Chercheur

    France Gauvin , M.D.

    france_gauvin@ssss.gouv.qc.ca
    France Gauvin
    Axe de recherche
    Santé métabolique et maladies complexes
    Thème de recherche
    Soins aigus et médecine transfusionnelle
    Adresse
    CHUSJ

    Téléphone
    514 345-4931 #6812

    Fax
    514 345-7731

    Titres

    • Professeur agrégé de clinique, Département de pédiatrie, Université de Montréal.
    • Clinicien-chercheur, Département de pédiatrie et Centre de recherche CHU Sainte-Justine.

    Formation

    • Maîtrise en sciences biomédicales, option épidémiologie, Université de Montréal, 2001.
    • MD, Université de Montréal, 1993.

    Intérêts de recherche

    Je suis pédiatre au CHU Sainte-Justine depuis 1999. Après dix ans de clinique aux soins intensifs, je travaille maintenant à la salle d’urgence et en soins palliatifs pédiatriques. Depuis mon arrivée au CHU Sainte-Justine, je reste très active au niveau de la recherche clinique. Je me spécialise dans les types de recherche suivants : validation de tests, étude épidémiologique (incidence, facteurs de risques), essai clinique et revue systématique.

    Je m'intéresse particulièrement aux transfusions sanguines, surtout les complications respiratoires qui y sont associées, ainsi qu’aux soins palliatifs et soins de fin de vie. D'autres intérêts importants pour moi sont le sepsis, la ventilation mécanique et l’insuffisance rénale.
    Collaboration : Réseau stratégique du Réseau en santé respiratoire du FRSQ.

    Prix et distinctions

    • Mention d'honneur du doyen, maîtrise en sciences biomédicales, option épidémiologie, Université de Montréal, 2002.
    • Prix B.G. Bourgeois, excellence du stage et de l'examen de chirurgie, Université de Montréal, 1993.
    • Prix Lange, classée 3e dans le programme MD, Université de Montréal, 1993.

Publications

Weaning children from mechanical ventilation with a computer-driven protocol: a pilot trial - Jouvet P, Payen V, Gauvin F, Emeriaud G, Lacroix J. Weaning children from mechanical ventilation with a computer-driven protocol: a pilot trial. Intensive Care Med 2013; 39(5): 919-925.

Modes of death in pediatrics: differences in the ethical approach in neonatal and pediatric patients - Fontana M, Farrell CA, Gauvin F, Lacroix J, Janvier A. Modes of death in pediatrics: differences in the ethical approach in neonatal and pediatric patients. J Pediatr 2013; 162(6): 1107-1111.

Transfusion-related acute lung injury in the Canadian paediatric population - Gauvin F, Robillard P, Hume HA, Grenier D, Whyte R, Webert KE, Ferguson D, Lau W, Froese N, Delage G. Transfusion-related acute lung injury in the Canadian paediatric population. Pediatr Child Health 2012; 17(5): 235-239.

Could organ dysfunctions and other morbidity measures be misleading - Karam O, Tucci M, Ducruet T, Hume HA, Lacroix J, Gauvin F. Could organ dysfunctions and other morbidity measures be misleading. Pediatr Crit Care Med 2012; 13: 495.

Mortality associated with restrictive threshold for red blood cell transfusion in pediatric patients with sepsis - Karam O, Tucci M, Ducruet T, Hume HA, Lacroix J, Gauvin F. Mortality associated with restrictive threshold for red blood cell transfusion in pediatric patients with sepsis. Pediatr Crit Care Med 2012; 13(4): 495: doi: 10.1097/PCC.0b013e31824fbefe.

Risk factors associated with increased length of mechanical ventilation in children - Payen V, Jouvet P, Lacroix J, Ducruet T, Gauvin F. Risk factors associated with increased length of mechanical ventilation in children. Pediatr Crit Care Med 2012; 13(2): 152-157.

Transfusion medicine - Tucci M, Lacroix J, Gauvin F, Toledano B, Robitaille N. Transfusion medicine. Dans: Wheeler DS, Wong HR, Shaley TP(eds). Pediatric Critical Care Medicine: Basic science and clinical evidence, 2nd edition. London. Springer-Verlag, 2012; (sous presse).

Red blood cell transfusion thresholds in pediatric patients with sepsis - Karam O, Tucci M, Ducruet T, Hume HA, Lacroix J, Gauvin F, for the Canadian Critical Care Trials Group, and the PALISI Network. Red blood cell transfusion thresholds in pediatric patients with sepsis. Pediatr Crit Care Med 2011; 12(5): 512-518.

Transient creatine phosphokinase elevations in children: a single-center experience - Perreault S, Birca A, Piper D, Nadeau A, Gauvin F, Vanasse M. Transient creatine phosphokinase elevations in children: a single-center experience. J Pediatr 2011; 159(4): 682-685.

Acute kidney injury is an independent risk factor for pediatric intensive care unit mortality, longer length of stay and prolonged mechanical ventilation in critically ill children: a two-center retrospective cohort study - Alkandari O, Eddington KA, Hyder A, Gauvin F, Ducruet T, Gottesman R, Phan V, Zappitelli M. Acute kidney injury is an independent risk factor for pediatric intensive care unit mortality, longer length of stay and prolonged mechanical ventilation in critically ill children: a two-center retrospective cohort study. Crit Care 2011; 15(3): R146 doi: 10.1186/cc10269.

Transfusion medicine - Lacroix J, Tucci M, Tinmouth A, Gauvin F, Karam O. Transfusion medicine. Dans: Fuhrman BP, Zimmerman JJ (eds). Pediatric Critical Care, 4th edition. Toronto (Ontario). Elsevier, 2011; 1162-1176.

Association between length of storage of transfused red blood cells and multiple organ dysfunction syndrome in pediatric intensive care patients - Gauvin F, Spinella PC, Lacroix J, Choker G, Ducruet T, Karam O, Hébert P, Hutchison JS, Hume HA, Tucci M. Association between length of storage of transfused red blood cells and multiple organ dysfunction syndrome in pediatric intensive care patients. Transfusion 2010; 50(9): 1902-1913.

Acute lung injury in children: Therapeutic practice and feasibility of international clinical trials - Santschi M, Jouvet P, Leclerc F, Gauvin F, Newth CJ, Carroll CL, Flori H, Tasker R, Rimensberger P, Randolph AG, for the PALIVE Investigators, the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI), the European Society of Pediatric and Neonatal Intensive Care (ESPNIC). Acute lung injury in children: Therapeutic practice and feasibility of international clinical trials. Pediatr Crit Care Med 2010; 11(6): 681-689.

Should we avoid transfusion inthe pediatric intensive care unit? - Gauvin F, Lacroix J. Should we avoid transfusion inthe pediatric intensive care unit?. Pediatr Crit Care Med 2009; 10(3): 400-401.

Combined central and peripheral demyelination: Comparison of adult and pediatric series - Vanasse M, Adamovic T, Riou EM, Bernard G, Gauvin F. Combined central and peripheral demyelination: Comparison of adult and pediatric series. Pediatr Neurol 2009; 41: 77-78.

Critical illness polyneuromyopathy in a child with severe demyelinating myelitis - Adamovic T, Willems A, Vanasse M, D'Anjou G, Robitaille Y, Litalien C, Gauvin F. Critical illness polyneuromyopathy in a child with severe demyelinating myelitis. J Child Neurol 2009; 24(6): 758-762.

Long-term survival rate of pediatric patients after blood transfusion - Gauvin F, Lapointe H, Champagne M, Robillard P, Hume HA. Long-term survival rate of pediatric patients after blood transfusion. Pediatr Crit Care Med 2008; 48(5): 801-808.

Acute combined central and peripheral nervous system demyelination in children - Adamovic T, Riou EM, Bernard G, Vanasse M, Décarie JC, Poulin C, Gauvin F. Acute combined central and peripheral nervous system demyelination in children. Pediatr Neurol 2008; 39(5): 307-316.

Multicenter comparative study of conventional mechanical gas ventilation to tidal liquid ventilation in oleic acid injured sheep - Wolfson MR, Hirschl RB, Jackson J, Gauvin F, Foley DS, Lamm WJ, Gaughan J, Shaffer TH. Multicenter comparative study of conventional mechanical gas ventilation to tidal liquid ventilation in oleic acid injured sheep. ASAIO J 2008; 54(3): 256-269.

Lemierre syndrome: two preschool children with cerebral infarcts - case reports - Santschi M, Garel L, David M, Vanasse M, Gauvin F. Lemierre syndrome: two preschool children with cerebral infarcts - case reports. Clin Med Pediatrics 2008; 1: 13-18.

Procalcitonin and C-reactive protein as markers of bacterial infection in critically ill children at onset of systemic inflammatory response syndrome - Simon L, St-Louis P, Amre D, Lacroix J, Gauvin F. Procalcitonin and C-reactive protein as markers of bacterial infection in critically ill children at onset of systemic inflammatory response syndrome. Pediatr Crit Care Med 2008; 9(4): 407-413.

Transfusion strategies for patients in pediatric intensive care units - Lacroix J, Hébert P, Hutchison JH, Hume HA, Tucci M, Ducruet T, Gauvin F, Collet JP, Toledano B, Robillard P, Joffe A, Biarent D, Meert K, Peters MJ, on behalf of the TRIPICU investigators, for the Canadian Critical Care Trial Group, and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Transfusion strategies for patients in pediatric intensive care units. N Engl J Med 2007; 356(16): 1609-1619.

Transfusions et réactions transfusionnelles - Gauvin F, Hume HA. Transfusions et réactions transfusionnelles. Dans: Turgeon J, Bernard-Bonnin AC, Gervais P, Ovetchkine P, Gauthier M (eds). Dictionnaire de thérapeutique pédiatrique Weber, 2e édition. Boucherville. Gaëtan Morin, 2007; 1227-1234.

Crise d'asthme aiguë grave - Gauvin F, Fayon M, Laberge S, Morneau S, Lapierre J-G. Crise d'asthme aiguë grave. Dans: Lacroix J, Gauthier M, Hubert P, Leclerc F, Gaudreault P (eds). Urgences et soins intensifs pédiatriques. Montréal et Paris. Éditions du CHU Sainte-Justine et Elsevier Masson, 2007; 335-350.

Soins palliatifs - Gauvin F, Hubert P, Moulin D, Farrell CA, Carnevale F. Soins palliatifs. Dans: Lacroix J, Gauthier M, Hubert P, Leclerc F, Gaudreault P (eds). Urgences et soins intensifs pédiatriques. Montréal et Paris. Éditions du CHU Sainte-Justine et Elsevier Masson, 2007; 1169-1184.

Choc hémorragique - Orliaguet G, Gauvin F, Hume HA, Lacroix J, Hébert P. Choc hémorragique. Dans: Lacroix J, Gauthier M, Hubert P, Leclerc F, Gaudreault P (eds). Urgences et soins intensifs pédiatriques. Montréal et Paris. Éditions du CHU Sainte-Justine et Elsevier Masson, 2007; 167-186.

Infections nosocomiales - Bergeron C, Gauvin F, Hubert P. Infections nosocomiales. Dans: Lacroix J, Gauthier M, Hubert P, Leclerc F, Gaudreault P (eds). Urgences et soins intensifs pédiatriques. Montréal et Paris. Éditions du CHU Sainte-Justine et Elsevier Masson, 2007; 249-268.

Acceptable respiratory physiological limits for children during the weaning phase of mechanical ventilation - Santschi M, Gauvin F, Hatzakis G, Lacroix J, Jouvet P. Acceptable respiratory physiological limits for children during the weaning phase of mechanical ventilation. Intensive Care Med 2007; 33(2): 319-325.

Choc hypovolémique non hémorragique - Lévy A, Gauvin F. Choc hypovolémique non hémorragique. Dans: Turgeon J, Bernard-Bonnin AC, Gervais P, Ovetchkine P, Gauthier M (eds). Dictionnaire de thérapeutique pédiatrique Weber, 2e édition. Boucherville. Gaëtan Morin, 2007; 275-277.

Red blood cell transfusion in pediatric ICU - Lacroix J, Tucci M, Gauvin F. Red blood cell transfusion in pediatric ICU. Dans: Vincent JL (ed.). Yearbook of intensvie care and emergency medicine. Heidelberg. Springer-Verlag, 2007; 813-822.

Transfusion medicine - Lacroix J, Tucci M, Gauvin F, Toledano B, Hume HA. Transfusion medicine. Dans: Wheeler DS, Wong HR, Shaley TP(eds). Pediatric Critical Care Medicine: Basic science and clinical evidence. London. Springer-Verlag, 2007; 1263-1280.

Incidence of deep vein thrombosis related to peripherally inserted central catheters (PICC) in children - Dubois J, Rypens FF, Garel L, David M, Lacroix J, Gauvin F. Incidence of deep vein thrombosis related to peripherally inserted central catheters (PICC) in children. CMAJ 2007; 177(10): 1185-1190.

Transfusion in pediatric intensive care units: reply to letter to the editor - Lacroix J, Tucci M, Gauvin F. Transfusion in pediatric intensive care units: reply to letter to the editor. N Engl J Med 2007; 357: 302.

Asthme - Bérubé D, Gaudreault P, Gauvin F, Thivierge R, Turgeon J. Asthme. Dans: Turgeon J, Bernard-Bonnin AC, Gervais P, Ovetchkine P, Gauthier M (eds). Dictionnaire de thérapeutique pédiatrique Weber, 2e édition. Boucherville. Gaëtan Morin, 2007; 185-198.

Abords des voies aériennes - Girouard GR, Despond O, Gauvin F, Lapierre J-G. Abords des voies aériennes. Dans: Lacroix J, Gauthier M, Hubert P, Leclerc F, Gaudreault P (eds). Urgences et soins intensifs pédiatriques. Montréal et Paris. Éditions du CHU Sainte-Justine et Elsevier Masson, 2007; 1187-1205.

Risk factors of acute renal failure in critically ill children: a prospective descriptive epidemiological study - Bailey D, Phan V, Litalien C, Ducruet T, Mérouani A, Lacroix J, Gauvin F. Risk factors of acute renal failure in critically ill children: a prospective descriptive epidemiological study. Pediatr Crit Care Med 2007; 8(1): 29-35.

Choc hémorragique - Dugas M-A, D'Angelo A, Gauvin F. Choc hémorragique. Dans: Turgeon J, Bernard-Bonnin AC, Gervais P, Ovetchkine P, Gauthier M (eds). Dictionnaire de thérapeutique pédiatrique Weber, 2e édition. Boucherville. Gaëtan Morin, 2007; 271-275.

Choc anaphylactique et autres réactions allergiques graves - Verrijckt A, Mazer B, Toledano B, Gauvin F. Choc anaphylactique et autres réactions allergiques graves. Dans: Lacroix J, Gauthier M, Hubert P, Leclerc F, Gaudreault P (eds). Urgences et soins intensifs pédiatriques. Montréal et Paris. Éditions du CHU Sainte-Justine et Elsevier Masson, 2007; 241-248.

Acute transfusion reactions in pediatric intensive care unit - Gauvin F, Lacroix J, Robitaille P, Lapointe H, Hume HA. Acute transfusion reactions in pediatric intensive care unit. Transfusion 2006; 46(11): 1899-1908.

Systemic capillary leak syndrome presenting as recurrent shock - Karatzios C, Gauvin F, Egerszegi PE, Tapiero B, Buteau C, Rivard G-É, Ovetchkine P. Systemic capillary leak syndrome presenting as recurrent shock. Pediatr Crit Care Med 2006; 7(4): 377-379.

Nosocomial infection in the Pediatric Intensive Care Unit: Epidemioloy and control - Lacroix J, Gauvin F, Skippen P, Cox P, Langley JM, Matlow A. Nosocomial infection in the Pediatric Intensive Care Unit: Epidemioloy and control. Dans: Fuhrman BP, Zimmerman JJ (eds). Pediatric Critical Care, 3rd edition. St-Louis. Mosby Year Book, 2006; 1294-1342.

Determinants of red blood cell transfusion in Pediatric Intensive Care Unit: a prospective epidemiologic study - Armano R, Gauvin F, Ducruet T, Lacroix J. Determinants of red blood cell transfusion in Pediatric Intensive Care Unit: a prospective epidemiologic study. Crit Care Med 2005; 33(11): 2637-2644.

The syndrome of amniotic fluid embolization: A potential contribution of bradykinin - Robillard J, Gauvin F, Molinaro G, Leduc L, Adam A, Rivard G-É. The syndrome of amniotic fluid embolization: A potential contribution of bradykinin. Am J Obstet Gynecol 2005; 193(4): 1508-1512.

Reply to Knudsen and Kristiansen - Simon L, Gauvin F, Amre D, St-Louis P, Lacroix J. Reply to Knudsen and Kristiansen. Clin Infect Dis 2005; 40(9): 1373-1374; erratum 1386-1388.

Fatal diffuse capillaritis after hematopoietic stem-cell transplantation for dyskeratosis congenita despite low-intensity conditioning regimen - Brazzola P, Duval M, Fournet JC, Gauvin F, Dalle JH, Champagne J, Champagne M. Fatal diffuse capillaritis after hematopoietic stem-cell transplantation for dyskeratosis congenita despite low-intensity conditioning regimen. Bone Marrow Transplant 2005; 36(12): 1103-1105.

Transfusion of blood products: When, why and how - Lacroix J, Hume HA, Gauvin F, Severinii MH. Transfusion of blood products: When, why and how. Dans: Piva JP, Garcia PCR (eds). Medicina intensiva em Pediatra, 5e édition. Rio de Janiero. Editora Medsi, 2005; 216-246.

Cumulative influence of organ dysfunctions and septic state on mortality of critically ill children - Leclerc F, Leteurtre S, Duhamel A, Grandbastien B, Proulx F, Martinot A, Gauvin F, Hubert P, Lacroix J. Cumulative influence of organ dysfunctions and septic state on mortality of critically ill children. Am J Respir Crit Care Med 2005; 171(4): 348-353.

Serum procalcitonin and C-reactive protein as markers of bacterial infection: A systematic review and meta-analysis - Simon L, Gauvin F, Amre D, St-Louis P, Lacroix J. Serum procalcitonin and C-reactive protein as markers of bacterial infection: A systematic review and meta-analysis. Clin Infect Dis 2004; 39(2): 206-217.

Soins palliatifs en soins intensifs pédiatriques - Farrell CA, Gauvin F, Hubert P. Soins palliatifs en soins intensifs pédiatriques. Dans: Humbert N (ed). Les soins palliatifs pédiatriques. Collection Intervenir. Montréal, Qc. Éditions de l'Hôpital Sainte-Justine, 2004; 309-342.

Fin de vie en réanimation pédiatrique - Hubert P, Gauvin F, Cremer R. Fin de vie en réanimation pédiatrique. Dans: Boles JM, Lemaire F (eds). Fin de vie en réanimation. Collection Réanimation. Europe. Elsevier, 2004; XX.

Red blood cell transfusion practices in pediatric critical care - Lacroix J, Tucci M, Gauvin F. Red blood cell transfusion practices in pediatric critical care. Transfus Altern Transfus Med 2004; 6(2): 22-26.

Soins palliatifs et soins intensifs pédiatriques: un paradoxe? - Gauvin F, Farrell CA. Soins palliatifs et soins intensifs pédiatriques: un paradoxe?. Le Clinicien 2003; 18: 80-86.

Ventilator-associated pneumonia in intubated children: comparison of different diagnostic methods - Gauvin F, Dassa C, Chaïbou M, Proulx F, Farrell CA, Lacroix J. Ventilator-associated pneumonia in intubated children: comparison of different diagnostic methods. Pediatr Crit Care Med 2003; 4(4): 437-443.

The habit and the hub (éditorial) - Lacroix J, Gauvin F. The habit and the hub (éditorial). Crit Care Med 2003; 31(5): 1583-1584.

Naloxone for patients in shock (Cochrane Review) - Boeuf B, Poirier V, Gauvin F, Guerguerian A-M, Roy CC, Farrell CA, Lacroix J. Naloxone for patients in shock (Cochrane Review). Dans: The Cochrane Library. Chichester, UK. John Wiley Sons, Ltd, 2003; Issue 4.

Book review: Nosocomial infections - Gauvin F, Lacroix J. Book review: Nosocomial infections. Crit Care Med 2002; 30(3): 724-725.

Reproductivity of blind protected bronchoalveolar lavage in mechanically-ventilated children - Gauvin F, Lacroix J, Guertin M-C, Proulx F, Farrell CA, Moghrabi A, Lebel P, Dassa C. Reproductivity of blind protected bronchoalveolar lavage in mechanically-ventilated children. Am J Respir Crit Care Med 2002; 165(12): 1618-1623.

Survey of transfusion practices of pediatric intensive care units - Laverdière C, Gauvin F, Hébert P, Infante-Rivard C, Hume HA, Toledano B, Guertin M-C, Lacroix J, and the Canadian Critical Care Trial Group. Survey of transfusion practices of pediatric intensive care units. Pediatr Crit Care Med 2002; 3(4): 335-340.

Fin de vie en réanimation pédiatrique: expérience canadienne - Millotte B, Farrell CA, Gauvin F, Lacroix J. Fin de vie en réanimation pédiatrique: expérience canadienne. Dans: Dhainault JF (ed). Actualités en Réanimation et Urgences. Paris. Arnette, 2002; 385-392.

Simple intravenous antimicrobial desentization method for pediatric patients - De Maria C, Lebel D, Des Roches A, Gauvin F. Simple intravenous antimicrobial desentization method for pediatric patients. Am J Health Syst Pharm 2002; 59(16): 1532-1536.

The impact of clinically significant upper gastrointestinal bleeding acquired in a pediatric intensive care unit - Gauvin F, Dugas M-A, Chaïbou M, Morneau S, Lebel D, Lacroix J. The impact of clinically significant upper gastrointestinal bleeding acquired in a pediatric intensive care unit. Pediatr Crit Care Med 2001; 2: 294-298.

Hospitalizations for pediatric intoxications in Washington state from 1987 to 1997 - Gauvin F, Bailey B, Bratton SL. Hospitalizations for pediatric intoxications in Washington state from 1987 to 1997. Arch Pediat Adol Med 2001; 155(10): 1105-1110.

Hypotensive reaction associated with platelet transfusion through leukocyte reduction filte - Gauvin F, Toledano B, Hume HA, Lacroix J. Hypotensive reaction associated with platelet transfusion through leukocyte reduction filte. J Intensive Care Med 2000; 15: 329-332.

Pratiques de transfusion de concentré globulaire en réanimation pédiatrique - Gauvin F, Chaïbou M, Leteurtre S, Toledano B, Hume HA, Proulx F, Hébert P, Martinot A, Leclerc F, Lacroix J. Pratiques de transfusion de concentré globulaire en réanimation pédiatrique. Réan Urg 2000; 9: 339-344.

Reactive hemophagocytic syndrome presenting as a component of multiple dysfunction syndrome - Gauvin F, Toledano B, Champagne J, Lacroix J. Reactive hemophagocytic syndrome presenting as a component of multiple dysfunction syndrome. Crit Care Med 2000; 28(9): 3341-3345.

Development of a pediatric multiple organ dysfunction score. Use of two strategies - Leteurtre S, Martinot A, Duhamel A, Gauvin F, Grandbastien B, Nam TV, Proulx F, Lacroix J. Development of a pediatric multiple organ dysfunction score. Use of two strategies. Med Decis Making 1999; 19: 399-410.

Maladies obstructives laryngo-tranchéales chroniques ou récidivantes chez l'enfant - Gauvin F, Quintal MC, Farrell CA, Bergeron S, Lacroix J. Maladies obstructives laryngo-tranchéales chroniques ou récidivantes chez l'enfant. Med Ther Ped 1998; 1(5): 419-425.

Therapy of shock with naloxone: a meta-analysis - Boeuf B, Gauvin F, Guerguerian A-M, Farrell CA, Lacroix J, Jenicek M. Therapy of shock with naloxone: a meta-analysis. Crit Care Med 1998; 26(11): 1910-1916.

Nosocomial infection: Diagnostic criteria - Lacroix J, Gauvin F. Nosocomial infection: Diagnostic criteria. Dans: Fatima DM, Freire M, Sapolnik R, Araujo K (eds). Actualizaçao em Terapia Intensiva Pediatrica. Salvador. P & A Grafia e Editora Ltd, 1998; 81-101.

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