Chercheur

    Luc Laurier Oligny , M.D. , Ph.D.

    luc_oligny@ssss.gouv.qc.ca
    Luc Laurier Oligny
    Axe de recherche
    Pathologies fœtomaternelles et néonatales
    Thème de recherche
    Étude des mécanismes des malformations congénitales
    Adresse
    CHUSJ

    Téléphone
    514 345-4931 #4649

    Fax
    514 345-4819

    Titres

    • Directeur adjoint, Affaires cliniques, Département de pathologie et biologie cellulaire, Université de Montréal, 2006.
    • Professeur agrégé, Département de pathologie et biologie cellulaire, Faculté de médecine, Université de Montréal, 2004.
    • Chef, Département de pathologie, CHU Sainte-Justine, 2001.

    Formation

    • Postdoctorat en pathologie pédiatrique et pathologie moléculaire et cytogénétique, Hôpital pour enfants de Vancouver, Colombie-Britannique, 1994.
    • Doctorat en pathologie, Université McGill, 1992.
    • Doctorat en médecine, Université McGill, 1986.
    • Maîtrise en pathologie, Université McGill, 1983.

    Intérêts de recherche

    • La morphométrie placentaire et le retard de croissance intra-utérine (RCIU) ainsi que la corrélation avec les données cliniques incluant le devenir à long terme.
    • Les mécanismes épigénétiques de la régulation de l’expression des gènes dans le cancer et dans le développement embryonnaire normal, particulièrement en ce qui a trait aux rôles des gènes IGF2 et H19.
    • La cellule myoépithéliale du sein humain dans le développement fœtal et dans le cancer.
    • Les infections dues au virus du papillome humain (VPH) chez les enfants et les adultes.

    Sommaire de carrière

    • Cours d'embryologie médicale donné aux étudiants en médecine (20 heures portant sur les aspects morphologiques, moléculaires et cliniques du développement - manuel en cours de rédaction) et aux étudiants de premier cycle (45 heures).
    • Cours de génétique médicale donné aux étudiants en médecine ainsi qu’aux étudiants des cycles supérieurs.
    • Rédacteur adjoint de la 2e édition de Potter's Pathology of the Fetus, Infant and Child, publié par Mosby Elsevier en mars 2007.
    • Membre du comité éditorial de la revue Pediatric and Developmental Pathology depuis janvier 2006.

Publications

Fetal and perinatal autopsy in prenatally diagnosed fetal abnormalities with normal karyotype - Desilets V, Oligny LL, Audibert F, Genetics Committee of the Society of Obstetricians and Gynaecologists of Canada(SOGC), Family Physicians Advisory Committee, Medico–Legal Committee of the SOGC. Fetal and perinatal autopsy in prenatally diagnosed fetal abnormalities with normal karyotype. J Obstet Gynaecol Can 2011; 33(10): 1047-1057.

High level of apoptosis and low AKT activation in mass screening as opposed to standard neuroblastoma - Sartelet H, Ohta S, Barrette S, Rougemont A-L, Brevet M, Regairaz M, Harvey I, Bernard C, Fabre M, Gaboury L, Oligny LL, Bosq J, Valteau-Couanet D, Vassal G. High level of apoptosis and low AKT activation in mass screening as opposed to standard neuroblastoma. Histopathology 2010; 56(5): 607-616.

Development and description of GETT: a genetic testing evidence tracking tool - Rousseau F, Lindsay C, Charland M, Labelle Y, Bergeron J, Blancquaert I, Delage R, Gilfix B, Miron M, Mitchell GA, Oligny LL, Pazzagli M, Mamotte C, Payne D, IFCC Scientific Division Committee on Molecular Diagnostics. Development and description of GETT: a genetic testing evidence tracking tool. Clin Chem Lab Med 2010; 48(10): 1397-1407.

[Juvenile xanthogranuloma of the nasal cavity] - Chami R, Aleynikova O, Abela A, Blais M, Oligny LL, Bouron-Dal Soglio D, Patey N. [Juvenile xanthogranuloma of the nasal cavity]. Ann Pathol 2010; 30(5): 374-377.

Lethal respiratory failure and mild primary hypothyroidism in a term girl with a de novo heterozygous mutation in the TITF1/NKX2.1 gene - Maquet E, Costagliola S, Parma J, Christophe-Hobertus C, Oligny LL, Fournet JC, Robitaille Y, Vuissoz JM, Payot A, Laberge S, Vassard G, Van Vliet G, Deladoëy J. Lethal respiratory failure and mild primary hypothyroidism in a term girl with a de novo heterozygous mutation in the TITF1/NKX2.1 gene. J Clin Endocrinol Metab 2009; 94(1): 197-203.

AKT pathway in neuroblastoma and its therapeutic implication - Sartelet H, Oligny LL, Vassal G. AKT pathway in neuroblastoma and its therapeutic implication. Expert Rev Anticanc Ther 2008; 8(5): 757-769.

Collapsing glomerulopathy in Galloway-Mowat syndrome: a case report and review of the literature - Sartelet H, Pietrement C, Noël L, Sabouraud P, Birembaut P, Oligny LL, Roussel B, Doco-Fenzy M. Collapsing glomerulopathy in Galloway-Mowat syndrome: a case report and review of the literature. Pathol Res Pract 2008; 204(6): 401-406.

A B-cell lymphoma-associated chromosomal translocation in a progressive transformation of germinal center - Bouron-Dal Soglio D, Truong F, Fetni R, Hazourli S, Champagne J, Oligny LL, Fournet JC. A B-cell lymphoma-associated chromosomal translocation in a progressive transformation of germinal center. Hum Pathol 2008; 39(2): 292-297.

Caudal dysgenesis, sirenomelia, and situs inversus totalis: A primitive defect in blastogenesis - Rougemont A-L, Bouron-Dal Soglio D, Desilets VA, Jovanovic M, Perreault G, Oligny LL, Fournet JC. Caudal dysgenesis, sirenomelia, and situs inversus totalis: A primitive defect in blastogenesis. Am J Med Genet A 2008; 146A(11): 1470-1476.

Presence of autoantibodies against tubular and uveal cells in a patient with tubulointerstitial nephritis and uveitis (TINU) syndrome - Abel L, Mérouani A, Haddad E, Benoit G, Oligny LL, Sartelet H. Presence of autoantibodies against tubular and uveal cells in a patient with tubulointerstitial nephritis and uveitis (TINU) syndrome. Nephrol Dial Transpl 2008; 23(4): 1452-1455.

Disorders of the anterior thoracic and abdominal walls - Oligny LL. Disorders of the anterior thoracic and abdominal walls. Dans: Gilbert-Barness E, Kapur R, Oligny LL, Siebert J (eds). Potter's Pathology of the Fetus, Infant and Child, 2nd edition. Mosby-Elsevier, 2007; 919-942.

Chromosomal abnormalities - Gilbert-Barness E, Oligny LL, Fetni R, Lemieux N. Chromosomal abnormalities. Dans: Gilbert-Barness E, Kapur R, Oligny LL, Siebert J (eds). Potter's Pathology of the Fetus, Infant and Child, 2nd edition. Mosby-Elsevier, 2007; 205-267.

Mechanisms of development and growth: Molecular genetics - Wilson GN, Oligny LL. Mechanisms of development and growth: Molecular genetics. Dans: Gilbert-Barness E, Kapur R, Oligny LL, Siebert J (eds). Potter's Pathology of the Fetus, Infant and Child, 2nd edition. Mosby-Elsevier, 2007; 3-64.

Chromosomal abnormalities - Gilbert-Barness E, Oligny LL. Chromosomal abnormalities. Dans: Gilbert-Barness E, Kapur R, Oligny LL, Siebert J (eds). Potter's Pathology of the Fetus, Infant and Child, 2nd edition. Mosby-Elsevier, 2007; 213-276.

Pathology of abortion: The embryo and previable fetus - Kalousek DK, Oligny LL. Pathology of abortion: The embryo and previable fetus. Dans: Gilbert-Barness E, Kapur R, Oligny LL, Siebert J (eds). Potter's Pathology of the Fetus, Infant and Child, 2nd edition. Mosby-Elsevier, 2007; 277-306.

Potter's Pathology of the Fetus, Infant and Child, 2nd edition - Gilbert-Barness E, Kapur R, Oligny LL, Siebert J, e. Potter's Pathology of the Fetus, Infant and Child, 2nd edition. Mosby-Elsevier, 2007; 2245 pages.

Accessory liver lobe with mesothelial inclusion cysts in an omophalocele: a new malformative association - Rougemont A-L, Sartelet H, Oligny LL, Bensoussan A, Yazbeck S, Fournet JC. Accessory liver lobe with mesothelial inclusion cysts in an omophalocele: a new malformative association. Pediatr Dev Pathol 2007; 10(3): 224-228.

Exaggerated vasomotor response to angiotensin II in rats with fetal programming of hypertension associated with exposure to a low protein diet during gestation - Yzydorczyk C, Gobeil F, Cambonie G, Lahaie I, Le NL, Samarani S, Ahmad A, Lavoie JC, Oligny LL, Hardy P, Nuyt A-M. Exaggerated vasomotor response to angiotensin II in rats with fetal programming of hypertension associated with exposure to a low protein diet during gestation. Am J Physiol Regul Integr Comp Physiol 2006; 291(4): R1060-R1068.

Pediatric anogenital warts: a 7-year review of children referred to a tertiary-care hospital in Montreal, Canada - Marcoux D, Nadeau K, McCuaig C, Powell J, Oligny LL. Pediatric anogenital warts: a 7-year review of children referred to a tertiary-care hospital in Montreal, Canada. Pediatr Dermatol 2006; 23(3): 199-207.

Bilateral cystic dysplasia of the rete testis with renal adysplasia - Bouron-Dal Soglio D, Harvey I, Jovanovic M, Oligny LL, Fournet JC. Bilateral cystic dysplasia of the rete testis with renal adysplasia. Pediatr Dev Pathol 2006; 9(2): 157-160.

An association of pleuropulmonary blastoma and cystic nephroma: possible genetic association - Bouron-Dal Soglio D, Harvey I, Yazbeck S, Rypens FF, Oligny LL, Fournet JC. An association of pleuropulmonary blastoma and cystic nephroma: possible genetic association. Pediatr Dev Pathol 2006; 9(1): 61-64.

Intrahepatic biliary cysts presenting before hepatic portoenterostomy in biliary atresia - Mas E, Alvarez F, Oligny LL, Martin S. Intrahepatic biliary cysts presenting before hepatic portoenterostomy in biliary atresia. J Pediatr Gastroenterol Nutr 2006; 42(2): 440-442.

Best cases from the AFIP - Cardiac metastases from melanoma - Tesolin H, Lapierre C, Oligny LL, Bigras JL, Champagne M. Best cases from the AFIP - Cardiac metastases from melanoma. Radiographics 2005; 25(1): 249-253.

Prenatal diagnosis of cloverleaf skull: watch the hands! - Gorincour G, Rypens FF, Grignon A, Garel L, Bortoluzzi P, Oligny LL, Lemyre E, Duperron L. Prenatal diagnosis of cloverleaf skull: watch the hands!. Fetal Diagn Ther 2005; 20(4): 296-300.

A large unilateral renal artery aneurysm in a young child - Robitaille P, Dubois J, Rypens FF, Oligny LL, Lors H. A large unilateral renal artery aneurysm in a young child. Pediatr Radiol 2004; 34(3): 253-255.

Sudden death in growth hormone-treated children with Prader-Willi syndrome - Van Vliet G, Deal C, Crock P, Robitaille Y, Oligny LL. Sudden death in growth hormone-treated children with Prader-Willi syndrome. J Pediatr 2004; 144(1): 129-131.

Unilobar congenital pulmonary lymphangiectasis mimicking congenital lobar emphysema: an underestimated presentation? - Chapdelaine J, Beaunoyer M, St-Vil D, Oligny LL, Garel L, Butter A, Di Lorenzo M. Unilobar congenital pulmonary lymphangiectasis mimicking congenital lobar emphysema: an underestimated presentation?. J Pediatr Surg 2004; 39(4): 677-680.

Characterization and distribution of colonic dendritic cells in Crohn's Disease - Silva M, Lopez C, Riverin F, Oligny LL, Menezes J, Seidman EG. Characterization and distribution of colonic dendritic cells in Crohn's Disease. Inflamm Bowel Dis 2004; 10(5): 504-512.

Molecular embryogenesis - an overview - Oligny LL. Molecular embryogenesis - an overview. Dans: Kalousek DK, Dimmick JE (eds). Perspectives in Pediatric Pathology. Springer Publishers, 2003; 19-38.

Cancer and epigenesis - a developmental perspective - Oligny LL. Cancer and epigenesis - a developmental perspective. Adv Pediatrics 2003; 50: 59-80.

Cytokine tissue levels as markers of disease activity in pediatric Crohn's diseases - Silva M, Menezes J, Wizman S, Gendron R, Oligny LL, Seidman EG. Cytokine tissue levels as markers of disease activity in pediatric Crohn's diseases. Pediatr Res 2003; 54(4): 456-461.

Basal cells of second trimester fetal breasts: immunohistochemical study of myoepithelial precursors - Jolicoeur F, Gaboury L, Oligny LL. Basal cells of second trimester fetal breasts: immunohistochemical study of myoepithelial precursors. Pediatr Dev Pathol 2003; 6(5): 398-413.

Intrauterine growth restriction in rats is associated with hypertension and renal dysfunction in adulthood - Battista MC, Oligny LL, St-Louis J, Brochu M. Intrauterine growth restriction in rats is associated with hypertension and renal dysfunction in adulthood. Am J Physiol Endocrinol Metab 2002; 283(1): E124-E131.

Cardiac pathology in sudden unexpected infant death - Dancea A, Côté A, Rohlicek C, Bernard C, Oligny LL. Cardiac pathology in sudden unexpected infant death. J Pediatr 2002; 141(3): 336-342.

Multifocal, nascent and invasive myoepithelial carcinoma (malignant myoepithelioma) of the breast: An immunohistochemical and ultrastructural study - Jolicoeur F, Seemayer TA, Gabbiani G, Robidoux A, Gaboury L, Oligny LL, Schürch W. Multifocal, nascent and invasive myoepithelial carcinoma (malignant myoepithelioma) of the breast: An immunohistochemical and ultrastructural study. Int J Surg Pathol 2002; 10(4): 281-291.

Cancer and epigenesis - an overview - Oligny LL. Cancer and epigenesis - an overview. Ann Diagn Paed Pathol 2001; 5: 27-30.

Cancer and epigenesis - an overview - Oligny LL. Cancer and epigenesis - an overview. Pediatr Dev Pathol 2001; 4(4): 324-343.

Human molecular embryogenesis: an overview - Oligny LL. Human molecular embryogenesis: an overview. Pediatr Dev Pathol 2001; 4(4): 324-343.

Human papillomavirus PCR-direct sequencing study of cervical precancerous lesions in Quebec children - Oligny LL, Feoli-Fonseca J-C, Brochu P, Simard P, Falconi S, Yotov WV. Human papillomavirus PCR-direct sequencing study of cervical precancerous lesions in Quebec children. Sex Transm Infect 2001; 77(5): 391.

Human papillomavirus (HPV) study of 691 pathological specimens from Quebec by PCR-direct sequencing approach - Feoli-Fonseca J-C, Oligny LL, Brochu P, Simard P, Falconi S, Yotov WV. Human papillomavirus (HPV) study of 691 pathological specimens from Quebec by PCR-direct sequencing approach. J Med Virol 2001; 63(4): 284-292.

Molecular characterization of a pediatric pheochromocytoma with suspected bilateral disease - Mircescu H, Wilkin F, Paquette J, Oligny LL, Decaluwé H, Gaboury L, Nolet S, Van Vliet G, Deal C. Molecular characterization of a pediatric pheochromocytoma with suspected bilateral disease. J Pediatr 2001; 138(2): 269-273.

The adipose tissue phenotype of hormone-sensitive lipase deficiency in mice - Wang SP, Laurin N, Himms-Hagen J, Rudnicki M, Levy E, Robert M-F, Pan L, Oligny LL, Mitchell GA. The adipose tissue phenotype of hormone-sensitive lipase deficiency in mice. Obes Res 2001; 9(2): 119-128.

Pediatric adrenocortical tumors : molecular events leading to insulin-like growth factor-II overexpression - Wilkin F, Gagné N, Paquette J, Oligny LL, Deal C. Pediatric adrenocortical tumors : molecular events leading to insulin-like growth factor-II overexpression. J Clin Endocrinol Metab 2000; 85: 2048-2056.

Hyperfunctioning malignant thyroid nodule in an eleven-year-old girl: Pathological and molecular study - Mircescu H, Parma J, Huot C, Deal C, Oligny LL, Vassard G, Van Vliet G. Hyperfunctioning malignant thyroid nodule in an eleven-year-old girl: Pathological and molecular study. J Pediatr 2000; 137(4): 585-587.

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