calretinin in Hirschsprung pathology, particularly in total colonic aganglionosis - Morris M, Bouron-Dal Soglio D, Ouimet A, Aspirot A, Patey N. A study of calretinin in Hirschsprung pathology, particularly in total colonic aganglionosis. J Pediatr Surg 2013; 48(5): 1037-1043.

Ovotestis avec dysgénésie tubulaire - Patey N, Brochu P. Ovotestis avec dysgénésie tubulaire. Ann Pathol 2013; 33: 150-151.

Prenatal diagnosis of femoral-facial syndrome: report of two cases - Silvas E, Rypens F, Jovanovic M, Delezoide AL, Patey N. Prenatal diagnosis of femoral-facial syndrome: report of two cases. Birth Defects Res Part A Clin Mol Teratol 2013; 97(12): 770-773.

Renal function and histology in children after small bowel transplantation - Boyer O, Noto C, Patey N, Gubler MC, Dechaux M, Goulet O, Niaudet P, Lacaille F. Renal function and histology in children after small bowel transplantation. Pediatr Transplant 2013; 17(1): 65-72.

Exome sequencing identifies mutations in the gene TTC7A in French-Canadian cases with hereditary multiple intestinal atresia - Samuels ME, Majewski J, Aljazaeri A, Fernandez I, Casals F, Patey N, Decaluwé H, Gosselin I, Haddad E, Hodgkinson A, Idaghdour Y, Marchand V, Michaud JL, Rodrigue MA, Desjardins S, Dubois S, Le Deist F, Awadalla P, Raymond V, Maranda B. Exome sequencing identifies mutations in the gene TTC7A in French-Canadian cases with hereditary multiple intestinal atresia. J Med Genet 2013; 50(5): 324-329.

Antiperlecan antibodies are novel accelerators of immune-mediated vascular injury - Cardinal H, Dieudé M, Brassard N, Qi S, Patey N, Soulez M, Beillevaire D, Echeverry F, Daniel C, Durocher Y, Madore F, Hébert MJ. Antiperlecan antibodies are novel accelerators of immune-mediated vascular injury. Am J Transplant 2013; 13(4): 861-874.

Nerve growth factor content is increased in the rectal mucosa of children with diarrhea-predominant irritable bowel syndrome - Willot S, Gauthier C, Patey N, Faure C. Nerve growth factor content is increased in the rectal mucosa of children with diarrhea-predominant irritable bowel syndrome. Neurogastroenterol Motil 2012; 24(8): 734-9, e347.

A t(17;22)(q21;q12) with partial ETV4 deletion in a soft tissue Ewing sarcoma - Rougemont A-L, Bouron-Dal Soglio D, Patey N, Fetni R, Fan L, Barrette S, Fournet JC. A t(17;22)(q21;q12) with partial ETV4 deletion in a soft tissue Ewing sarcoma. Cancer Genet 2012; 205(1-2): 55-60.

Perianal rhabdomyosarcoma presenting 21 months after hamartoma excision - Piché N, Patey N, Bouron-Dal Soglio D, Samson Y, Bouchard S. Perianal rhabdomyosarcoma presenting 21 months after hamartoma excision. Pediatr Surg Int 2012; 28(7): 731-735.

Cirrhosis due to chronic hepatitis E infection in a child post-bone marrow transplant - Halac U, Béland K, Lapierre P, Patey N, Ward P, Brassard J, Houde A, Alvarez F. Cirrhosis due to chronic hepatitis E infection in a child post-bone marrow transplant. J Pediatr 2012; 160(5): 871-874.e1.

Therapeutic efficacy of cord blood-derived mesenchymal stromal cells for the prevention of acute GVHD in a xenogenic mouse model - Grégoire-Gauthier J, Selleri S, Fontaine F, Dieng Mame M, Patey N, Despars G, Beauséjour C, Haddad E. Therapeutic efficacy of cord blood-derived mesenchymal stromal cells for the prevention of acute GVHD in a xenogenic mouse model. Stem Cells Dev 2012; 21(10): 1616-1626.

Use of immunoglobulins in the prevention of GvHD in a xenogeneic NOD/SCID/?c- mouse model - Grégoire-Gauthier J, Durrieu L, Duval A, Fontaine F, Dieng Mame M, Bourgey M, Patey N, Louis I, Haddad E. Use of immunoglobulins in the prevention of GvHD in a xenogeneic NOD/SCID/γc- mouse model. Bone Marrow Transplant 2012; 47(3): 439-450.

A stepwise breakdown of B-cell tolerance occurs within renal allografts during chronic rejection - Thaunat O, Graff-Dubois S, Fabien N, Duthey A, Attuil-Audenis V, Nicoletti A, Patey N, Morelon E. A stepwise breakdown of B-cell tolerance occurs within renal allografts during chronic rejection. Kidney Int 2012; 81(2): 207-219.

46, XY gonadal dysgenesis: new SRY point mutation in two siblings with paternal germ line mosaicism - Stoppa-Vaucher S, Ayabe T, Paquette J, Patey N, Francoeur D, Vuissoz JM, Deladoëy J, Samuels ME, Ogata K, Deal C. 46, XY gonadal dysgenesis: new SRY point mutation in two siblings with paternal germ line mosaicism. Clin Genet 2012; 82(6): 505-513.

Chronic hepatitis E infection in children with liver transplantation - Halac U, Béland K, Lapierre P, Patey N, Ward P, Brassard J, Houde A, Alvarez F. Chronic hepatitis E infection in children with liver transplantation. Gut 2012; 61(4): 597-603.

Serotonin signalling is altered in irritable bowel syndrome with diarrhea but not in functional dyspepsia in pediatric age patients - Faure C, Patey N, Gauthier C, Brooks EM, Mawe GM. Serotonin signalling is altered in irritable bowel syndrome with diarrhea but not in functional dyspepsia in pediatric age patients. Gastroenterology 2010; 139(1): 249-258.

[Juvenile xanthogranuloma of the nasal cavity] - Chami R, Aleynikova O, Abela A, Blais M, Oligny LL, Bouron-Dal Soglio D, Patey N. [Juvenile xanthogranuloma of the nasal cavity]. Ann Pathol 2010; 30(5): 374-377.

Chronic rejection triggers the development of an aggressive intragraft immune response through recapitulation of lymphoid organogenesis - Thaunat O, Patey N, Caligiuri G, Gautreau C, Mamani-Matsuda M, Mekki Y, Dieu-Nosjean MC, Eberl G, Ecochard R, Michel JB, Graff-Dubois S, Nicoletti A. Chronic rejection triggers the development of an aggressive intragraft immune response through recapitulation of lymphoid organogenesis. J Immunol 2010; 185(1): 717-728.

Tissue accumulation of lanthanum as compared to aluminum in rats with chronic renal failure--possible harmful effects after long-term exposure - Nikolov IG, Joki N, Vicca S, Patey N, Auchère D, Benchitrit J, Flinois JP, Ziol M, Beaune P, Drüeke TB, Lacour B. Tissue accumulation of lanthanum as compared to aluminum in rats with chronic renal failure--possible harmful effects after long-term exposure. Nephron Exp Nephrol 2010; 115(4) : e112-121.

Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors - Cros J, Cagnard N, Woollard K, Patey N, Zhang SY, Senechal B, Puel A, Biswas SK, Moshous D, Picard C, Jais JP, D'Cruz S, Casanova JL, Trouillet C, Geissmann F. Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors. Immunity 2010; 33(3): 375-386.

Reduced expression of FOXP3 and regulatory T-cell function in severe forms of early-onset autoimmune enteropathy - Moes N, Rieux-Laucat F, Begue B, Verdier J, Neven B, Patey N, Torgerson TT, Picard C, Stolzenberg MC, Ruemmele C, Rings EH, Casanova JL, Piloquet H, Biver A, Breton A, Ochs HD, Hermine O, Fischer A, Goulet O, Cerf-Bensussan N, Ruemmele F. Reduced expression of FOXP3 and regulatory T-cell function in severe forms of early-onset autoimmune enteropathy. Gastroenterology 2010; 139(3): 770-778.

Intragraft Th17 infiltrate promotes lymphoid neogenesis and hastens clinical chronic rejection - Deteix C, Attuil-Audenis V, Duthey A, Patey N, McGregor B, Dubois V, Caligiuri G, Graff-Dubois S, Morelon E, Thaunat O. Intragraft Th17 infiltrate promotes lymphoid neogenesis and hastens clinical chronic rejection. J Immunol 2010; 184(9): 5344-5351.

Glomerular collapse associated with subtotal renal infarction in kidney transplant recipients with multiple renal arteries - Canaud G, Bruneval P, Noël L, Correas JM, Audard V, Zafrani L, Rabant M, Timsit MO, Martinez F, Anglicheau D, Thervet E, Patey N, Legendre C, Zuber J. Glomerular collapse associated with subtotal renal infarction in kidney transplant recipients with multiple renal arteries. Am J Kidney Dis 2010; 55(3): 558-565.

Lupus nephritis associated with complete C1S deficiency efficiently treated with rituximab: A case report - Bienaime F, Quartier P, Dragon-Durey MA, Frémeaux-Bacchi V, Bader-Meunier B, Patey N, Salomonand R, Noël L. Lupus nephritis associated with complete C1S deficiency efficiently treated with rituximab: A case report. Arthritis Care Res (Hoboken) 2010; 62(9): 1346-1350.

Digestive histopathological presentation of IPEX syndrome - Patey N, Canioni D, Ganousse S, Rieux-Laucat F, Goulet O, Ruemmele F, Brousse N. Digestive histopathological presentation of IPEX syndrome. Mod Pathol 2009; 22(1): 95-102.

Coeliac disease and aplastic anaemia: a specific entity? - Salmeron G, Patey N, de Latour RP, Raffoux E, Gluckman E, Brousse N, Socie G, Robin M. Coeliac disease and aplastic anaemia: a specific entity?. Brit J Haematol 2009; 146(1): 122-124.

Thrombotic microangiopathy secondary to VEGF pathway inhibition by sunitinib - Bollée G, Patey N, Cazajous G, Robert C, Goujon JM, Fakhouri F, Bruneval P, Noël L, Knebelmann B. Thrombotic microangiopathy secondary to VEGF pathway inhibition by sunitinib. Nephrol Dial Transpl 2009; 24(2): 682-685.

Pauci-immune crescentic glomerulonephritis associated with ANCA of IgA class - Bollée G, Noël L, Suarez F, Royal V, Gilardin L, Patey N, El-Ghoul B, Lesavre P, Alyanakian MA, Fakhouri F. Pauci-immune crescentic glomerulonephritis associated with ANCA of IgA class. Am J Kidney Dis 2009; 53(6): 1063-1067.

Suture or hemostatic agent during laparoscopic partial nephrectomy? A randomized study using a hypertensive porcine model - Rouach Y, Delongchamps NB, Patey N, Fontaine E, Timsit MO, Thiounn N, Méjean A. Suture or hemostatic agent during laparoscopic partial nephrectomy? A randomized study using a hypertensive porcine model. Urology 2009; 73(1): 172-177.

FoxP3 positive T cells in graft biopsies from living donor kidney transplants after donor-specific transfusions - Eisenberger U, Seifried A, Patey N, Kappeler A, Noël L, Frey FJ, Körner M. FoxP3 positive T cells in graft biopsies from living donor kidney transplants after donor-specific transfusions. Transplantation 2009; 87(1): 138-142.

FOXP3-enriched infiltrates associated with better outcome in renal allografts with inflamed fibrosis - Zuber J, Brodin-Sartorius A, Lapidus N, Patey N, Tosolini M, Candon S, Rabant M, Snanoudj R, Panterne C, Thervet E, Legendre C, Chatenoud L. FOXP3-enriched infiltrates associated with better outcome in renal allografts with inflamed fibrosis. Nephrol Dial Transpl 2009; 24(12): 3847-3854.

[Leading article from the editorial board] - Scoazec JY, Sabourin JC, Adle-Biassette H, Bralet MP, Chenard-Neu MP, Cochand-Priollet B, Guettier C, Molinié V, Paraf F, Patey N, Vielh P. [Leading article from the editorial board]. Ann Pathol 2009; 29(1): 1-2.

[Lymphoid neogenesis and lymphangiogenesis: two newcomers in the pathophysiology of chronic rejection] - Attuil-Audenis V, Duthey A, Patey N, Gautreau C, McGregor B, Morelon E, Michel JB, Nicoletti A, Thaunat O. [Lymphoid neogenesis and lymphangiogenesis: two newcomers in the pathophysiology of chronic rejection]. Nephrol Ther 2009; 5(2): 91-96 .

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