Chercheur

    Caroline Quach-Thanh , M.D. , FRCPC , M.Sc.

    c.quach@umontreal.ca
    Caroline Quach-Thanh
    Axe de recherche
    Maladies infectieuses et soins aigus
    Thème de recherche
    Prévention des infections
    Adresse
    CHUSJ - Centre de Recherche Bureau B.17.102

    Titres

    • Professeure agrégée, Département de microbiologie, infectiologie et immunologie, Université de Montréal
    • Pédiatre microbiologiste infectiologue
    • Médecin responsable, Prévention et contrôle des infections, CHUSJ
    • Directeur médical pédiatrique, OPTILAB Montréal-CHUM

    Formation

    • M.Sc. Épidémiologie (McGill) - 2003
    • M.D. (Université de Montréal) - 1995
    • Diplômes :
      • Collège des médecins du Québec –   
        Pédiatrie (1999); Microbiologie-Infectiologie - 2002
    • Fellow du Collège royal des médecinsdu Canada (FRCPC) :
      • Pédiatrie (1999); Maladies infectieuses pédiatriques (2001); Microbiologie médicale (2002)

    Expertises de recherche

    1. Épidémiologie
    2. Immunisation
    3. Infections noscomiales
    4. Recherche évaluative
    5. Microbiologie

    Sommaire de carrière

    Le Dr Caroline Quach est pédiatre, microbiologiste-infectiologue et professeur agrégé au département de Microbiologie, infectiologie et immunologie de l’Université de Montréal. Elle est le médecin responsable de la prévention et du contrôle des infections au CHU Sainte-Justine et la directrice médicale pédiatrique Optilab Montréal-CHUM. Elle est également médecin-conseil à l'Institut national de santé publique du Québec (INSPQ) dans la Direction des risques biologiques et de la santé au travail (immunisation et prévention des infections).

    Le Dr Quach est diplômée de la Faculté de médecine de l'Université de Montréal, a complété sa résidence en pédiatrie au CHU Sainte-Justine et sa formation post-graduée en microbiologie-infectiologie à l'Université McGill où elle a travaillé pendant plus de 10 ans. Elle est chercheur clinicien avec support salarial du FRQ-S (sénior).

    Ses intérêts de recherche sont axés sur l’immunisation ainsi que la compréhension des facteurs de risque et la prévention des infections nosocomiales (associées aux soins de santé) et la prévention de l’antibiorésistance, en particulier dans les populations vulnérables (prématurés, immunocompromis, fibrose kystique).

    Prix et distinctions

    International                   

    • ID Week 2017 Mentor (San Diego, CA) – Oct. 2017
    • ID Week 2016 Mentor (New Orleans, LA) – Oct. 2016
    • 2015 Society of Healthcare Epidemiology of America (SHEA) William Jarvis Award (meilleure publication internationale publiée dans Infection Control Hospital Epidemiology en 2014 pour le manuscrit: Quach C*, Milstone AM, Perpete C, Bonenfant M, Moore DL, Perreault T. Chlorhexidine Bathing in a Tertiary-Care Neonatal Intensive Care Unit: Impact on Central Line Associated Bloodstream Infections. Infect Control Hospit Epidemiol 2014; 35: 158-63).
    • ID Week 2015 Mentor (San Diego, CA) – Oct. 2015
    • Fellow of the Society of Healthcare Epidemiology of America (FSHEA) – (2014)

    National                             

    • 2016 John Embil Mentorship Award in Infectious Diseases (Canadian Foundation for Infectious Diseases)

    Local                                    

    • Prix pour l’excellence en recherche de la Fondation de l’Hôpital de Montréal pour enfants (2014)

    Présentations

    1. ESPID 2018 - Use of microbiological methods to prevent, control and trace spread of infections in children (in hospital settings), Malmö, Sweden (juin 2018)
    2. Nosocomial Infections in Maternity Hospitals – International keynote speaker, Sao Paulo, Brazil (mars 2018)
    3. Maximizing the impact of immunization programs in Canada: bridging the gap between research and policy – Integration of Research into Policy (mai 2017)
    4. EEROVAC 2017 – Rotavirus Vaccination in NICU Settings, UMC Utrecht, Utrecht, The Netherlands (mars 2017)
    5. ID Week 2016 – Infection Prevention in the NICU : Small but mighty! Pediatric Infection Prevention Symposium plenary session « Pediatric Infection Prevention : Keeping Healthy Chldren In and Pathogens Out », New Orleans LA (octobre 2016)
    6. Canadian Respiratory Conference 2016 – Pneumococcal Vaccines  (avril 2016)
    7. Opening lecture - Education Program for Immunization Competencies, The Canadian Pediatric Society (avril 2016)

    Publications choisies

    1. Martineau C, Li X, Lalancette C, Perreault T, Fournier E, Tremblay J, Gonzales M, Yergeau É, Quach C. Serratia marcescens outbreak in a neonatal intensive care unit (NICU): new insights from next-generation sequencing applications. J Clin Microbiol. 2018 Jun 13. pii: JCM.00235-18. doi: 10.1128/JCM.00235-18. [Epub ahead of print]
    2. Merckx J, Ducharme FM, Martineau C, Zemek R, Gravel J, Chalut D, Poonai N, Quach C; Respiratory Viruses and Treatment Failure in Children With Asthma Exacerbation. Pediatric Emergency Research Canada (PERC) DOORWAY team. Pediatrics. 2018 Jul;142(1). pii: e20174105. doi: 10.1542/peds.2017-4105. Epub 2018 Jun 4.
    3. Doll MK, Quach C, Buckeridge DL. Evaluation of the Impact of a Rotavirus Vaccine Program on Pediatric Acute Gastroenteritis Hospitalizations: Estimating the Overall Effect Attributable to the Program as a Whole, and as a Per-Unit Change in Rotavirus Vaccine Coverage. Am J Epidemiol. 2018 May 11. doi: 10.1093/aje/kwy097. [Epub ahead of print]
    4. Tilmanne A, Martiny D, Hallin M, Cornelius A, Wautier M, Quach C, Lepage P, Vandenberg O. Campylobacter concisus and Acute Gastroenteritis in Children: Lack of Association. Pediatr Infect Dis J. 2018 Mar 29. doi: 10.1097/INF.0000000000002028. [Epub ahead of print]
    5. Trudel K, Zavalkoff S, Winters N, Quach C, Lacroix J, Fontela PS. Determinants of urinary catheter removal practices in the pediatric intensive care unit: A survey. Am J Infect Control. 2018 Jun;46(6):627-632. doi: 10.1016/j.ajic.2017.12.020. Epub 2018 Mar 5.
    6. O’Donnell S, Dubé E, Tapiero B, Gagneur A, Doll MK, Quach C*. Determinants of under-immunization and cumulative time spent under-immunized in a Quebec cohort. Vaccine 2017; 35: https://doi.org/10.1016/j.vaccine.2017.08.072
    7. Auger N, Quach C, Healy-Profitos J, Dinh T, Chassé M. Early Predictors of Guillain-Barré Syndrome in Women. International Journal of Epidemiology 2017; dyx181, https://doi.org/10.1093/ije/dyx181.
    8. Auger N, Quach C, Healy-Profitos J, Lowe AM, Arbour L. Congenital microcephaly in Quebec: baseline prevalence, risk factors and outcomes in a large cohort of neonates. Archives Dis Child Fetal Neonatal Ed.  2017 Jul 4. pii: fetalneonatal-2016-311199. doi: 10.1136/archdischild-2016-311199. [Epub ahead of print]
    9. Boikos C, Joseph L, Scheifele D, Lands LC, De Serres G, Papenburg J, Winters N, Chilvers M, Quach C*. Adverse Events Following Live-Attenuated Intranasal Influenza Vaccination of Children with Cystic Fibrosis: Results from Two Influenza Seasons. Vaccine 2017; 35 : 5019-5026.
    10. Kraicer-Melamed H., Quach C. Expanding free school-based Human Papilloma Virus (HPV) vaccination programs to include school-aged males in Nova Scotia, Canada. Health Reform Observer – Observatoire des Réformes de Santé 2017; [S.l.], v. 5, n. 2, june 2017. ISSN 2291-6369. Available at: <https://mulpress.mcmaster.ca/hro-ors/article/view/2851>. Date accessed: 12 july 2017. doi:https://doi.org/10.13162/hro-ors.v5i2.2851
    11. Johnson J, Quach C*. Outbreaks in the Neonatal Intensive Care Unit: A Review of the Literature. Current Opinion in Infectious Diseases 2017; 30: 395-403
    12. Fontela PS, Quach C, Karim M, Willson DF, Gilfoyle E, McNally JD, Gonzales M, Papenburg J, Reynolds S, Lacroix J, Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) network, on behalf of the Canadian Critical Care Trials Group. Determinants of Antibiotic Tailoring In Pediatric Intensive Care: a National Survey. Pediatric Critical Care Medicine 2017 [Epub ahead of print].
    13. Berman M, Dube E, Quach C*. Exploring the Acceptability of the Available Pneumococcal Conjugate Vaccines in Canadian Health Care Professionals and Immunization Experts. Vaccine 2017; 35: 3326-3332.
    14. Boikos C, Papenburg J, Martineau C, Joseph L, Scheifele D, Chilvers M, Lands LC, De Serres G, Quach C*. Viral Interference and the Live-Attenuated Intranasal Influenza Vaccine: Results from a Pediatric Cohort with Cystic Fibrosis. Human Vaccines Immunother 2017; 13 : 1-7. doi: 10.1080/21645515.2017.1287641. [Epub ahead of print]
    15. Blanchard AC, Fortin E, Laferriere C, Goyer I, Moussa A, Autmizguine J, Quach C*. Comparative effectiveness of linezolid versus vancomycin as definitive antibiotic therapy for heterogeneous vancomycin-intermediate coagulase negative staphylococcal central-line associated blood infections in a neonatal intensive care unit. J Antimicrob Chemother 2017; 72 : 1812-1817.
    16. Boikos C, Caya C, Doll M, Kraicer-Melamed H, Dolph M, DeLisle G, Winters N, Gore G, Quach C*. Safety and Effectiveness of Neuraminidase Inhibitors in Situations of Pandemic and/or Novel/Variant Influenza: A Systematic Review of the Literature, 2009-2015. J Antimicrob Chemother 2017; 72: 1556-1573.
    17. Quach C*, Shah R, Rubin L. Burden of Healthcare-Associated Viral Respiratory Infections in Children’s Hospitals. J Pediatr Infect Dis Soc 2016; pii: piw072. doi: 10.1093/jpids/piw072.  [Epub ahead of print].
    18. Top KA, Billard MN, Gariepy MC, Rouleau I, Pernica J, Pham-Huy A, Quach C, Tran D, Vaudry W, Dobson S, Boucher FD, Carignan A, Diaz-Mitoma F, Jadavji T, McConnell A, McNeil, Halperin SA, De Serres G, for the Canadian Immunization Research Network (CIRN) investigators. Immunizing Patients with Adverse Events After Immunization and Potential Contraindications to Immunization: A report from the Special Immunization Clinics Network. Pediatr Infect Dis J. 2016; 35: e384-391
    19. Chong J, Caya C, Levesque S, Quach C*. Heteroresistant Vancomycin Intermediate Coagulase Negative Staphylococcus in the NICU: A Systematic Review. PLoS One 2016; Oct. 7: 11(10): e0164136.
    20. Boikos C, Joseph L, Martineau C, Papenburg J, Scheifele D, Lands LC, De Serres G, Chilvers M, Quach C*. Influenza Virus Detection Following Administration of Live Attenuated Intranasal Influenza Vaccine in Children with Cystic Fibrosis and Their Healthy Siblings. Open Forum Infect Dis 2016; 3: ofw187
    21. DeLisle G, Quach C, Domingo MC, Boudreault AA, Gourdeau M, Bernatchez H, Lavallée C. E. coli Antimicrobial Susceptibility Profile and Cumulative Antibiogram to Guide Empirical Treatment of Uncomplicated Urinary Tract Infections in Women in the Province of Quebec, 2010-2015. J Antimicrob Chemother 2016; 71: 3562-3567.
    22. Kraicer-Melamed H, O’Donnell S, Quach C*. Corrigendum to : ‘The effectiveness of pneumococcal polysaccharide vaccine 23 (PPV23) in the general population of 50 years of age and older: A systematic review and meta-analysis” [Vaccine 34 (2016) 1540–1550]. Vaccine 2016; 34: 4083-4.
    23. Ducharme F, Zemek R, Chauhan B, Gravel J, Chalut D, Poonai N, Guertin MC, Quach C, Blondeau L, Laberge S; DOORWAY research group of PERC network. Factors associated with failure of emergency department management in children with acute, moderate or severe asthma: a prospective, multicentre, cohort study. Lancet Respiratory Medicine 2016; doi: 10.1016/S2213-2600 (16) 30160-6.
    24. Li L, Fortin E, Tremblay C, Ngenda-Muadi M, Quach C*; for SPIN-BACC. Central Line Association Bloodstream Infections in Québec Intensive Care Units: Results from the Provincial Healthcare-Associated Infections Surveillance Program (SPIN). Infect Control Hospit. Epidemiol. 2016; 37: 1186-94.
    25. Chong J, Quach C, Blanchard AC, Poliquin G, Golding G, Laferriere C, Lévesque S. Molecular epidemiology of vancomycin-intermediate heteroresistant coagulase negative Staphylococcus outbreak in the neonatal intensive care unit. Antimicrob Agents Chemother, 2016; 60: 5673-81.
    26. Fortin E, Platt RW, Fontela PS, Gonzales M, Buckeridge DL, Ovetchkine P, Quach C*. Measurement of Antimicrobial Resistance in the Respiratory Microbiota and Antimicrobial Use in Nine Intensive Care Units, Using Different Definitions and Indicators. JAMMI 2016; 2: 86-92.
    27. Al-Ghounaim M, Longtin Y, Gonzales M, Merckx J, Winters N, Quach C*. Clostridium difficile infections (CDI) in children: Impact of the Diagnostic Methods Used on Rates. Infect Control Hospit. Epidemiol. 2016; 37: 1087-93.
    28. Burstein B, Dubrovsky AS, Greene AW, Quach C. Emergency department and inpatient management of febrile infants under six weeks of age: National survey on the perceived utility of respiratory virus testing. Hosp. Pediatr 2016; 6: 226-233.
    29. Kraicer-Melamed H, O’Donnell S, Quach C*. The effectiveness of pneumococcal polysaccharide vaccine 23 (PPV23) in the general population of 50 years of age and older: A systematic review and meta-analysis. Vaccine 2016 Mar 18; 34(13):1540-50.
    30. Doll MK, Gagneur A, Tapiero B, Charest H, Gonzales M, Buckeridge DL, Quach C*. Temporal Changes in Pediatric Gastroenteritis Following Rotavirus Vaccination in Quebec. Pediatr Infect. Dis J 2016; 35 : 555-60.
      Media coverage »
    31. Comeau JL, Gagneur A, Quach C*. Impact of a Publicly Funded Monovalent Rotavirus Vaccination Program in the Province of Quebec (Canada). Vaccine 2016; 34(7): 893-8.
    32. Merckx J, McCormack D, Quach C*. Improving Influenza Vaccination in Chronically Ill Children using a Tertiary-Care Based Vaccination Clinic: Is there a Role for the Live-Attenuated Influenza Vaccine (LAIV)? Vaccine 2016; 34(6): 750-6.
    33. Fortin E, Quach C, Fontela PS, Buckeridge DL, Platt RW. A Simulation Study to Assess Indicators of Antimicrobial Use as Predictors of Resistance: Is it Possible to Identify the Most Accurate Indicator? PLoS One 2015 Dec 23; 10(12): e0145761. doi: 10.1371/journal.pone.0145761.
    34. Fortin E, Platt RW, Fontela PS, Buckeridge DL, Quach C*. Predicting Antimicrobial Resistance Prevalence and Incidence from Indicators of Antimicrobial Use: What Is the Most Accurate Indicator? PLoS One 2015 Dec 28; 10(12): e0145088. doi: 10.1371/journal.pone.0145088. eCollection 2015.
    35. Zavalkoff S, Korah N, Quach C. Presence of a Physician Safety Champion is Associated with a Reduction in Urinary Catheter Utilization in the Pediatric Intensive Care Unit. PLoS One 2015 Dec 14;10(12):e0144222. doi: 10.1371/journal.pone.0144222. eCollection 2015.
    36. Doll MK, Buckeridge DL, Morrison K, Gagneur A, Tapiero B, Charest H, Quach C*. Effectiveness of Monovalent Rotavirus Vaccine in a High-Income, Predominant Use Setting. Vaccine 2015; 33 (51): 7307-14.
    37. Le Saux N, Gravel D, Mulvey M, Moore D, Langley JM, Richardson S, Quach C, Baekyung Choi K, Miller M, Katz K and the Canadian Nosocomial Infection Surveillance Program. Healthcare Associated Clostridium difficile Infections and Strain Diversity in Pediatric Hospitals in the Canadian Nosocomial Infection Surveillance Program: 2007-2011. J Pediatr Infect Dis Society 2015; Dec;4(4): e151-e154.
    38. Gagneur A, Pinquier D, Quach C. Immunization of preterm infants. Human Vaccines & Immunotherapeutics 2015; 11 (11): 2556-63.
    39. Leduc S, Bush K, Campbell J, Cassidy K, Collet JC, Forrester L, Henderson E, Leal J, Leamon A, Pelude L, Mitchell R, Mukhi SH, Quach C, Shurgold J, Simmonds K and CNISP. What can an audit of national surveillance data tell us? Findings from an audit of Canadian vancomycin-resistant enterococci surveillance data. Can J Infect Control 2015; Summer 2015: 75-81.
    40. Lefebvre MA, Quach C, Daniel S. Chronic Suppurative Otitis Media due to Nontuberculous Mycobacteria: A Case of Successful Treatment with Topical Boric Acid. International J Pediatr Otorhinolaryngol 2015; 79: 1158-60.
    41. Caya C, Boikos C, Desai S, Quach C*. Dosing Regimen of the 23-Valent Pneumococcal Vaccination: A Systematic Review. Vaccine 2015; 33: 1302-12.
    42. Blanchard AC, Quach C, Autmizguine J. Staphylococcal infections in infants: Updates and current challenges. Clinics in Perinatology 2015; 42:119-32.
    43. Fortin E, Gonzales M, Fontela PS, Platt RW, Buckeridge D, Quach C*. Improving quality of data extractions for the computation of patient-days and admissions. American J Infect Control 2015; 43: 174-6.
    44. Li L, Fortin E, Tremblay C, Ngenda-Muadi M, Garenc C, Moisan D, Villeneuve J, Quach C*, for SPIN-BACC and SPIN-SARM. Hospital-Acquired Methicillin-Resistant Staphylococcus aureus Bloodstream Infections in Québec  Impact of Guidelines. Infect Contr Hospit Epidemiol 2017; 38 : 840-7.
    45. Dahan M, O’Donnell S, Hebert J, Gonzales M, Lee B, Chandran U, Woolsey S, Excoredo S, Chinnery H, Quach C*. CLABSI Risk Factors in the NICU: Potential for Prevention – A PICNIC Study. Infect Control Hosp Epidemiol 2016; 37: 1446-52
    46. Doll MK, Morrison KT, Buckeridge DL, Quach C*. Two Birds One Stone: Estimating Population Vaccination Coverage from a Test-Negative Vaccine Effectiveness Case-Control Study. Clin Infect Dis 2016; 63: 1080-6.
    47. Thrall S, Doll MK, Nhan C, Gonzales M, Perreault T, Lamer P, Quach C*. Evaluation of Rotavirus Vaccination in Neonatal Intensive Care Units. Vaccine 2015; 33 (39): 5095-5102. 
    48. Quach C*, Milstone AM, Perpete C, Bonenfant M, Moore DL, Perreault T. Chlorhexidine Bathing in a Tertiary-Care Neonatal Intensive Care Unit: Impact on Central Line Associated Bloodstream Infections. Infect Control Hospit Epidemiol 2014; 35: 158-63.
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